Effects of High but Non-Toxic Dietary Intake of Selenium and Copper on Indices of the Antioxidant Defence System and on Accumulation of Trace Elements in Chicks

Apsite, M. R.; Bērziņa, Nadežda; N., Basova,

doi:10.2478/v10046-012-0006-z

Cited by 5 publications

(5 citation statements)

References 22 publications

(23 reference statements)

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“…Elevation in the concentration of uric acid in the blood might be confirmed lipid peroxidation caused by Cu toxicity, causing a disturbance in kidney excretion function [12,70]. Another study stated significantly higher uric acid concentrations in the serum of broilers given high dietary copper levels [71]. These findings were confirmed by the histopathological findings in the kidney, which showed extensive necrosis of the renal tubular epithelial, hypercellularity and lymphocytic infiltrations of glomeruli, extensive hemorrhages, hemolysis, and hyaline cast inside some tubular lumina.…”

Section: Discussionmentioning

confidence: 99%

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Hashem

Hamied

Ahmed

et al. 2021

Animals

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The current investigation evaluated the alleviating effects of vitamin C and vitamin E on oxidative stress, hematobiochemical, and histopathological changes in the kidney induced by copper sulfate (CuSO4) toxicity in chickens. Two hundred and fifty-one-day-old male broiler chicks were randomly allotted into five experimental groups (five replicates/group, ten chicks/replicate): 1st group—basal diet with no additives (control group), 2nd group—basal diet complemented with CuSO4 (300 mg/kg diet), 3rd group—basal diet with CuSO4 (300 mg/kg diet) + vitamin C (250 mg/kg diet), 4th group—basal diet with CuSO4 (300 mg/kg diet) + vitamin E (250 mg/kg diet), and 5th group—basal diet with CuSO4 (300 mg/kg diet) + vitamin C (250 mg/kg diet) + vitamin E (250 mg/kg diet) for a 42 day feeding period. The results showed a significant reduction in red blood cells (RBCs), hemoglobin (Hb) concentration, and hematocrit values as well as total leukocyte counts (WBCs), lymphocyte, heterophil, and monocyte counts in the CuSO4-intoxicated birds (2.42 × 106/µL, 9.54 g/dL, 26.02%, 15.80 × 103/µL, 7.86 × 103/µL, 5.26 × 103/µL, and 1.18 × 103/µL, respectively, at the 6th week) compared to (2.79 × 106/µL, 10.98 g/dL, 28.46%, 21.07 × 103/µL, 10.84 × 103/µL, 7.12 × 103/µL, and 1.60 × 103/µL, respectively) in the control group. Moreover, CuSO4-intoxicated birds showed hypoglycemia with a rise in serum uric acid and creatinine levels (122.68, 5.18, and 0.78 mg/dL at the 6th week) compared to (159.46, 4.41, and 0.61 mg/dL) in the control group. The CuSO4 toxicity in birds induced oxidative stress, indicated by a high serum malondialdehyde level (MDA) and diminished activity of the antioxidant enzymes (glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)) (2.01 nmol/mL, 37.66 U/mL, and 2.91 U/mL, respectively, at the 6th week) compared to (1.34 nmol/mL, 57.00 U/mL, 4.99 U/mL, respectively) in the control group. High doses of Cu exposure caused severe microscopic alterations in kidney architecture. The addition of vitamins C and E, singularly or in combination, displayed a beneficial effect in alleviating these harmful effects of Cu toxicity. These findings showed the possible mitigating impacts of dietary antioxidants on the hematobiochemical alterations, oxidative stress, and kidney damage induced by CuSO4 toxicity.

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Section: Discussionmentioning

confidence: 99%

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Hashem

Hamied

Ahmed

et al. 2021

Animals

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“…Both Cu and Cr are metals required by the body. It is known that 5-10 mg/kg of Cu are required in the diet of poultry with the maximum concentration that can be tolerated being 250 mg/kg; however, physiology is not the same in different species of birds, and thus, specific studies need to be performed to determine the threshold for intoxication [3]. In case of Cr, it is difficult to evaluate the concentration required to determine intoxication, because the homeostasis mechanism acts as a defense, preventing high concentrations from being absorbed [27].…”

Section: Discussionmentioning

confidence: 99%

“…The weights were adjusted between 0.1 and 0.2 g. The samples were then placed in tubes containing 4 mL of HNO 3 (65%) and 4 mL of H 2 O 2 (30%) followed by being placed in a Mars ® Microwave Digester 2 [7]. For quantification of Pb, Cd, Cr, and Cu (µg/g) the digested samples were diluted using deionized water (1:10) and analyzed using an inductively coupled plasma optical emission spectrometer (ICP-OES, Optima 7000 DV ® ) 3 with axial configuration. For quantification of Hg, the samples were analyzed using an atomic absorption spectrophotometer (Varian AA240FS ® ) 4 , with Hydride Generator Systems (model VGA 77) 5 .…”

Section: Heavy Metal Analysis In Feathers and Liversmentioning

confidence: 99%

Heavy Metal Concentrations in Free-Living Southern Caracaras (Caracara plancus) in the Northeast Region of Brazil

Silva

Filho

Kunst

et al. 2017

Acta Scientiae. Vet.

