Effects of high-intensity interval training on health-related quality of life in chronic lymphocytic leukemia: A pilot study

High-Intensity Interval Training and Strength Conditioning in patients with Chronic Lymphocytic Leukemia: a systematic review.

“…In the studies included, physical activity with different types and intensities (aerobic, strength, resistance and HIIT) were objectively assessed. Because CLL exercise intervention remains an unclear eld of expertise, literature addressing PA in uence in CLL (exclusively) disease parameters is rare (only three small Pilot Studies with 24 patients [35], 16 patients [36] and 15 patients [37]), reason that led us to select for inclusion any exercise intervention study that could be related to CLL in adults [38][39][40]. Table 1 summarizes the quality assessment of each study, according to STROBE guidelines [33], and the risk of BIAS was based on the 9th point of the referred guidelines.…”

“…It was reported in a small cohort with 12 patients with hematologic disease (7 patients with Acute Myeloid Leukemia, 1 Acute Lymphoblastic Leukemia and 4 Non-Hodgkin's Lymphoma) receiving high-dose chemotherapy, that none of the patients with thrombocyte counts below 10.000/µl suffered bleeding and no patient with haemoglobin counts below 8 g/dl suffered critical tachycardias, showing that physical exercise in patients with severe cytopenia is safe and results in increased physical performance and unchanged quality of life [53]. Also in the studies we collected, the feasibility of the intervention protocols were always highly rated, with 99 ± 3,6% attendance and 148,5 ± 5,4 min/week of exercise and with 100% safety [36, 37,40]; with 91% attendance with 88 ± 17 min/week (Furzer et al, 2016); with small adverse events related with intervention protocol such as back, hip and knee pain (Courneya et al, 2009) but without impairment of patients maintenance on the protocol.…”

“…Time for inclusion after diagnosis ranged between 2,1 ± 2,6 and 7,9 ± 9,1 years. In the two studies that engaged CLL patients without previous treatment[36,37], patients recruited were in Rai stage 0 or I (83,3% of patients in intervention group and 80% in control group, remaining percentage are described as unknown) or CLL-IPI stage 0-1 and 2-3 (50% of patients in intervention group and 30% in control group, remaining percentage are described as unknown). In the remaining studies this information is not addressed by the authors.…”

“…the studies with intervention protocols available, one was based only on recumbent cycle ergometer training, regarding heart rate reserve as modulator of intensity[38], three studies with HIIT exclusively during 30min, or with 1h combining 30min HIIT plus 30min resistance training[36,37,40], and another study using continuous cardiovascular training concomitant with resistance training[39]. However, because there is a combination of Continuous Cardiovascular (or HIIT) plus RT, we cannot fully establish a relation between resistance/strength training only, and cardiovascular only, or the combined effect of training in CLL patients, neither infer about the difference between endurance and strength training in resistance training protocols.…”

Chronic Lymphocytic Leukemia: Time to Care for the Survivors

“…A small nonrandomized study evaluated a 12-week high-intensity interval and resistance training program in patients with treatment-na ïve CLL (median age 64 years), reporting a benefit in functional well-being and CLL-specific symptoms. 64 Further studies are needed to assess this safe and widely accessible intervention.…”