In this research article, the irreversibility of Jeffery fluid in mixed convective flow with inclined channel under the influence of Navier‐slip condition is analyzed. The effects of Hall current, Soret number, and an inclined magnetic field are taken into account. The spectral quasi‐linearization method (SQLM) is used to solve the governing equations after transforming them into a dimensionless form. The impacts of various parameters on velocity, temperature, and concentration are examined graphically. With the use of tabular data, variations in skin friction, the Nusselt number, and the Sherwood number are also discussed. Our findings indicate that entropy production increases with higher values of the magnetic parameter, Hall current, and inclination angle. Conversely, we have observed an opposing trend with an increased value of slip condition at the left plate and the Jeffrey fluid parameter.