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Background: With the continuously increasing release of heavy metals in the environment, mostly from anthropogenic sources, there is a need to find ways of evaluating and managing the issuance of these contaminants and correct its damages. The birds being at the top of some food chains reflect the presence of metals in the environment, keeping this in perspective, raptors have been successfully used for heavy metals biomonitoring studies in the past. The purpose of this study was to identify and quantify cadmium (Cd), mercury (Hg), lead (Pb), copper (Cu), and chromium (Cr) in the feathers and livers of free-living southern caracaras, live and dead, from Recife, Pernambuco state, Northeast of Brazil. Material, Methods & Results: Sixty-two feathers from live and dead southern caracaras and 21 livers from dead southern caracaras were analyzed by atomic absorption spectrometry for Hg and by inductively coupled plasma optical emission spectrometry for Cd, Cr, Pb, and Cu. Concentrations of Cr and Cu elements were detected in all feather and liver samples analyzed from live and dead caracaras. There was no difference in the concentration of metals between feathers of dead and live caracaras: Pb (P = 0.3576), Cd (P = 0.0792), Cr (P = 0.5475), and Cu (P = 0.3603), but significant variation was observed for Hg (P = 0.0459). The highest concentrations of Pb (P < 0.0001) and Cr (P < 0.0001) were found in the feathers than in the liver. On the other hand, the highest concentrations of Cu were found in liver samples (P = 0.0011). No significant variation in the concentrations of Cd (P = 0.7770) and Hg (P = 0.3669) was found between feathers and liver samples. Discussion: Chromium, as well as Hg, and Cu have a high affinity for keratin, which may explain the higher concentrations of Cr in caracaras feathers in this research. Lead was detected in all liver samples analyzed. Elevated levels were also found in the feathers of dead (95.2%) and live (75.6%) caracaras. The presence of Pb may be due to external contamination by pollutants, such as fossil fuels. Higher concentrations of Hg were observed in dead caracaras feathers, this concentrations change during molting but are not affected by external contamination. Metals, such as Hg, and Cd, accumulate in organisms from different trophic levels, which may indicate that this contamination comes mainly from feed. Pearson's coefficient here showed no correlation between metals from dead caracaras feathers and livers, although a few previous studies have shown a correlation between metal concentrations from tissues and feathers. This pattern can be attributed to the different time of exposure of feathers to metals in relation to livers. The concentrations of metals in hepatic tissues reflect the levels of elements in the diet of these birds, characterizing acutely the contamination of the ecosystem. On the other hand, feathers represent the exposure in the time of molting, when the artery supplies metals, thus representing a chronic exposure. In feathers from live birds, the ...

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“…Later the initial material in most cases was developed by the method of intervarietal hybridization. Oat cultivars 'Stipruolės', 'Dotnuvos baltosios', 'Gyrūnės', 'Skaistūnės', 'Sidabrės', 'Šušvė', 'Jaugila', 'Migla DS' and hulless 'Mina DS' have been developed during a 90 years' period (Kulikauskas, Sprainaitienė, 1998;Danytė, 2012).…”

Section: Introductionmentioning

confidence: 99%

Trends changes of oat genotypes grown in Lithuania

Danytė

Gorash

Liatukienė

et al. 2020

Zemdirbyste-Agriculture

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A study was carried out at Institute of Agriculture, Lithuanian Research Centre for Agriculture and Forestry. A total of 37 oat (Avena sativa L.) genotypes, which had been registered, grown or selected in Lithuania over the period 1934-2013 were analysed. Precision field trials were conducted. Conventional technology for oat cultivation was employed. The relationship between oat genotypes and year of registration, growth and selection was calculated. The greatest progress of oat genotypes registered, grown or selected in Lithuania was in the increase of yield (R = 0.73), hectolitre weight (R = 0.53), and plant height decrease (R = −0.57); the highest decrease was found in protein content (R = −0.55). The new cultivars tended to show a higher thousand grain weight, better resistance to lodging, higher starch and lower fat content, lower resistance to crown rust.

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Effects of High but Non-Toxic Dietary Intake of Selenium and Copper on Indices of the Antioxidant Defence System and on Accumulation of Trace Elements in Chicks

Cited by 5 publications

References 22 publications

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Heavy Metal Concentrations in Free-Living Southern Caracaras (Caracara plancus) in the Northeast Region of Brazil

Trends changes of oat genotypes grown in Lithuania

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