Effects of hindbrain melanin-concentrating hormone and neuropeptide Y administration on licking for water, saccharin, and sucrose solutions.

Baird, John-Paul; Rios, Catalina; Loveland, Jasmine Lopez; Beck, J.

doi:10.1016/j.appet.2007.03.026

Cited by 1 publication

(3 citation statements)

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“…These solutions produce systematic differences in licking and intake responses. Water is noncaloric, less palatable, and usually less consumed than either sucrose solution (4,5). The 0.1 M and 1 M sucrose solutions often produce distinct licking microstructure profiles, even though these differences can result in the same volume consumed (4,5,9).…”

Section: Methodsmentioning

confidence: 99%

“…Water is noncaloric, less palatable, and usually less consumed than either sucrose solution (4,5). The 0.1 M and 1 M sucrose solutions often produce distinct licking microstructure profiles, even though these differences can result in the same volume consumed (4,5,9). We have shown that rats exhibit robust licking responses for 1 M sucrose, as indicated by a rapid initial rate of licking, larger mean lick burst sizes/durations (reflecting taste evaluation), and a steep rate of decline in the ingestion rate due to the caloric load, which generates a meal of moderate duration (2).…”

Section: Methodsmentioning

confidence: 99%

“…Rats that did not exhibit at least a 50% increase in blood glucose within 30 min of injection were removed from the study. Correct placement for the 3V cannula was confirmed by a minimum of 5 ml water consumption within 30 min of a 50 ng/5 l 3V cannula injection of ANG II (3)(4)(5).…”

Section: Surgerymentioning

confidence: 99%

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Anatomical dissociation of melanocortin receptor agonist effects on taste- and gut-sensitive feeding processes

Baird

Palacios

LaRiviere

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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Lord J. Anatomical dissociation of melanocortin receptor agonist effects on taste-and gut-sensitive feeding processes. Am J Physiol Regul Integr Comp Physiol 301: R1044 -R1056, 2011. First published July 6, 2011 doi:10.1152/ajpregu.00577.2010.-Injections of the melanocortin 3/4 receptor (MCR) agonist melanotan II (MTII) to a variety of brain structures produces anorexia, suggesting distributed brain MCR control of food intake. We performed a detailed analysis of feeding behavior (licking microstructure analysis) after a range of MTII doses (0.005 nM to 1 nM) was targeted to the forebrain (third ventricle, 3V) or hindbrain (fourth ventricle, 4V) regions. MTII (0.1 nM and 1 nM) delivered to the 3V or 4V significantly reduced 0.8 M sucrose intake. The anorexia was mediated by reductions in the number of licking bursts in the meal, intrameal ingestion rate, and meal duration; these measures have been associated with postingestive feedback inhibition of feeding. Anorexia after 3V but not 4V MTII injection was also associated with a reduced rate of licking in the first minute (initial lick rate) and reduced mean duration of licking bursts; these measures have been associated with taste evaluation. MTII effects on taste evaluation were further explored: In experiment 2, 3V MTII (1 nM) significantly reduced intake of noncaloric 4 mM saccharin and 0.1 M and 1 M sucrose solutions, but not water. The anorexia was again associated with reduced number of licking bursts, ingestion rate, meal duration, initial lick rate, and mean burst duration. In experiments 3 and 4, brief access (20 s) licking responses for sweet sucrose (0.015 M to 0.25 M) and bitter quinine hydrochloride (0.01 mM to 1 mM) solutions were evaluated. Licking responses for sucrose were suppressed, whereas those for quinine solutions were increased after 3V MTII, but not after 4V MTII injections (0.1 nM and 1 nM). The results suggest that multiple brain MCR sites influence sensitivity to visceral feedback, whereas forebrain MCR stimulation is necessary to influence taste responsiveness, possibly through attenuation of the perceived intensity of taste stimuli.MC4R; satiation; satiety; gustatory; food; consumption IT IS WELL ESTABLISHED THAT brain melanocortins influence feeding behavior and energy balance as demonstrated, for example, by natural human and experimental animal mutations of melanocortin receptors (MCRs) that result in hyperphagic and obese phenotypes (16,32). Although the MCRs involved in feeding behavior (particularly MC4R) are expressed in neurons throughout the brain (18,19), the contributions of different anatomical MCR populations to feeding behavior require clarification. A distributed MCR influence on food intake originating from at least partially nonoverlapping MCRexpressing brain structures was first suggested by the observation that anorexic responses to various doses of the MC3/4R agonist melanotan II (MTII) were comparable whether MTII was infused to the forebrain lateral ventricle (LV) or to the hindbrain fourth ventricle (4V) (14)...

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