Effects of high fat diets and supplemental tart cherry and fish oil on obesity and type 2 diabetes in male and female C57BL/6J and TALLYHO/Jng mice

Parkman, Jacaline; Sklioutovskaya-Lopez, Kristiana; Menikdiwela, Kalhara R.; Freeman, Logan; Moustaid‐Moussa, Naima; Kim, Jung Han

doi:10.1016/j.jnutbio.2021.108644

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…It may also cause a euglycemic balance in ROS production that maintains insulin sensitivity because ROS are also essential for insulin sensitization. There is growing evidence from previous studies on selenium tetrachloride's potential benefits that should be balanced with its potential harmful effects [42].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Efficacy of Vanadyl Sulfate and Selenium Tetrachloride as Anti-Diabetic Agents against Hyperglycemia and Oxidative Stress Induced by Diabetes Mellitus in Male Rats

Al-Salmi

Hamza

2021

CIMB

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The use of metals in medicine has grown in popularity in clinical and commercial settings. In this study, the immune-protecting effects and the hypoglycemic and antioxidant activity of vanadyl sulfate (VOSO4) and/or selenium tetrachloride (Se) on oxidative injury, DNA damage, insulin resistance, and hyperglycemia were assessed. Fifty male albino rats were divided into five groups, and all treatments were administrated at 9:00 a.m. daily for 60 successive days: control, STZ (Streptozotocin; 50 mg/kg of STZ was given to 6 h fasted animals in a single dose, followed by confirmation of diabetic state occurrence after 72 h by blood glucose estimation at >280 mg/dl), STZ (Diabetic) plus administration of VOSO4 (15 mg/kg) for 60 days, STZ (Diabetic) plus administration of selenium tetrachloride (0.87 mg/Kg), and STZ plus VOSO4 and, after 1/2 h, administration of selenium tetrachloride at the above doses. The test subjects’ blood glucose, insulin hormone, HbA1C, C-peptide, antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, myeloperoxidase, and xanthine oxidase), markers of lipid peroxidation (MDA), and histological sections of pancreatic tissues were evaluated, and a comet assay was performed. Histological sections in pancreas tissues were treated as indicators of both VOSO4 and selenium tetrachloride efficacy, either alone or combined, for the alleviation of STZ toxicity. The genotoxicity of diabetes mellitus was assessed, and the possible therapeutic roles of VOSO4 or selenium tetrachloride, or both, on antioxidant enzymes were studied. The findings show that the administration of VOSO4 with selenium tetrachloride reduced oxidative stress to normal levels, lowered blood glucose levels, and elevated insulin hormone. Additionally, VOSO4 with selenium tetrachloride had a synergistic effect and significantly decreased pancreatic genotoxicity. The data clearly show that both VOSO4 and selenium tetrachloride inhibit pancreatic and DNA injury and improve the oxidative state in male rats, suggesting that the use of VOSO4 with selenium tetrachloride is a promising synergistic potential ameliorative agent in the diabetic animal model.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Efficacy of Vanadyl Sulfate and Selenium Tetrachloride as Anti-Diabetic Agents against Hyperglycemia and Oxidative Stress Induced by Diabetes Mellitus in Male Rats

Al-Salmi

Hamza

2021

CIMB

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“…Among the 23 studies that assessed IL‐6, the effect of DIO was reported in 17 studies in males and 18 studies in females. Following DIO intervention, IL‐6 was higher in males compared with females by approximately 2.6‐fold according to seven (4%) studies, 23,30,34,45–48 whereas no sex differences were reported in 15 (65%) studies 31,33,35–42,49–53 . In females, IL‐6 increased by 1.4‐ to 5.2‐fold after DIO according to nine (50%) studies, 33,37,38,40,45,48–50,52 whereas another nine studies observed a neutral effect 34–36,39,41,42,46,47,51 .…”

Section: Resultsmentioning

confidence: 94%

“…Following DIO intervention, IL‐6 was higher in males compared with females by approximately 2.6‐fold according to seven (4%) studies, 23,30,34,45–48 whereas no sex differences were reported in 15 (65%) studies 31,33,35–42,49–53 . In females, IL‐6 increased by 1.4‐ to 5.2‐fold after DIO according to nine (50%) studies, 33,37,38,40,45,48–50,52 whereas another nine studies observed a neutral effect 34–36,39,41,42,46,47,51 . In males, IL‐6 increased by 1.4‐ to 3.6‐fold after DIO according to six (35%) studies, 33,38,40,45,46,52 whereas 11 (65%) studies observed a neutral effect 34–37,39,41,42,47,49–51 …”

