Effects of high progesterone on outcomes of<i>in vitro</i>fertilization-embryo transfer in patients with different ovarian responses

Li, Pengfen; Zhu, Hong; Tan, Li; Ma, Liying; Xiang, Yang; Zhang, Dan; Dou, Qian; Lu, Na

doi:10.3109/19396368.2015.1033779

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…For those patients, researchers have suggested frozen-thawed embryo transfer or blastocyst transfer. Li et al have demonstrated the effect of high progesterone levels on outcomes of in vitro fertilization-embryo transfer in patients with different ovarian responses (26). They defined a P cut-off value of 2.5 ng/ml in the high ovarian response group, 2.25 ng/ml in the moderate ovarian response group and 1.5 ng/ml in the low ovarian response group.…”

Section: Discussionmentioning

confidence: 99%

Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Wang

et al. 2017

Biomedical Reports

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Abstract. The aim of the present study was to evaluate the factors that affect the success rate of gonadotropin-releasing hormone antagonist on in vitro fertilization/intracytoplasmic sperm injection cycles. Multivariate analysis was performed to assess the factors that influence the outcomes, such as oocytes retrieved, and the success of pregnancy. The results showed that E 2 , P on human chorionic gonadotropin (HCG) day and body mass index (BMI) were positively correlated with the number of oocytes retrieved (P=0.001, P=0.024, P=0.017, respectively). The duration of infertility as well as the luteinizing hormone on HCG day were negatively correlated with the number of oocytes (P=0.048, P=0.002, respectively). The age of the women and P on HCG day were negatively correlated with successful pregnancy (P<0.001, P=0.022). In conclusion, some parameters, such as E 2 , P, and LH on the HCG day, as well as age and BMI, may affect treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Wang

et al. 2017

Biomedical Reports

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“…Although GnRH analogues are frequently used in COS for IVF/ICSI cycles, an elevation in blood P4 levels is frequently noticed near the follicular phase's end. For a number of years, the clinical effect of premature progestrone rise has been extremely contentious, a study's showing that there is no connection between P4 levels and rates of conception (9) , whereas some have noticed a negative impact on cycle results (10,11) .…”

Section: Discussionmentioning

confidence: 99%

Effect of High Progesterone Level on Day of Human Chrionic Gonadotropin Triggering on Pregnancy Rate in Frozen Embryo Transfer

Elsayed¹,

Hafez²,

Abdelmoaty³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: The endometrial morphology and receptivity, the embryo implantation procedure and the success rate of In vitro fertilization (IVF) are all significantly influenced by progesterone. The increased progesterone adversely affected the endometrial environment of fresh cycles, reducing the chance of pregnancy. However, the embryo quality is equally as crucial to the embryo-endometrial cross-dialog as endometrial receptivity, based on the rate of pregnancy in frozen cycles. Objective: The aim of the current study was to determine how Day of human chorionic gonadotropin (HCG) was impacted by early progesterone rise. Patients and methods: A retrospective cohort research was conducted in the Obstetrics and Gynaecology Department of the Zagazig University Hospital. The study included records of all cases fulfilling the next inclusion criteria: Women with any type of subfertility who underwent frozen embryo transfer, Age less than 40 years old, gonadotropin-releasing hormone (GnRH) antagonist stimulation protocol in fresh Intracytoplasmic Sperm Injection (ICSI) cycle, Basal serum follicle stimulating hormone (FSH) concentration less than 15 mIU/mL. Over 5 years, 200 records were included as a comprehensive sample undergoing ICSI and subsequent frozen embryo. Results: Using a threshold value for serum progesterone previously described of 1.5 ng/ml, 142 from 200 (71%) frozen embryo transfers that involved the transfer of embryos from low progesterone level ICSI cycles, and 58 from 200 (29%) frozen embryo transfers in which embryos from elevated progesterone level. The evolution of pregnancy outcomes following ICSI cycles demonstrated that there was no discernible difference between the groups with higher blood levels. Conclusion: Elevated progesterone levels on the day of HCG do not negatively affect pregnancy outcomes in frozen cycles triggering.

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“…In our study, only patients showing a normal ovarian response were included; a poor or high ovarian response may affect the E2 levels, P levels, laboratory outcomes, and clinical outcomes [ 33 – 37 ]. Moreover, the stimulation protocols and dose of treatment may vary greatly between patients with poor or high ovarian response.…”

Section: Discussionmentioning

confidence: 99%

Effects of reduced follicle-stimulating hormone dosage before human chorionic gonadotropin trigger on in vitro fertilization outcomes

Ou,

Du,

Liu

et al. 2023

BMC Pregnancy Childbirth

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Objective To determine whether a reduced dose of follicle-stimulating hormone (FSH) before human chorionic gonadotropin (hCG) trigger during ovarian stimulation can affect in vitro fertilization (IVF) outcomes. Methods This study included 347 patients with a normal ovarian response who received a reduced dose of FSH before hCG trigger for 2–3 days (Group A) and 671 patients who did not receive a reduced dose (Group B) from a university-affiliated IVF center between January 2021 and December 2022. The primary endpoint was estrogen (E2) and progesterone (P) levels on the day of hCG trigger, fresh embryo transfer cycles, laboratory outcomes, and clinical outcomes between the two groups. Results On the day of hCG trigger, Group A had significantly lower E2 and P levels than those in Group B (3454.95 ± 1708.14 pg/mL versus 3798.70 ± 1774.26 pg/mL, p = 0.003; and 1.23 ± 0.53 ng/mL versus 1.37 ± 0.59 ng/mL, p < 0.001, respectively). The proportion of patients with P levels ≥ 1.5 ng/mL was 22.48% in Group A compared to 34.58% in Group B (p < 0.001), while the proportion of patients with E2 ≥ 5000 pg/mL was 15.27% in Group A compared to 25.93% in Group B (p < 0.001). The fresh embryo-transfer cycle rate in Group A was higher than that in group B (54.47% and 32.64%, respectively; p < 0.001). Despite the reduction in FSH dosage, there were no significant differences between groups regarding the number of oocytes retrieved, total number of mature oocytes, normal fertilization rate, cleavage rate, Day 3 top-quality rate, implantation rate, pregnancy rate per cycle, and early pregnancy loss rate. Conclusion While a reduced dose of FSH prior to hCG trigger during ovarian stimulation did not significantly affect IVF outcomes, it was associated with lower E2 and P levels, resulting in fewer cycles with E2 ≥ 5000 pg/mL and P ≥ 1.5 ng/mL on the day of the hCG trigger.

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Effects of high progesterone on outcomes ofin vitrofertilization-embryo transfer in patients with different ovarian responses

Cited by 10 publications

References 21 publications

Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Effect of High Progesterone Level on Day of Human Chrionic Gonadotropin Triggering on Pregnancy Rate in Frozen Embryo Transfer

Effects of reduced follicle-stimulating hormone dosage before human chorionic gonadotropin trigger on in vitro fertilization outcomes

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