Effects of high fat, protein supplemented diets on maternal behavior in rats

Bertino, Mary

doi:10.1016/0031-9384(82)90290-6

Cited by 16 publications

(8 citation statements)

References 17 publications

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“…Moreover, maternal attentiveness is associated with improved plasticity in the hippocampus in response to stress and enhanced contextual fear conditioning (Bagot et al, 2009). In rodent models, maternal HFD consumption increases nursing behaviors (Bertino, 1982; Connor et al, 2012; Purcell et al, 2011), and some evidence suggests that it decreases grooming behaviors (Connor et al, 2012). In our nonhuman primate model, we also see an increase in nursing and decrease in grooming behaviors among our HFD fed mother-infant pairs (Sullivan et al, in preparation).…”

Section: Mechanisms By Which Maternal High-fat Diet Consumption mentioning

confidence: 99%

Maternal high-fat diet programming of the neuroendocrine system and behavior

Sullivan

Riper

Lockard

et al. 2015

Hormones and Behavior

148

108

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Maternal obesity, metabolic state, and diet during gestation have profound effects on offspring development. The prevalence of neurodevelopmental and mental health disorders has risen rapidly in the last several decades in parallel with the rise in obesity rates. Evidence from epidemiological studies indicates that maternal obesity and metabolic complications increase the risk of offspring developing behavioral disorders such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD), and schizophrenia. Animal models show that a maternal diet high in fat similarly disrupts behavioral programming of offspring, with animals showing social impairments, increased anxiety and depressive behaviors, reduced cognitive development, and hyperactivity. Maternal obesity, metabolic conditions, and high fat diet consumption increase maternal leptin, insulin, glucose, triglycerides, and inflammatory cytokines. This leads to increased risk of placental dysfunction, and altered fetal neuroendocrine development. Changes in brain development that likely contribute to the increased risk of behavioral and mental health disorders include increased inflammation in the brain, as well as alterations in the serotonergic system, dopaminergic system and hypothalamic pituitary adrenal (HPA) axis.

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Section: Mechanisms By Which Maternal High-fat Diet Consumption mentioning

confidence: 99%

Maternal high-fat diet programming of the neuroendocrine system and behavior

Sullivan

Riper

Lockard

et al. 2015

Hormones and Behavior

148

108

View full text Add to dashboard Cite

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“…Research from rodent models reveals that consumption of a HFD increases nursing [50, 51] and grooming [50]. Higher grooming rates have been documented in rodent models to have a beneficial effect on offspring behavior [38, 52], yet the consequences of increased nursing have not been well characterized.…”

Section: 0 Hfd Consumption Impacts Offspring Behavior By Modifying mentioning

confidence: 99%

Maternal high fat diet consumption during the perinatal period programs offspring behavior

Sullivan

Nousen

Chamlou

2014

Physiology & Behavior

185

154

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The environment that developing offspring experience during the perinatal period is markedly influenced by maternal health and diet composition. Evidence from both epidemiological studies and animal models indicates that maternal diet and metabolic status play a critical role in programming the neural circuitry that regulates behavior, resulting in long-term consequences for offspring behavior. Maternal diet and metabolic state influence the behavior of offspring directly by impacting the intrauterine environment and indirectly by modulating maternal behavior. The mechanisms by which maternal diet and metabolic profile shape the perinatal environment remain largely unknown, but recent research has found that increases in inflammatory cytokines, nutrients (glucose and fatty acids), and hormones (insulin and leptin) affect the environment of the developing offspring. Offspring exposed to maternal obesity and high fat diet consumption during development are more susceptible to developing mental health and behavioral disorders such as anxiety, depression, attention deficit hyperactivity disorder, and autism spectrum disorders. Recent evidence suggests that this increased risk for behavioral disorders is driven by modifications in the development of neural pathways involved in behavioral regulation. In particular, research indicates that the development of the serotonergic system is impacted by exposure to maternal obesity and high fat diet consumption, and this disruption may underlie many of the behavioral disturbances observed in these offspring. Given the high rates of obesity and high fat diet consumption in pregnant women, it is vital to examine the influence that maternal nutrition and metabolic profile have on the developing offspring.

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“…Each animal was observed once every 5 min for a total of 12 recorded observations/hour. A checklist was used, adapted from that described by Bertino [3]. Items recorded were: nursing, resting with pups, resting without pups, grooming, pup grooming, object manipulation, loc omotion, eating, drinking, and time away from litter.…”

Section: Controls Jor General Disruptive Effects Of Dfchhf-s-ornithinmentioning

confidence: 99%

Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats

Fahrbach

Morrell

Pfaff³

1985

Neuroendocrinology

320

174

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Intracerebroventricular (i.c.v.) infusions of oxytocin (OXY) induce short-latency maternal behavior in estrogen-primed virgin rats. To investigate if brain OXY might have a role in the onset of maternal behavior at parturition, we have used both antisera to OXY and an analog antagonist of OXY, d(CH2)5–8-ornithine-vasotocin, to reduce the activity of endogenous OXY in a pregnancy-terminated preparation which yields reliable short-latency maternal behavior. Sprague-Dawley rats with lateral ventricle cannulae were ovariectomized and hysterectomized on day 16 of gestation; maternal behavior was stimulated by a s.c. injection of estradiol benzoate (EB). Effects of the i.c.v. infusion of antisera to OXY or of the i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin on the latency to respond to pups were tested by presenting pups 48 h after surgery and EB treatment. Behavioral observations were made for the next 5 h and periodically over the next 5 days. Groups receiving either the antisera to OXY or the analog antagonist had significantly longer latencies to respond to pups than did control groups. In a separate experiment, i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin was shown to have no effect on the performance of maternal behavior in lactating rats 5 days postpartum. These results suggest that OXY may have a role in promoting short-latency maternal behavior in steroid-primed female rats, but that it is probably not involved in sustaining this behavior during lactation.

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Effects of high fat, protein supplemented diets on maternal behavior in rats

Cited by 16 publications

References 17 publications

Maternal high-fat diet programming of the neuroendocrine system and behavior

Maternal high-fat diet programming of the neuroendocrine system and behavior

Maternal high fat diet consumption during the perinatal period programs offspring behavior

Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats

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