Effects of hippadine on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Mugabo, Pierre; Philander, Alvenia; Raji, Ismaila; Dietrich, D. L. L.; Green, Ivan R.

doi:10.1016/j.jep.2014.10.011

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…An increase or decrease of the relationship between HR and BP depending on the signalling pathway was reported (Shirasaka et al 2013;Mugabo et al 2014). The absence of a strong correlation between HR and sBP or dBP in L-NAME-treated rats found in our study (Figs 3A and 5A) indicated the absence of a connection between HR and BP signalling pathways in our experimental conditions.…”

Section: Relationships Of Apw Parameters To Sbp and Dbpsupporting

confidence: 62%

Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

Misak

Kristek

Tomášová

et al. 2016

Experimental Physiology

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What is the central question of this study? We wanted to find out whether the relationship between rat arterial pulse waveform (APW) parameters and blood pressure could be described by known mathematical functions and find mathematical parameters for conditions of hypertension resulting from decreased NO bioavailability. What is the main finding and its importance? We found mathematical functions and their parameters that approximate the relationships of 12 APW parameters to systolic and diastolic blood pressure in conditions of decreased NO bioavailability. The results may assign APW parameters to decreased NO bioavailability, which may have predictive or diagnostic value. Information obtained from the arterial pulse waveform (APW) is useful for characterization of the cardiovascular system in particular (patho)physiological conditions. Our goal was to find out whether the relationships between rat APW parameters could be described by simple mathematical functions and to find mathematical parameters for conditions of hypertension resulting from decreased NO bioavailability. Therefore, we explored details of 14 left carotid APW parameters of anaesthetized male Wistar rats and mathematically characterized their relationship to systolic and diastolic blood pressure (BP) in conditions of a gradual reduction in NO bioavailability after administration of l-NAME. The right jugular vein of anaesthetized Wistar rats was cannulated for l-NAME administration. The left carotid artery was cannulated to detect the APW at high resolution. Here, we show the time-dependent parallel changes of 14 APW parameters before and after i.v. administration of l-NAME and present mathematical functions that approximate the relationships of 12 APW parameters to systolic and diastolic BP. Some APW parameters had minor (e.g. heart rate) or biphasic dependence on BP (e.g. relative level of the maximum rate of ventricular pressure decrease (dP/dt )), but all relationships, within a particular range of BP, could be approximated by known regression functions, as a linear function (e.g. pulse BP), exponential decay (e.g. relative level of the maximum rate of ventricular pressure increase (dP/dt )), exponential growth (systolic area), exponential rise to a maximum (relative augmentation index) or sigmoid function (e.g. increase of relative level of dP/dt ). The mathematical functions may assign APW parameters to decreased NO bioavailability. This may have predictive or diagnostic value.

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Section: Relationships Of Apw Parameters To Sbp and Dbpsupporting

confidence: 62%

Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

Misak

Kristek

Tomášová

et al. 2016

Experimental Physiology

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“…The effects of the extract on the tested parameters were on par with those of the known cardioactive sub-stances (except for verapamil in systolic and diastolic pressures), indicating the cardiovascular effects of the plant [62]. Similarly, hippadine (another compound isolated from the plant) at various doses (0.05, 0.10, 0.15, 0.20 mg/kg) has also been reported to lower systolic and diastolic BPs, as well as mean arterial BP, suggesting its antihypertensive [63] and cardiovascular [64] effects.…”

Section: Crinum Macowanii Bakermentioning

confidence: 97%

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension

Balogun

Ashafa

2018

Planta Med

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South Africa contains 9% of the worldʼs higher plants, and despite its rich biodiversity, it has one of the highest prevalence of hypertension in Africa. This review provides information on medicinal plants embraced in South Africa for hypertension management, with the aim of reporting pharmacological information on the indigenous use of these plants as antihypertensives. This review not only focuses on the activity of antihypertensive medicinal plants but also reports some of its phytochemical constituents and other ethnopharmacological and therapeutic properties. Information obtained from scientific and or unpublished databases such as Science Direct, PubMed, SciFinder, JSTOR, Google Scholar, Web of Science, and various books revealed 117 documented antihypertensive plant species from 50 families. Interestingly, Asteraceae topped the list with 16 species, followed by Fabaceae with 8 species; however, only 25% of all plant species have demonstrated antihypertensive effects originating from both in vitro and in vivo studies, lending credence to their folkloric use. Only 11 plant species reportedly possess antihypertensive properties in animal models, with very few species subjected to analytical processes to reveal the identity of their bioactive antihypertensive compounds. In this review, we hope to encourage researchers and global research institutions (universities, agricultural research councils, and medical research councils), particularly those showing an interest in natural products, for the need for concerted efforts to undertake more studies aimed at revealing the untapped potential of these plants. These studies are very important for the development of new pharmaceuticals of natural origin useful for the management of hypertension.

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“…The antibacterial and antifungal activity of A. micrantha extract at high concentrations against human pathogenic bacteria and fungi (Hamid et al 2011)d gangetica extract at a concentration of 100 mg/ml as an effective anthelmintic drug (Jiju et al 2013) demonstrate that a large amount of biomass is required to produce the active extracts. The leaf extract of A. gangetica has been shown to reduce blood pressure and heart rate in hypertensive rats, which is thought to be due to its action on the angiotensin I-converting enzyme, the human angiotensin II receptor, and heart rate (Mugabo and Raji 2013). A. gangetica leaves also exhibit strong antivenom properties, making them helpful in treating snakebites (Enenebeaku et al 2018).…”

Section: Nutritious Local Specialtiesmentioning

confidence: 99%

Asystasia gangetica, beyond its Widespread Distribution Recorded in Two Indonesian Herbaria Since 1863: A Nuisance or A Blessing?

Tanjung,

Nurainas,

Zulaspita

2023

Preprint

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In the world of botanical diversity, some plants manage to find their niche through adaptability and widespread distribution. Asystasia gangetica, one of those versatile species, has established itself in various ecosystems worldwide. Based on specimen collections of the Herbarium Bogoriense and the Herbarium Anda, we investigated the global distribution of this plant by highlighting its characteristics, ecological adaptability, significance, implications, and potential benefits. This study showed that A. gangetica had flourished in Malaysia in 1863, 30 years before it had in Indonesia, refuting the popular belief that it had been introduced to the country in 1876. Furthermore, given the two A. gangetica subspecies differ in phenotype and genotype, we propose that they should be considered distinct species. So, the subsp. gangetica, native to the Indian subcontinent and Southeast Asia and is synonymous with Asystasia coromandeliana, should be named Asystasia gangetica, while the subsp. micrantha, native to Africa and the Arabian Peninsula and is synonymous with Asystasia intrusa, should be named Asystasia micrantha. This study confirmed that A. micrantha is more invasive than A. gangetica. Both plants, however, exhibit advantageous qualities beneficial to humans. As a cover crop, it is useful for conservation efforts. As a food source, it is nutritious for humans and animals. As a bioactive compound source, it can be developed into novel drugs. Its beneficial properties imply that this plant is intended to benefit humans and animals, even though its invasiveness needs to be monitored and regulated. Thus, we believe its advantages outweigh its drawbacks.

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Effects of hippadine on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Cited by 8 publications

References 40 publications

Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension

Asystasia gangetica, beyond its Widespread Distribution Recorded in Two Indonesian Herbaria Since 1863: A Nuisance or A Blessing?

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