Effects of high-fluoride dentifrice (5,000-ppm) on caries-related plaque and salivary variables

Mannaa, Alaa; Carlén, Anette; Zaura, Egija; Buijs, M.J.; Bukhary, Sahar; Lingström, Peter

doi:10.1007/s00784-013-1119-8

Cited by 15 publications

(15 citation statements)

References 31 publications

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“…The plaque index in the group with 5,000 F was significantly reduced compared to the group with 1,100 ppm F Mannaa et al 2014a To measure the effects of a toothpaste containing 5,000 ppm F on caries-related factors in dental plaque and saliva 6 weeks longitudinally on mothers with an average age of 38.4 years (n = 17) and 17 teenagers with an average age of 14.5 years (n = 17) Sampling of approximal fluid for fluoride analysis and approximal plaque for organic acid analysis was performed Counts of cariogenic microorganism were performed at each of 4 visits Six weeks' use of toothpaste containing 5,000 ppm F significantly increased the approximal fluid F concentration (p < 0.05) Changes in interproximal plaque acidogenicity were noted, including significant reductions in AUC (5.7 and 6.2, respectively) and maximum pH fall and an increase in minimum pH (p < 0.05) A significant increase in the salivary buffer capacity and a reduction in the salivary mutans streptococci were observed (p < 0.05) Mannaa et al 2014b To assess the caries risk following 6 weeks' use of toothpaste containing 5,000 ppm F using 'Cariogram' software 6 weeks longitudinally on 17 mothers with an average age of 38.4 years (n = 17) and teenagers with an average age of 14.5 years (n = 17) Mutans streptococci and lactobacilli counts were performed at each of 4 visits A statistically significant linear trend was observed for mutans streptococci counts (p < 0.01) and the number of subjects with a salivary concentration of mutans streptococci <10 3 increased at each visit; the same trend was also observed for lactobacilli and buffer capacity scores (p = 0.04 and p = 0.03, respectively)…”

Section: Discussionmentioning

confidence: 87%

“…concentration in plaque after the use of 5,000 ppm toothpaste reached the level of around 14 ppm F, while the corresponding value after the use of toothpaste with 1,450 ppm F was around 10 ppm. Mannaa et al [2014a, b] even found that the pH dropped less after rinsing with 10% sucrose solution when tooth brushing was performed using 5,000 ppm toothpaste compared to toothpaste with 1,450 ppm F. Thus, even though the fluoride concentration in plaque does not reach 10 ppm for a longer period, it seems that the higher concentration of fluoride changes the cariogenic potential in the plaque, perhaps by decreasing the number of lactate-forming microorganisms [Mannaa et al 2014b], which then results in the pH not dropping so low after a cariogenic rinsing in 10% sucrose. This may also explain that Lynch et al [2000], Baysan et al [2001] and found lower plaque scores after the use of 5,000 ppm toothpaste compared to toothpaste with 1,450 ppm F ( table 2 ).…”

Section: Discussionmentioning

confidence: 99%

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High Fluoride Dentifrices for Elderly and Vulnerable Adults: Does It Work and if So, Then Why?

Ekstrand¹

2016

Caries Res

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The primary aim of this work is to present the available evidence that toothpastes containing >1,500 ppm fluoride (2,500-2,800 and 5,000 ppm F) provide an additional caries preventive effect on root caries lesions in elderly patients compared to traditional dentifrices (1,000-1,450 ppm F). The secondary aim of this paper is to discuss why high fluoride dentifrices in general should perform better than traditional F-containing toothpaste. When examining the few studies that have considered the preventive benefits of high fluoride products on root caries the relative risk appears to be around 0.5, and the risk can thus be halved by exchanging traditional F-containing toothpaste for toothpaste containing 5,000 ppm F. There is reasonable evidence that high fluoride dentifrices significantly increase the fluoride concentration in saliva during the day and the fluoride concentration in plaque compared to traditional F toothpaste. Furthermore, the use of toothpaste with 5,000 ppm F significantly reduces the amount of plaque accumulated, decreases the number of mutans streptococci and lactobacilli and possibly promotes calcium fluoride deposits to a higher degree than after the use of traditional F-containing toothpaste.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

High Fluoride Dentifrices for Elderly and Vulnerable Adults: Does It Work and if So, Then Why?