Section: Resultsmentioning

confidence: 96%

Sex differences in systemic inflammation and immune function in diet‐induced obesity rodent models: A systematic review

Braga Tibaes,

Barreto Silva,

Wollin

et al. 2023

Obesity Reviews

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SummaryUnderstanding sex differences in immunological responses in the context of obesity is important to improve health outcomes. This systematic review aimed to investigate sex differences in systemic inflammation, immune cell phenotype, and function in diet‐induced obesity (DIO) animal models. A systematic search in Medline, Embase, and CINAHL from inception to April 2023 was conducted, using a combination of the following concepts: sex, obesity, cytokines, and immune cell phenotypes/function. Forty‐one publications reporting on systemic inflammation (61%), cell phenotype (44%), and/or function (7%) were included. Females had lower systemic inflammation compared with males in response to DIO intervention and a higher proportion of macrophage (M)2‐like cells compared with males that had a higher proportion of M1‐like in adipose tissue. Although there were no clear sex differences in immune function, high‐fat DIO intervention remains an important factor in the development of immune dysfunction in both males and females, including disturbances in cytokine production, proliferation, and migration of immune cells. Yet, the mechanistic links between diet and obesity on such immune dysfunction remain unclear. Future studies should investigate the role of diet and obesity in the functionality of immune cells and employ adequate methods for a high‐quality investigation of sex differences in this context.

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“…First, the results are from only male mice although the gut microbiome is known to be sexually dimorphic [ 74 ]. The present study focused on male mice because obesity caused by a high fat diet is sexually dimorphic [ 75 ] such that female B6 mice gain less weight than male B6 mice [ 76 ]. Second, the administration of morphine in the absence of acute or chronic nociception does not emulate clinical scenarios.…”

Section: Discussionmentioning

confidence: 99%

Morphine and high-fat diet differentially alter the gut microbiota composition and metabolic function in lean versus obese mice

Blakeley-Ruiz

McClintock²,

Shrestha³

et al. 2022

ISME Communications

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There are known associations between opioids, obesity, and the gut microbiome, but the molecular connection/mediation of these relationships is not understood. To better clarify the interplay of physiological, genetic, and microbial factors, this study investigated the microbiome and host inflammatory responses to chronic opioid administration in genetically obese, diet-induced obese, and lean mice. Samples of feces, urine, colon tissue, and plasma were analyzed using targeted LC-MS/MS quantification of metabolites, immunoassays of inflammatory cytokine levels, genome-resolved metagenomics, and metaproteomics. Genetic obesity, diet-induced obesity, and morphine treatment in lean mice each showed increases in distinct inflammatory cytokines. Metagenomic assembly and binning uncovered over 400 novel gut bacterial genomes and species. Morphine administration impacted the microbiome’s composition and function, with the strongest effect observed in lean mice. This microbiome effect was less pronounced than either diet or genetically driven obesity. Based on inferred microbial physiology from the metaproteome datasets, a high-fat diet transitioned constituent microbes away from harvesting diet-derived nutrients and towards nutrients present in the host mucosal layer. Considered together, these results identified novel host-dependent phenotypes, differentiated the effects of genetic obesity versus diet induced obesity on gut microbiome composition and function, and showed that chronic morphine administration altered the gut microbiome.

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Effects of high fat diets and supplemental tart cherry and fish oil on obesity and type 2 diabetes in male and female C57BL/6J and TALLYHO/Jng mice

Cited by 9 publications

References 54 publications

RETRACTED: Efficacy of Vanadyl Sulfate and Selenium Tetrachloride as Anti-Diabetic Agents against Hyperglycemia and Oxidative Stress Induced by Diabetes Mellitus in Male Rats

RETRACTED: Efficacy of Vanadyl Sulfate and Selenium Tetrachloride as Anti-Diabetic Agents against Hyperglycemia and Oxidative Stress Induced by Diabetes Mellitus in Male Rats

Sex differences in systemic inflammation and immune function in diet‐induced obesity rodent models: A systematic review

Morphine and high-fat diet differentially alter the gut microbiota composition and metabolic function in lean versus obese mice

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