Effects of high-intensity training on cardiovascular risk factors in premenopausal and postmenopausal women

Mandrup, Camilla M.; Egelund, Jon; Nyberg, Michael; Slingsby, Martina H. Lundberg; Andersen, Camilla Fuchs; Løgstrup, Sofie; Bangsbo, Jens; Suetta, Charlotte; Stallknecht, Bente; Hellsten, Ylva

doi:10.1016/j.ajog.2016.12.017

Cited by 68 publications

(96 citation statements)

References 30 publications

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“…It is important to point out that BP data were previously reported on these groups of women and were found to be unaltered with training. 34 The reason for this discrepancy is likely that the number of included participants was lower in the present group and there was a slight difference in statistical approach.…”

Section: Participant Characteristicsmentioning

confidence: 75%

“…There was a decrease ( P= 0.0001) in resting HR after the training period in the postmenopausal group (5.2%), but the change in HR at rest in the premenopausal group did not reach statistical significance. Data on low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and triglycerides are presented elsewhere …”

Section: Resultsmentioning

confidence: 99%

“…The training sessions were characterized by ≈50 minutes of intermittent high‐intensity intervals where the participants reached HRs over 85% of maximum HR (Table ). For more information and details on the participants’ variation in exercise intensities during the training see Nyberg et al and Mandrup et al …”

Section: Methodsmentioning

confidence: 99%

“…A total of 83 participants (43 premenopausal and 40 postmenopausal) were initially recruited. A CONSORT flow diagram for the participants has been included in Mandrup et al 34 Ten participants were either excluded or dropped out because of illness (1), during run-in (4), because of insufficient training adherence (2), and because of pregnancy (1). Two premenopausal women were not assessed by echocardiography for logistic reasons.…”

Section: Participant Characteristicsmentioning

confidence: 99%

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Cardiac Adaptations to High‐Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study

Egelund

Jørgensen

Mandrup

et al. 2017

JAHA

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BackgroundWe examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause.Methods and ResultsTwo groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular disease and with a mean age difference between groups of only 4 years were studied. Cardiac dimensions and systolic and diastolic function were determined by transthoracic echocardiography with tissue Doppler imaging and 2‐dimensional speckle tracking. Measurements were performed at baseline and after a 12‐week period of high‐intensity aerobic cycle training. LV internal diastolic diameter and LV mass were similar in the 2 groups at baseline and increased by ≈2% to 8% (P=0.04–0.0007) with training in both groups. Left atrial end‐diastolic and end‐systolic volumes were similar for both groups and increased by 23% to 36% (P=0.0006–0.0001) with training. Systolic function assessed by mean global strain was similar in both groups at baseline and increased by ≈8% (P=0.0004) with training in the postmenopausal group. LV displacement increased by ≈3% (P=0.04) in the premenopausal women only. Diastolic function assessed by E/A ratio was similar at baseline and increased by ≈7% (P=0.01) in the premenopausal group and 11% (P=0.0001) in the postmenopausal group with training.ConclusionsThese results suggest that training‐induced cardiac adaptations are preserved in the early postmenopausal phase. Furthermore, the hormonal changes associated with the menopausal transition do not appear to affect cardiac dimensions and function.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02135575.

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Section: Participant Characteristicsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Participant Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Cardiac Adaptations to High‐Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study

Egelund

Jørgensen

Mandrup

et al. 2017

JAHA

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“…This study investigated the research questions by using samples from two separate studies with the aim of investigating the effects of floorball and spinning, respectively, on participants' cardiovascular and musculoskeletal health; the details as well as the results of studies are reported elsewhere (Mandrup, et al, 2017;Nyberg, et al, 2014). The studies were approved by the Ethics Committee of Copenhagen and Frederiksberg communities Region H (H-1-2012-150) and conducted in accordance with the guidelines of the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Are team sport games more motivating than individual exercise for middle-aged women?

