Effects of Highly Polluted Environment on Sperm Telomere Length: A Pilot Study

Vecoli, Cecilia; Montano, Luigi; Borghini, Andrea; Notari, Tiziana; Guglielmino, Antonino; Mercuri, Antonella; Turchi, S.; Andreassi, Maria Grazia

doi:10.3390/ijms18081703

Cited by 36 publications

(30 citation statements)

References 27 publications

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“…Another one study showed that young male residents in areas with high environment exposure had a significantly increased telomere length in sperm. These findings support the view that semen is a sensitive sentinel biomarker of environmental exposure [8].…”

Section: Environmental Factors Influencing Male Infertility (Exogenousupporting

confidence: 86%

Impact of Environmental Factors on Male Reproductive Health

2020

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The aim of our work was to make analysis of world literature that develops a problem of impact of environment on male reproductive health. Materials and methods: We analyzed the bibliography available, until January 2020, about influence of different exogenic factors on male reproductive system. Conclusions: The biggest influence of ionizing radiation on mankind was reached after two big catastrophes: Chernobyl Nuclear Power Plant in April 1986 and an accident on the Fukushima Daiichi Nuclear Power Plant in March 2011. However, impact of ionizing radiation on male reproductive in literature still remains controversy that needs more detailed study. Lead influences on such sperm parameters, as sperm morphology, count, motility, semen volume. So, specific attention should be paid to the type of work routinely performed by man. Another one environmental factor that has negative influence is a heat. It effects on sperm morphology and motility.

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Section: Environmental Factors Influencing Male Infertility (Exogenousupporting

confidence: 86%

Impact of Environmental Factors on Male Reproductive Health

2020

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“…In total, 15 of the positively associated studies detected a sperm TL (STL) association (68-70,72,74-84), while 3 studies detected an LTL association (73,85,86), and one study detected both STL and LTL (71). In several studies, shorter STL was reported in association to infertility (72,76,78,80) while Vecoli et al reported an increase in STL in areas of high environmental exposure (77). Although Turner and Hartshorne found an association between female fertility and STL, they did not find a significant association for male fertility (39).…”

Section: Telomere Length and Male Infertilitymentioning

confidence: 99%

The association of female and male infertility with telomere length (Review)

et al. 2019

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Telomere length (TL) has long been associated with aging, as telomeres serve as protective caps of chromosomes, and are thus deeply involved in the preservation of genome integrity and are vital to cellular functions. Traditionally, a strong link connects aging and infertility in both sexes, with an earlier onset in females. Over the past decade, telomeres have attracted increasing attention due to the role they play in fertility. In this review, we investigated the potential positive or negative association between relative TL and different factors of female and male infertility. A systematic search of the PubMed database was conducted. Out of the 206 studies identified, 45 were reviewed as they fulfilled the criteria of validity and relevance. Following an analysis and a comparison of the study outcomes, several clear trends were observed. The majority of female infertility factors were associated with a shorter TL, with the exception of endometriosis, premature ovarian failure and clear cell carcinoma that were associated with a longer TL and polycystic ovary syndrome (PCOS), which revealed conflicting results among several studies, leading to ambiguous conclusions. Male infertility factors were associated with a shorter TL. Although this review can provide an outline of general trends in the association of TL with infertility factors, further epidemiological and original research studies are required to focus on investigating the basis of these varying lengths of telomeres. Contents 1. Introduction 2. Telomere length and female infertility 3. Telomere length and male infertility 4. Conclusions and future perspectives

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“…In patients with high BMI (>28 kg/m 2 ) compared with normal BMI, increased reactive oxygen species (ROS) activity in semen and sperm DNA fragmentation were found,these are factors linked to poorer sperm quality that may account for poorer IVF treatment outcomes 48,49. STL attrition is linked to ROS exposure in relation to environmental and lifestyle factors such as alcohol consumption and smoking [50][51][52]. However, Mishra and colleagues demonstrated that a mild increase in oxidative stress is beneficial for STL maintenance 53.…”

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confidence: 99%

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

et al. 2019

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Background: Many studies have demonstrated that lifestyle factors can affect sperm quality and fertility. Sperm telomere length (STL) has been reported as potential biomarker or sperm quality. However, no studies have investigated how lifestyle factors can affect STL and associated clinical outcomes. Objectives:The purpose of this manuscript is to investigate any association between STL with lifestyle factors, semen parameters and clinical outcomes. Materials and methods:Sperm telomere length was measured using real-time PCR in normozoospermic male partners (n = 66) of couples undergoing ART treatment. Each participant also completed a detailed questionnaire about general lifestyle. Linear regression univariate analysis and ANCOVA were performed to respectively determine correlations between STL and study parameters or identify statistically significant differences in STL while controlling for age, BMI and other factors. Results:Using a linear regression model, STL is positively correlated with in vitro fertilization success (n = 65, r = 0.37, P = .004) but not with embryo cleavage rates and post-implantation clinical outcomes including gestational age-adjusted birth weight.No associations were observed between STL and sperm count, concentration or progressive motility. We further found that STL did not associate age, BMI, health or lifestyle factors. Discussion: In somatic cells, the rate of telomere shortening is influenced by a number of lifestyle factors such as smoking, diet and occupation. However, little is known about how lifestyle factors affect STL and subsequently reproductive outcome. Out data suggest that STL might have an important role mechanistically for fertilization rate regardless of sperm parameters and lifestyle factors. Conclusion: The results of this study demonstrate that STL is associated with in vitro fertilization rates, but not with semen parameters nor lifestyle factors. Further How to cite this article: Berneau SC, Shackleton J, Nevin C, et al. Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples. Andrology. 2020;8:583-593.

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Effects of Highly Polluted Environment on Sperm Telomere Length: A Pilot Study

Cited by 36 publications

References 27 publications

Impact of Environmental Factors on Male Reproductive Health

Impact of Environmental Factors on Male Reproductive Health

The association of female and male infertility with telomere length (Review)

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

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