Effects of Herbal Supplements on Drug Glucuronidation. Review of Clinical, Animal, and<i>In Vitro</i>Studies

Mohamed, Mohamed‐Eslam F.; Frye, Reginald F.

doi:10.1055/s-0030-1250457

Cited by 86 publications

(66 citation statements)

References 91 publications

(129 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E-3-G was quantified by HPLC. IC 50 was 0.562 mg/mL, which would be reached by dissolving one daily dose in a volume of 1.8 L. According to the authors, this volume is in the same order of magnitude as the volume of the intestine, and therefore a potential effect in the intestine could not be excluded [48]. However, even if a transient partial inhibition of UGT 1A1 in the intestine would occur, it would be transient, rather than a long-lasting enzyme induction, and could not to lead to a persistent change of bioavailability of another drug.…”

Section: In Vitro Studiesmentioning

confidence: 99%

Valerian: No evidence for Clinically Relevant interactions

Kelber¹,

Nieber²,

Kraft³

2012

Planta Med

View full text Add to dashboard Cite

In recent popular publications as well as in widely used information websites directed to cancer patients, valerian is claimed to have a potential of adverse interactions with anticancer drugs. This questions its use as a safe replacement for, for example, benzodiazepines. A review on the interaction potential of preparations from valerian root (Valeriana officinalis L. root) was therefore conducted. A data base search and search in a clinical drug interaction data base were conducted. Thereafter, a systematic assessment of publications was performed. Seven in vitro studies on six CYP 450 isoenzymes, on p-glycoprotein, and on two UGT isoenzymes were identified. However, the methodological assessment of these studies did not support their suitability for the prediction of clinically relevant interactions. In addition, clinical studies on various valerian preparations did not reveal any relevant interaction potential concerning CYP 1A2, 2D6, 2E1, and 3A4. Available animal and human pharmacodynamic studies did not verify any interaction potential. The interaction potential of valerian preparations therefore seems to be low and thereby without clinical relevance. We conclude that there is no specific evidence questioning their safety, also in cancer patients.

show abstract

Section: In Vitro Studiesmentioning

confidence: 99%

Valerian: No evidence for Clinically Relevant interactions

Kelber¹,

Nieber²,

Kraft³

2012

Planta Med

View full text Add to dashboard Cite

show abstract

“…These compounds including iridoids, flavonoids, lignans, coumarins and anthraquinones 7,8 . The purposes of this study were to evaluate antioxidant, antitumoral and antimicrobial activity of ethanolic extract from Morinda citrifolia L. fruit grown in Southeast Brazil.…”

Section: Products Derived Frommentioning

confidence: 99%

Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

et al. 2014

View full text Add to dashboard Cite

“…The interaction between herbal drug and conventional drug would be observed for safety concern and these interactions are especially important for drugs that have narrow therapeutic index. 1,4,5 The conventional drug typically contains single chemical moiety, whereas most of herbal drugs (even single the herb drug) contains more than one chemical moiety having pharmacological activity. Therefore, the probability of herb-drug interaction can be higher than drug-drug interaction.…”

Section: Introductionmentioning

confidence: 99%

Possible interactions between garlic and conventional drugs: a review

Kansara

Jani

2017

PBE

View full text Add to dashboard Cite

Herbs can affect body function; therefore, when herbs are taken concurrently with drugs, interactions are possible. The interaction between drugs and herbal medicines is a safe concern and these interactions are especially important for drugs with narrow therapeutics index. The probability of herb-drug interaction can be higher than drug interaction, if conventional drug having single chemical entities, whereas most of the herbal medicinal product contain a mixture of pharmacologically active constituents. The herb-drug interaction may involve either an increase or decrease in the amount of drug in blood, either by altering the absorption, distribution, metabolism, and elimination (ADME) of drug and by antagonizing or synergism of the effect of drug or pharmacodynamics interaction may arise. This article we focus on how garlic interacts with conventional drug or it is favourable or not.

show abstract

Effects of Herbal Supplements on Drug Glucuronidation. Review of Clinical, Animal, andIn VitroStudies

Cited by 86 publications

References 91 publications

Valerian: No evidence for Clinically Relevant interactions

Valerian: No evidence for Clinically Relevant interactions

Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

Possible interactions between garlic and conventional drugs: a review

Contact Info

Product

Resources

About