Effects of Hip Osteoarthritis on Mechanical Stimulation of Trabecular Bone: a Finite Element Study

Marinozzi, Franco; Bini, Fabiano; Paolis, Annalisa De; Luca, Ramona; Marinozzi, Andrea

doi:10.1007/s40846-015-0061-4

Cited by 9 publications

(4 citation statements)

References 50 publications

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“…Bone is a highly dynamic tissue composed of organic (mainly collagen nanofibers) and inorganic apatite minerals disposed of in a hierarchical structure ranging from the nano- to the macro-scale [ 11 , 12 , 13 , 14 ]. Mechanical forces directly influence the remodelling process of bone and, in the case of osteochondral diseases, microstructural changes of the subchondral skeletal tissue [ 15 , 16 , 17 ].…”

Section: Osteochondral Tissue Architecturementioning

confidence: 99%

“…OA is typically characterized by synovial fibrosis, an increase in subchondral cortical bone thickness, a decrease in subchondral trabecular bone mass, and the formation of osteophytes cysts (geodes) [ 1 ]. During OA progression, alterations in the structure of bones may precede severe degeneration of the cartilage tissue [ 1 , 15 , 17 ]. The initial stages of OCDs are routinely treated with physiotherapy and drugs (e.g., glucosamine) that can help to relieve pain and improve the function of tissues with small defects.…”

Section: Osteochondral Diseases and Clinical Managementmentioning

confidence: 99%

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Harnessing Biofabrication Strategies to Re-Surface Osteochondral Defects: Repair, Enhance, and Regenerate

et al. 2023

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Osteochondral tissue (OC) is a complex and multiphasic system comprising cartilage and subchondral bone. The discrete OC architecture is layered with specific zones characterized by different compositions, morphology, collagen orientation, and chondrocyte phenotypes. To date, the treatment of osteochondral defects (OCD) remains a major clinical challenge due to the low self-regenerative capacity of damaged skeletal tissue, as well as the critical lack of functional tissue substitutes. Current clinical approaches fail to fully regenerate damaged OC recapitulating the zonal structure while granting long-term stability. Thus, the development of new biomimetic treatment strategies for the functional repair of OCDs is urgently needed. Here, we review recent developments in the preclinical investigation of novel functional approaches for the resurfacing of skeletal defects. The most recent studies on preclinical augmentation of OCDs and highlights on novel studies for the in vivo replacement of diseased cartilage are presented.

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Section: Osteochondral Tissue Architecturementioning

confidence: 99%

Section: Osteochondral Diseases and Clinical Managementmentioning

confidence: 99%

Harnessing Biofabrication Strategies to Re-Surface Osteochondral Defects: Repair, Enhance, and Regenerate

et al. 2023

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“…Consequently, a detailed understanding of the structure and properties of the complex porous system and its influence on the mechanism of mass transport can contribute to the development of scaffold biomaterials for tissue engineering. The contribution of scaffold biomaterials addresses crucial problems, including changes in bone tissue due to degenerative pathologies, such as osteoporosis and osteoarthritis [4][5].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Tortuosity on Wall Shear Stress of Porous Scaffold

Basri

Prakoso

Abidin

et al. 2023

CFDL

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This study aimed to investigate the effect of morphology on permeability and fluid wall shear stress of porous scaffold. Fluids passing through the scaffold were analyzed using the computational fluid dynamics (CFD) method, and tortuosity was analyzed using the finite-different analysis (FDA) method. Based on the results, the higher the porosity, the higher the permeability. In contrast, by increasing the tortuosity, the permeability decrease. Then, control curvature in the negative Schwarz p design has the potential to increase the permeability, consequently, decrease the specific surface area. Therefore, the design negative Schwarz p was proposed met the requirements for a good implant which the permeability value was in the range of trabecular bone.

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“…A detailed understanding of the structure and properties of this complex porous system and their influence on the mass transport mechanism could give a contribution on crucial issues including alterations of bone tissue due to degenerative pathologies, e.g. osteoporosis 5 , osteoarthritis 6,7 .…”

Section: Introductionmentioning

confidence: 99%

A 3D Model of the Effect of Tortuosity and Constrictivity on the Diffusion in Mineralized Collagen Fibril

Bini

Pica

Marinozzi

et al. 2019

Sci Rep

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Bone tissue is a hierarchically structured material composed at the nanoscale by an organic matrix of collagen type I, apatite mineral and water. We considered an idealized 3D geometrical model of the mineralized collagen fibril in order to analyze the influence of structural factors, i.e. tortuosity, constrictivity, on the water effective diffusivity. The average values of the factors investigated in the diffusivity are computed on 5000 iterations by means of the Montecarlo method. The input parameters of the numerical model are the geometrical dimensions of the apatite mineral, collagen fibrils and their spatial orientation obtained with random extractions from Gaussian probability distribution functions. We analyzed the diffusion phenomenon for concentration gradients parallel to three orthogonal directions (Length, Width and Thickness) and for different scenarios, namely low, intermediate and high apatite volume fraction. For each degree of volume fraction, in the thickness direction, the tortuosity assumes greater values, up to two orders of magnitude, in comparison with the tortuous factors computed in the other directions, highlighting the anisotropy of the nanostructure. Furthermore, it was found that the tortuosity is the dominant parameter which control the effective transport properties within the mineralized collagen fibrils.

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Effects of Hip Osteoarthritis on Mechanical Stimulation of Trabecular Bone: a Finite Element Study

Cited by 9 publications

References 50 publications

Harnessing Biofabrication Strategies to Re-Surface Osteochondral Defects: Repair, Enhance, and Regenerate

Harnessing Biofabrication Strategies to Re-Surface Osteochondral Defects: Repair, Enhance, and Regenerate

The Effect of Tortuosity on Wall Shear Stress of Porous Scaffold

A 3D Model of the Effect of Tortuosity and Constrictivity on the Diffusion in Mineralized Collagen Fibril

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