Effects of high fat diet-induced obesity and pregnancy on prepartum and postpartum maternal mouse behavior

Moazzam, Showall; Jarmasz, Jessica S.; Jin, Yan; Siddiqui, Tabrez J.; Cattini, Peter A.

doi:10.1016/j.psyneuen.2021.105147

Cited by 17 publications

(62 citation statements)

References 54 publications

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“…When the test was repeated on P7, when maternal behaviors are consolidated, there were no differences between groups. While these subtle differences are consistent with other published findings in mice that maternal obesity can reduce the quality of maternal care (Bellisario et al, 2015;Bolton et al, 2017;Moazzam et al, 2021), another study in rats showed that HFD increased the time that the dams nursed their pups (Purcell et al, 2011). Because the methods and endpoints used to assess maternal care are not consistent across these or our experiments, it is difficult to determine what are true effects of maternal diet or obesity on maternal care, and what is simply the reflection of natural variations in maternal care that occur over and within the early postpartum days.…”

Section: Effects Of Diet and Selective Breeding On Behavioral Profile...supporting

confidence: 92%

“…A handful of studies have investigated how consumption of a high fat diet (HFD) during pregnancy and postpartum can influence maternal behavioral and physiological parameters in mice and rats. When reported, these studies unequivocally show that consuming HFD during pregnancy leads to increased gestational weight gain (Wahlig et al, 2012;Bolton et al, 2017;Qiao et al, 2019;Moazzam et al, 2021). While several demonstrated that HFD influenced metabolic and behavioral adaptations in the early postpartum period, these findings are not always consistent with one another (Purcell et al, 2011;Bellisario et al, 2015;Bolton et al, 2017;Moazzam et al, 2021), and very few have investigated the influence of diet over the full length of the postpartum period or in the post-weaning phase (Qiao et al, 2019).…”

Section: Introductionmentioning

confidence: 97%

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Influence of High Energy Diet and Polygenic Predisposition for Obesity on Postpartum Health in Rat Dams

et al. 2022

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It is estimated that 30% of pregnant women worldwide are overweight or obese, leading to adverse health effects for both mother and child. Women with obesity during pregnancy are at higher risk for developing both metabolic and mental disorders, such as diabetes and depression. Numerous studies have used rodent models of maternal obesity to understand its consequences on the offspring, yet characterization of changes in the dams is rare, and most rodent models rely solely on a high fat diet to induce maternal obesity, without regarding genetic propensity for obesity. Here we present the influence of both peripartum high energy diet (HE) and obesity-proneness on maternal health using selectively bred diet-resistant (DR) and diet-induced obese (DIO) rat dams. Outbred Sprague-Dawley rats were challenged with HE diet prior to mating and bred according to their propensity to gain weight. The original outbred breeding dams (F0) were maintained on low-fat chow during pregnancy and lactation. By comparison, the F1 dams consuming HE diet during pregnancy and lactation displayed higher gestational body weight gain (P < 0.01), and HE diet caused increased meal size and reduced meal frequency (P < 0.001). Sensitivity to the hormone amylin was preserved during pregnancy, regardless of diet. After several rounds of selective breeding, DIO and DR dams from generation F3 were provided chow or HE during pregnancy and lactation and assessed for their postpartum physiology and behaviors. We observed strong diet and phenotype effects on gestational weight gain, with DIO-HE dams gaining 119% more weight than DR-chow (P < 0.001). A high-resolution analysis of maternal behaviors did not detect main effects of diet or phenotype, but a subset of DIO dams showed delayed nursing behavior (P < 0.05). In generation F6/F7 dams, effects on gestational weight gain persisted (P < 0.01), and we observed a main effect of phenotype during a sucrose preference test (P < 0.05), with DIO-chow dams showing lower sucrose preference than DR controls (P < 0.05). Both DIO and DR dams consuming HE diet had hepatic steatosis (P < 0.001) and exhibited reduced leptin sensitivity in the arcuate nucleus (P < 0.001). These data demonstrate that both diet and genetic obesity-proneness have consequences on maternal health.

