1991
DOI: 10.1016/0002-9149(91)90274-o
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Effects of high-density lipoprotein on acetylcholine-induced coronary vasoreactivity

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Cited by 158 publications
(63 citation statements)
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“…Possible explanations include the fact that HDL-C has antioxidant and antiinflammatory properties (6, 7), attenuates endothelial dysfunction (8,9), has anticoagulant effects (10,11), and enhances the half-life of prostacyclin (12)(13)(14). The antiinflammatory properties of HDL-C may be particularly relevant here, because we observed systemic inflammation and endothelial activation in patients with PAH with low HDL-C levels (Table 8).…”
Section: Discussionmentioning
confidence: 85%
See 1 more Smart Citation
“…Possible explanations include the fact that HDL-C has antioxidant and antiinflammatory properties (6, 7), attenuates endothelial dysfunction (8,9), has anticoagulant effects (10,11), and enhances the half-life of prostacyclin (12)(13)(14). The antiinflammatory properties of HDL-C may be particularly relevant here, because we observed systemic inflammation and endothelial activation in patients with PAH with low HDL-C levels (Table 8).…”
Section: Discussionmentioning
confidence: 85%
“…High-density lipoprotein cholesterol (HDL-C) is associated with a lower risk of coronary heart disease (4,5).The underlying mechanisms behind this protective effect include stimulation of reverse cholesterol transport, antioxidant and antiinflammatory properties (6,7), attenuation of endothelial dysfunction (8,9), anticoagulant effects (10,11), and enhancement of prostacyclin half-life (12)(13)(14). Interestingly, except for reverse cholesterol transport, derangements in all of these mechanisms have been implicated in the pathobiology of PAH.…”
mentioning
confidence: 99%
“…This study was among the first in humans to demonstrate the important role of endothelial dysfunction early in the course of atherosclerosis. Similarly, abnormal vasomotion occurs in subjects with uncomplicated hypertension (71), diabetes (72)(73)(74)(75), cigarette smoking (76,77) and low levels of high density lipoprotein (78,79). Oxidized low density lipoprotein plays an important role in abnormal endothelial vasorelaxation, leukocyte adhesion and endothelin production (80)(81)(82)(83).…”
Section: Relationship Of Endothelial Function To Risk Factors and Thementioning
confidence: 99%
“…These observations provide an explanation for the previously reported association of high plasma HDL levels with normal endothelium-dependent arterial relaxation in humans. 22,39 …”
Section: Deckert Et Almentioning
confidence: 99%
“…Indeed, a direct relationship between plasma HDL cholesterol levels and the vasodilation of coronary artery in response to ACh was reported among patients with or without evidence for coronary atherosclerosis. 22 Complementary ex vivo studies on arterial rings further supported the role of HDL and apoA-I in reversing the oxidized LDL-induced impairment of endothelium-dependent arterial relaxation. 23,24 Whereas apoE-deficient mice (apoE-KO mice) recently arose as one of the most relevant animal models for studying human atherosclerosis, 25,26 the role of lipoproteins in regulating the vascular tone in apoE-KO mice has not been clearly established.…”
mentioning
confidence: 91%