Effects of High Ascorbic Acid Intake on the Metabolism of Catecholamines in the Rat

Abstract

The effect of high dietary ascorbic acid intake on the homeostasis of ascorbic acid and on the metabolism of catecholamine was studied in rats. In order to eliminate changes in serum levels due to stress, blood was obtained without anesthesia through implanted cannulas. Rats with a high intake of ascorbic acid (20 g/kg diet, for 7-9 weeks) had significantly higher levels of ascorbic acid in serum (83%), liver (28%), kidney (47%) and superior cervical ganglia (43%). The values were slightly, but not significantly higher in adrenal gland, brain and interscapular brown adipose tissue. However, no significant differences were observed in the levels of noradrenalin, adrenalin and dopamine in any of the tissues analyzed. Dopamine beta-hydroxylase activity was also unchanged. There was thus no evidence of an effect of high dietary intakes of ascorbic acid on the metabolism of catecholamines in the intact rat.

Uso de vitamina C en la solución tumescente de liposucción como inductor de lipolisis y fibrosis: Trabajo experimental

“…A nivel tisular la función de la vitamina C está relacionada con la síntesis de colágeno, proteoglicanos y otros constituyentes orgánicos de la matriz intercelular. La vitamina C disminuye el efecto de glicosilación insulínica (17) e interviene en las reacciones de oxidoreducción tisular disminuyendo la peroxidación lipídica, lo cual se evidencia en una disminución de la formación de placas de ateromas (6,(18)(19)(20)(21). Uno de los efectos más importantes de la vitamina C es la activación de la lipoprotein-lipasa, la cual es una enzima relacionada con ruptura y absorción de los triglicéridos en la sangre y el aumento de la tasa basal de lipolisis adrenérgica en el tejido adiposo (6).…”