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Section: Effects Of Diet and Selective Breeding On Behavioral Profile...supporting

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Influence of High Energy Diet and Polygenic Predisposition for Obesity on Postpartum Health in Rat Dams

et al. 2022

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“…In generations F6/F7, we observed a main effect of both phenotype and diet, with DR-chow animals showing higher sucrose preference compared to DIO-chow dams. These data are similar to those reported by Moazzam and colleagues, where pregnant mice on chow displayed higher sucrose preference compared to pregnant mice on HFD [15]. Resistance of the DIO rat dams to consume sweet solution was also observed during the OGTTs performed in the F6 generation, by which we had to abandon the more clinicallyand physiologically-relevant drinking of glucose during the OGTT for gavage administration.…”

Section: Effects Of Diet and Selective Breeding On Behavioral Profile Of Postpartum Damssupporting

confidence: 89%

“…In contrast, HE dams stayed nearly stable with their body weight after parturition until P25. This effect of HE on the pattern of postpartum body weight changes was observed over several generations, and a similar trend can be observed in recently published work in mouse dams [15]. While the significance of this pattern will require additional probing, the consistency of the effect suggests that intake of HE can influence the metabolic adaptions that occur from pregnancy to postpartum.…”

Section: Effects Of Diet and Selective Breeding On Gestational Body Weight And Leptin Levelssupporting

confidence: 84%

“…Moazzam and colleagues reported that postpartum mouse dams maintained on HFD spent less time in the closed arms of an EPM than chow-fed dams, which would actually indicate reduced anxiety [15]. Another study by Perani and colleagues showed that HFD prevented lactation-associated anxiolysis, with HFD-fed mouse dams showing an increase in the latency to enter the lit chamber of the light-dark box, and a decrease in the number of lit chamber entries [74].…”

Section: Effects Of Diet and Selective Breeding On Behavioral Profile Of Postpartum Damsmentioning

confidence: 99%

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Influence of high energy diet and polygenic predisposition for obesity on postpartum health in rat dams

Leuthardt

Bayer

Rodríguez

et al. 2021

Preprint

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It is estimated that 30% of pregnant women worldwide are overweight or obese, which leads to adverse health effects for both the mother and child. Women with obesity during pregnancy are at higher risk for developing both metabolic and mental disorders, such as diabetes and depression. Numerous studies have used rodent models of maternal obesity to understand its consequences on the offspring, yet characterization of changes in the dams is rare, and most rodent models rely solely on a high fat diet to induce maternal obesity, without regarding genetic propensity for obesity. Here we present the influence of both peripartum high energy diet (HE) and obesity-proneness on maternal health using selectively-bred diet-resistant (DR) and diet-induced obese (DIO) rat dams. Outbred Sprague-Dawley rats were selected and bred according to their propensity to gain weight. From F1 onward, dams consuming a HE diet displayed higher body weight gain during pregnancy, and HE diet had a strong effect on meal patterns. Sensitivity to the hormone amylin was preserved during pregnancy, regardless of diet. After several rounds of selective breeding, dams from generation F3 were assessed for their postpartum physiology and behaviors. We observed strong diet and phenotype effects on gestational weight gain, with DIO-HE dams gaining 119% more weight than DR-chow. A high-resolution analysis of maternal behaviors on postpartum day 2 (P2) did not detect main effects of diet or phenotype, but a subset of DIO dams showed decreased pup-related behaviors. During a sucrose preference test (SPT) on P14, all DR dams consumed at least 70% sucrose, while a subset of DIO dams preferred water. In generation F6/F7 dams, effects on gestational weight gain persisted, and we observed a main effect of phenotype on SPT, with DIO-chow dams showing the lowest sucrose preference. Both DIO and DR dams consuming HE diet had severe postpartum liver lipidosis and exhibited reduced leptin sensitivity in the arcuate nucleus at the time of pup-weaning. These data demonstrate that both diet and genetic obesity-proneness have consequences on maternal health.

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Differential effects of high-fat diet on endocrine, metabolic and depressive-like behaviors in male and female rats

Woodruff,

Bykalo,

Loyo-Rosado

et al. 2024

Appetite

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Effects of high fat diet-induced obesity and pregnancy on prepartum and postpartum maternal mouse behavior

Cited by 17 publications

References 54 publications

Influence of High Energy Diet and Polygenic Predisposition for Obesity on Postpartum Health in Rat Dams

Influence of High Energy Diet and Polygenic Predisposition for Obesity on Postpartum Health in Rat Dams

Influence of high energy diet and polygenic predisposition for obesity on postpartum health in rat dams

Differential effects of high-fat diet on endocrine, metabolic and depressive-like behaviors in male and female rats

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