Wikman

Elsborg

Nielsen

et al. 2018

Kinesiology (Zagreb, Online)

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Abstract:The aim of this study was to investigate the levels of motivation associated with the participation in floorball (indoor hockey) and spinning, and how these levels of motivation predicted continuation. A sample of 66 middle-aged women participated in a 12-week intervention of either floorball or spinning. They filled out the Sport Motivation Scale in week 2 and week 11 of the intervention, and data was also collected on their continuation six and 12 months after the intervention. A repeated measures MANOVA showed that participants in the floorball group had higher levels of intrinsic and self-determined extrinsic motivation for the activity during the intervention period, suggesting that floorball is a more motivating activity. In addition, the introjected regulation extrinsic motivation increased in both groups during the intervention period. Intrinsic motivation, as well as extrinsic motivation introjected regulation, predicted participants' continuation six and 12 months after the intervention, suggesting that motivation as viewed in a Self-Determination Theory perspective is important for exercise continuation.

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The physiological impact of high‐intensity interval training in octogenarians with comorbidities

Blackwell

Gharahdaghi

Brook

et al. 2021

J cachexia sarcopenia muscle

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Background Declines in cardiorespiratory fitness (CRF) and fat‐free mass (FFM) with age are linked to mortality, morbidity and poor quality of life. High‐intensity interval training (HIIT) has been shown to improve CRF and FFM in many groups, but its efficacy in the very old, in whom comorbidities are present is undefined. We aimed to assess the efficacy of and physiological/metabolic responses to HIIT, in a cohort of octogenarians with comorbidities (e.g. hypertension and osteoarthritis). Methods Twenty‐eight volunteers (18 men, 10 women, 81.2 ± 0.6 years, 27.1 ± 0.6 kg·m−2) with American Society of Anaesthesiology (ASA) Grade 2–3 status each completed 4 weeks (12 sessions) HIIT after a control period of equal duration. Before and after each 4 week period, subjects underwent body composition assessments and cardiopulmonary exercise testing. Quadriceps muscle biopsies (m. vastus lateralis) were taken to quantify anabolic signalling, mitochondrial oxidative phosphorylation, and cumulative muscle protein synthesis (MPS) over 4‐weeks. Results In comorbid octogenarians, HIIT elicited improvements in CRF (anaerobic threshold: +1.2 ± 0.4 ml·kg−1·min−1, P = 0.001). HIIT also augmented total FFM (47.2 ± 1.4 to 47.6 ± 1.3 kg, P = 0.04), while decreasing total fat mass (24.8 ± 1.3 to 24 ± 1.2 kg, P = 0.0002) and body fat percentage (33.1 ± 1.5 to 32.1 ± 1.4%, P = 0.0008). Mechanistically, mitochondrial oxidative phosphorylation capacity increased after HIIT (i.e. citrate synthase activity: 52.4 ± 4 to 67.9 ± 5.1 nmol·min−1·mg−1, P = 0.005; membrane protein complexes (C): C‐II, 1.4‐fold increase, P = 0.002; C‐III, 1.2‐fold increase, P = 0.03), as did rates of MPS (1.3 ± 0.1 to 1.5 ± 0.1%·day−1, P = 0.03). The increase in MPS was supported by up‐regulated phosphorylation of anabolic signalling proteins (e.g. AKT, p70S6K, and 4E‐BP1; all P < 0.05). There were no changes in any of these parameters during the control period. No adverse events were reported throughout the study. Conclusions The HIIT enhances skeletal muscle mass and CRF in octogenarians with disease, with up‐regulation of MPS and mitochondrial capacity likely underlying these improvements. HIIT can be safely delivered to octogenarians with disease and is an effective, time‐efficient intervention to improve muscle mass and physical function in a short time frame.

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Effects of high-intensity training on cardiovascular risk factors in premenopausal and postmenopausal women

Cited by 68 publications

References 30 publications

Cardiac Adaptations to High‐Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study

Cardiac Adaptations to High‐Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study

Are team sport games more motivating than individual exercise for middle-aged women?

The physiological impact of high‐intensity interval training in octogenarians with comorbidities

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