Effects of Hemorrhagic Shock on a Rat Unilateral Lung Contusion Model

Badami, Chirag D.; Watkins, Anthony C.; McCraken, B.; Caputo, Frank; Sifri, Ziad C.; Bonilla, Larissa; Mohr, Alicia M.; Deitch, E. A.; Livingston, David H.

doi:10.1097/00024382-200606001-00273

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2007

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“…12 Animals were allowed to recover from the LC until their heart rate and blood pressure stabilized, approximately 15 minutes, and then were randomly allocated to either HS or sham shock (SS) as previously described. 12 Hemorrhagic shocked rats underwent blood withdrawal until the mean arterial pressure was reduced to 40 mm Hg. This pressure was maintained at this level for 45 minutes by withdrawing or reinfusing shed blood (kept at 37°C) as needed.…”

Section: Lc and Hsmentioning

confidence: 99%

Hematopoietic Progenitor Cells Mobilize to the Site of Injury After Trauma and Hemorrhagic Shock in Rats

Badami

Livingston

Sifri

et al. 2007

Journal of Trauma: Injury, Infection &Amp; Critical Care

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Unilateral LC results in the rapid mobilization of a significant number of HPC from the BM to the site of injury. BM function is maintained under this condition. The addition of HS increases HPC mobilization from the BM and sequestration at the site of injury as well as decreasing BM HPC growth. We postulate that the accumulation of progenitor cells in the injured tissue combined with an alteration of normal BM homing, as exemplified by the decrease in progenitor cells from the lung without restoration of BM function, plays a role in posttraumatic BM suppression. The mechanism of shock-mediated mobilization from the BM and the exact role and fate of these cells at the site of injury requires further investigation.

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Section: Lc and Hsmentioning

confidence: 99%