Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study

Kuwabara, Yoshitaka; Hirose, Akiko; Lee, Hyunjin; Kakinuma, Toshihiro; Baba, Asami; Takara, Tsuyoshi

doi:10.1080/19390211.2023.2185723

Cited by 4 publications

(3 citation statements)

References 51 publications

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“… 52 Clinically, consumption of curcumin supplement was reported to reduce common cold symptoms and shorten cold duration, although the inflammatory cytokine levels are highly variable in acute disease like the common cold. 53 Similar clinical anti- inflammatory actions by ginger were observed and exemplified in chronic and severe respiratory conditions. 54 , 55 Liquorice and peppermint were clinically demonstrated to be effective antitussive agents against cough 48 , 56 as well as to possess anti-inflammatory actions via corticosteroid-like activity 57 and IL-10 modulation, 58 respectively.…”

Section: Discussionmentioning

confidence: 57%

Treatment of the common cold with herbs used in Ayurveda and Jamu: monograph review and the science of ginger, liquorice, turmeric and peppermint

Wardani,

Schellack,

Govender

et al. 2023

DIC

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Background The common cold is typically managed with decongestants, antihistamines, antitussives and antipyretics. In addition to these established medications, herbal ingredients have been used over centuries to help treat common cold symptoms. The Ayurveda and Jamu systems of medicine, originating from India and Indonesia, respectively, have leveraged herbal therapies to treat many illnesses. Method An expert roundtable discussion comprising specialists in Ayurveda, Jamu, pharmacology and surgery along with a literature review was conducted to evaluate the use of four herbs – ginger, liquorice, turmeric and peppermint – for common cold symptom management in Ayurvedic texts, Jamu publications and monographs from the World Health Organization, Health Canada and various European guidelines. Discussion Due to a lack of antivirals, common cold management revolves around maintaining personal hygiene and symptom management. Herbal medicines have been an integral part of many cultures worldwide. Despite its growing acceptance, there is a perception that healthcare providers lack interest and may prevent patients from discussing the use of herbal medicines. Limited education and training may also widen the communication gap between patients and healthcare providers, hindering effective management. Conclusion Evaluation of scientific evidence and the standing in international monographs can offer perspectives on the use of herbal medicines for common cold management.

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Section: Discussionmentioning

confidence: 57%

Treatment of the common cold with herbs used in Ayurveda and Jamu: monograph review and the science of ginger, liquorice, turmeric and peppermint

Wardani,

Schellack,

Govender

et al. 2023

DIC

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“…Curcumin has been ingested for a long time, attracting attention as supplements for supporting health maintenance. Furthermore, curcumin is an ingredient used as a food with Health Claims (FHC) and has been proven to be safe in previous studies [8,45].…”

Section: Discussionmentioning

confidence: 99%

Improvement in autonomic balance through 12-week supplementation of a novel curcumin formulation in healthy Japanese adults: A randomized, placebo-controlled study

Yoshitaka,

Lee,

Hirose

et al. 2024

FFHD

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Background: Curcumin has several health benefits due to its potent antioxidant and anti-inflammatory properties, but its bioavailability is very low, limiting its potential. We have developed a novel curcumin formulation, TS-P1, which has an 85.2-fold higher bioavailability of curcumin than raw curcumin. Objective: To investigate the efficacy of TS-P1 on fatigue, mood status, and autonomic function. Methods: Ninety healthy Japanese adults were randomized to the placebo or TS-P1 group and took either the placebo or TS-P1 containing 150 mg of curcumin for 12 weeks. Visual Analogue Scale for Fatigue (VAS-F) scores, Profile of Mood States Questionnaire second edition (POMS2) scores, and autonomic functions were measured every 4 weeks. Results: Both groups showed an improvement in the VAS-F over the study period, but there was no significant difference between the placebo and TS-P1 groups. However, the mean change from baseline in the anger and depression scores of the POMS2, particularly in those aged 40 and over, in the TS-P1 group showed a greater range of decline at week 12. The mean change from baseline in LnLF and LF/HF also decreased in the TS-P1 group. Blood pressure also decreased in the TS-P1 group. Conclusions: These data suggest that TS-P1 induced a parasympathetic dominant state, and that curcumin has an important role in the regulation of autonomic balance. 12 weeks of supplementation of TS-P1 is expected to improve both mood status and vascular function. Trial registration: UMIN000050377 Foundation: Theravalues Corporation Keywords: curcumin; TS-P1: Theracurmin Super; mood status; autonomic balance, parasympathetic dominance; vascular function

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“…Moreover, the maximum number of days for which common cold symptoms persisted in the subjects during the intervention period, and the frequency with which subjects experienced them were assessed as secondary outcomes. These survey items were based on Kuwabara et al [23].…”

Section: Exclusion Criteriamentioning

confidence: 99%

Effects of sulforaphane glucosinolates from broccoli seed extract on the immune system of healthy Japanese adults

Kouno¹,

Suzuki²,

Takara

2023

FFHD

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Background: The Purpose of this study was to investigate the effects of sulforaphane glucosinolate (SGS) from broccoli seed extracts on immune function and common cold symptoms in healthy Japanese adults.Methods: This randomized, placebo-controlled, double-blind, parallel-group comparison study was conducted on Japanese adults who had worse health-related quality of life on the SF-8 and were more likely to catch colds from October 22, 2020 to April 2, 2021.Individuals who agreed to participate in the study were randomly assigned to either the SGS 100 mg/day group or the placebo group (n = 33 each). The intervention lasted 8 weeks. The outcomes of this study were the cumulative and the maximum number of days for which common cold symptoms persisted during the intervention period per subject (primary), and the frequency with which subjects experienced these symptoms per group (secondary). Additionally, the incidence rate of subjects infected with the influenza virus, immune indices, and SF-8 were assessed.Results: Based on a per protocol set, 64 subjects (33 in the SGS group and 31 in the placebo group) were analyzed. After the 8-week interventional period, the cumulative number of days for which common cold symptoms per subject was significantly lower for the SGS group than the placebo group (12.1 ± 13.5 for the SGS group and 20.2 ± 18.2 for the placebo group). The cumulative number of days of common cold symptoms per group was also significantly lower in the SGS group than in the placebo group (400 days in the SGS group and 626 days in the placebo group). No changes attributable to the SGS intervention were observed in the other outcomes. There were no adverse events due to food ingestion.Conclusion: A period of 8 weeks of SGS intake was shown to alleviate the onset of common cold symptoms in healthy Japanese adults who were prone to catching colds and had a low subjective sense of wellness.Keywords: Broccoli, sulforaphane, glucoraphanin, cold symptoms, immunityTrial registration: UMIN-CTR: UMIN000042195.Foundation: Murakami Farm Co., Ltd.

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Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study

Cited by 4 publications

References 51 publications

Treatment of the common cold with herbs used in Ayurveda and Jamu: monograph review and the science of ginger, liquorice, turmeric and peppermint

Treatment of the common cold with herbs used in Ayurveda and Jamu: monograph review and the science of ginger, liquorice, turmeric and peppermint

Improvement in autonomic balance through 12-week supplementation of a novel curcumin formulation in healthy Japanese adults: A randomized, placebo-controlled study

Effects of sulforaphane glucosinolates from broccoli seed extract on the immune system of healthy Japanese adults

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