Ekstrand¹

2016

Caries Res

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“…This phenomenon is reported to be significantly associated with the widespread use of fluoride (F − ) toothpaste (Walsh, Worthington, Glenny, Marinho, & Jeroncic, ). It is known that a toothpaste with higher fluoride concentration has a greater effect in preventing dental caries (Mannaa et al, ; Walsh et al, ). Although the prevalence of dental caries has decreased, the interproximal surface is still a high‐risk site of dental caries (Haak, Wicht, Hellmich, Gossmann, & Noack, ).…”

Section: Introductionmentioning

confidence: 99%

Modified toothpaste application using prepared toothpaste delivering technique increases interproximal fluoride toothpaste delivery

Satou

Suzuki

Takayanagi

et al. 2019

Clinical & Exp Dental Res

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Objectives We devised a “prepared toothpaste delivering technique” (PTD technique), a modified the application of toothpaste method for using fluoride toothpaste more effectively. This study aimed to investigate the change in viscosity and fluoride intake into hydroxyapatite of a toothpaste, and deliverability of fluoride toothpaste to the interproximal site with the PTD technique using an interproximal model. Methods Eight toothpaste samples were prepared at the following concentrations: ×1.00, ×1.25, ×1.50, ×1.75, ×2.00, ×3.00, ×4.00, and ×5.00. Viscosity of the toothpaste was measured by a Type‐B viscometer. Dissolution rate of toothpaste and fluoride uptake into the hydroxy apatite pellet were analyzed by a fluoride selective electrode. Application paste volume and delivery rate was measured using interproximal model and image analysis software during using a finger brush front (FBF), finger brush back (FBB), and toothbrush. Results As the dilution ratio increased, the viscosity of the toothpaste decreased sharply, F uptake decreased, and dissolution rate increased. F uptake was significantly reduced when the toothpaste was diluted more than 1.75 times. Therefore, in order to improve the effectiveness of the fluoride toothpaste, it is important to deliver the toothpaste to interproximal areas and pit clefts at low dilution. It was observed that PTD technique can be effectively implemented by the finger brush. Conclusions The use of a FBF surface in the analysis of an acrylic interproximal model could aid in applying pressure while blocking the space of the groove and preventing outflow of the toothpaste. It was considered that the PTD technique would improve the effects of the fluoride toothpaste, especially in the interproximal site.

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“…Little is however known on the long-term impact of such fluoride-based programs on oral bacteria. It is generally thought that a low-fluoride exposure can interact with the consecutive cycles of de- and remineralization while higher fluoride concentrations may hamper bacterial acid production [7, 8]. A reduced pH-drop would favour the growth of health-associated bacteria that prefer pH values around neutrality rather than the acid-producing and acid-tolerating species associated with caries [9].…”

Section: Introductionmentioning

confidence: 99%

Oral microflora in preschool children attending a fluoride varnish program: a cross-sectional study

et al. 2016

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BackgroundTo compare the oral microflora in preschool children attending a fluoride varnish program with a reference group receiving a standard oral health program without fluoride varnish applications. A second aim was to relate the microbial composition to the caries prevalence.MethodsFive hundred seven 3-year-old children were enrolled from a cohort of 3403 preschool children taking part in a community based oral health project. Two hundred sixty-three of them had attended caries-preventive program with semi-annual applications of a fluoride varnish since the age of 1 year (test group) while 237 had received standard preventive care (reference group). Oral samples were collected with a sterile swab and analysed with checkerboard DNA-DNA hybridization using 12 pre-determined bacterial probes. Caries and background data were collected from clinical examinations and questionnaires.ResultsGram-positive streptococci (S. intermedius, S. salivarius, S. oralis) were most frequently detected and displayed the highest counts in both groups. There were no significant differences between the groups concerning prevalence of any of the selected bacterial strains except for S. oralis that occurred less frequently in the reference group. In children with caries, V. parvula were significantly more common (p < 0.05) while strains of Lactobacillus, Bifidobacterium and Neisseria were more prevalent among the caries-free children (p < 0.05).ConclusionsA 2-year community program with semi-annual fluoride varnish applications did not seem to significantly influence the oral microflora in preschool children.Trial registration www.controlled-trials.com (ISRCTN35086887) 20131216 ‘retrospectively registered’.

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Effects of high-fluoride dentifrice (5,000-ppm) on caries-related plaque and salivary variables

Abstract: The 5,000-ppm F toothpaste could be regarded as a possible effective regimen against caries in the near future.

Cited by 15 publications

References 31 publications

High Fluoride Dentifrices for Elderly and Vulnerable Adults: Does It Work and if So, Then Why?

High Fluoride Dentifrices for Elderly and Vulnerable Adults: Does It Work and if So, Then Why?

Modified toothpaste application using prepared toothpaste delivering technique increases interproximal fluoride toothpaste delivery

Oral microflora in preschool children attending a fluoride varnish program: a cross-sectional study

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