Effects of high dietary iron on the lipid metabolism in the liver and adipose tissue of male broiler chickens

Bai, Shiping; Luo, Wei; Liu, Huan; Zhang, Keying; Wang, Jianping; Ding, Xuemei; Zeng, Qiufeng; Peng, Huanwei; Bai, Jie; Xuan, Yue; Su, Zuowei

doi:10.1016/j.anifeedsci.2021.115131

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…In addition, there were no differences in ADFI and FCR during the growth phase, nor during the entire experimental period, which may be due to reduced Fe absorption with advancing age [34]. The current result was consistent with previous findings, which reported that high dietary Fe administration of 690 mg Fe/kg in the form of ferrous sulfate decreases the growth performance of broilers during days 1-21 [14]. However, the EFSA [18] reported that BW, feed intake, and FCR in Ross 308 chickens were not affected by diets containing 290 or 590 mg Fe/kg in the form of Fe-LG, whereas the BW and feed intake are increased by supplementation with 590 mg Fe/kg in the form of ferrous sulfate.…”

Section: Discussionsupporting

confidence: 92%

“…In the current study, the liver indices on day 42 decreased in broilers fed diets supplemented with 400 and 800 mg Fe/kg. Furthermore, supplementation with 800 mg Fe/kg significantly decreased the heart, spleen, and kidney indices, which may be induced by the Fe deposition in bodies or the changes in lipid metabolism owing to high dietary Fe supplementation in broilers [14].…”

Section: Discussionmentioning

confidence: 97%

“…The organ index is an important parameter reflecting the status of organ development in animals [35]. Bai et al [14] reported that high dietary Fe supplementation (500 mg Fe/kg) in the form of Fe sulfate heptahydrate does not affect liver weight and liver yield during days 1-21 in Ross 308. In the current study, the liver indices on day 42 decreased in broilers fed diets supplemented with 400 and 800 mg Fe/kg.…”

Section: Discussionmentioning

confidence: 99%

“…Fe overload can induce oxidative stress [11], impair immunity by releasing inflammatory cytokines, accelerate hepatocyte apoptosis, and cause serious structural and functional damages to the liver, heart, or intestines [12,13]. The administration of high dietary Fe content (500 mg Fe/kg DM) in the form of Fe sulfate heptahydrate reduces abdominal adipose fat deposition and liver triglyceride accumulation in male Ross 308 broilers [14]. In addition, Fe overload may lead to the pathogenesis of atherosclerosis, since excess Fe is closely related to reactive oxygen species (ROS) generation, lipoprotein oxidation, and platelet activation in mice [15,16].…”

Section: Introductionmentioning

confidence: 99%

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High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

Han

Xin

et al. 2022

Animals

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Although Iron (Fe) is an essential nutrient that plays a vital role in respiratory processes, excessive Fe in the diet can affect the health of broilers. We investigated the effects of diet supplemented with high levels of iron chelates with lysine and glutamic acid (Fe–LG) on the growth performance, serum biochemical parameters, antioxidant status, and duodenal mRNA expression of Fe transporters in broilers. A total of 800 1-day-old male Arbor Acres broilers were assigned to 5 groups, with 8 replicates each. Broilers were fed a corn–soybean meal basal diet or basal diets supplemented with 40, 80, 400, or 800 mg Fe/kg as Fe–LG for 6 weeks. The body weight (BW) was increased in the 80 mg Fe/kg treatment group, but decreased in the 800 mg Fe/kg treatment group on day 21. During days 1–21, compared with the control group, the supplementation of the 80 mg Fe/kg increased the average daily gain (ADG) and average daily feed intake (ADFI); however, the supplementation of the 800 mg Fe/kg group decreased the ADG and increased the FCR in broilers (p < 0.05). The heart, liver, spleen, and kidney indices were reduced in the 800 mg Fe/kg treatment group (p < 0.05). The supplementation of the 800 mg Fe/kg group increased the serum aspartate aminotransferase activity and the levels of creatinine and urea nitrogen on day 42 (p < 0.05). The broilers had considerably low liver total superoxide dismutase activity and total antioxidant capacity in the 800 mg Fe/kg treatment group (p < 0.05). Serum and liver Fe concentrations were elevated in the 400 and 800 mg Fe/kg treatment groups, but were not affected in the 40 and 80 mg Fe/kg treatment groups. The duodenal Fe transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) were downregulated in the Fe–LG treatment groups (p < 0.05). We conclude that a high dietary supplement of 800 mg Fe/kg in broilers leads to detrimental health effects, causing kidney function injury and liver oxidative stress.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

Han

Xin

et al. 2022

Animals

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“…In broilers, the liver is the main organ for de novo fatty acid synthesis, and the abdominal adipose serves as the main lipid storage site. Thus, abdominal adipose deposition depends on hepatic fatty acid synthesis and the utilization of serum TG by adipocytes [39,40]. To elucidate the molecular mechanism of lipid metabolism and abdominal adipose deposition, we further evaluated hepatic lipogenesis-and lipolysis-related gene expression.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in Hepatic Lipid Metabolism and Abdominal Adipose Deposition in Yellow-Feathered Broilers Aged from 1 to 56 Days

Lan,

Wei,

et al. 2023

Animals

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The objective of this study was to evaluate the age-related changes in hepatic lipid metabolism, adipocyte hyperplasia, hypertrophy, and lipid metabolism in the abdominal adipose tissue of yellow-feathered broilers. Blood, liver, and abdominal adipose samples were collected on days 1, 7, 14, 21, 28, 35, 42, 49, and 56. Body, liver, and abdominal weight increased (p < 0.05) with age-related changes. The triacylglycerol content peaked on day 14, and total cholesterol content peaked on day 56. The adipocyte diameter and area peaked on day 56, and total DNA content peaked on day 7. The age-related changes in hepatic lipogenesis-related gene (ChREBP, SREBP-1c, ACC, FAS, SCD1) expression mainly occurred during days 1 to 21, hepatic lipolysis-related gene (CPT1, LPL, ApoB) expression mainly occurred during days 1 to 14, and abdominal adipose-deposition-related gene (PPARα, CPT1, LPL, PPARγ, C/EBPβ) expression occurred during days 1 to 14. These results demonstrated a dynamic pattern of hepatic lipid metabolism and abdominal adipose deposition in yellow-feathered broilers, which provides practical strategies to regulate hepatic lipid metabolism and reduce abdominal adipose deposition in yellow-feathered broilers.

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Effects of dietary iron concentrations on growth performance, ascites incidence, blood biochemical parameters, and antioxidant status of broiler chickens in ascites inducing condition

Akbari,

Shahir,

Tzschentke

et al. 2025

Animal Feed Science and Technology

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Effects of high dietary iron on the lipid metabolism in the liver and adipose tissue of male broiler chickens

Cited by 10 publications

References 39 publications

High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

Age-Related Changes in Hepatic Lipid Metabolism and Abdominal Adipose Deposition in Yellow-Feathered Broilers Aged from 1 to 56 Days

Effects of dietary iron concentrations on growth performance, ascites incidence, blood biochemical parameters, and antioxidant status of broiler chickens in ascites inducing condition

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