Effects of hippocampal kindling on paired-pulse response in CA1 in vitro

Zhao, Dongsheng; Leung, L. Stan

doi:10.1016/0006-8993(91)91457-c

Cited by 60 publications

(35 citation statements)

References 37 publications

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“…way leads to a gradual increase of the GABAergic inhibition in the fascia dentata [7,23,28] whereas in CA1 inhibition decreases [6,7,9,27]. These opposite changes in GABAergic inhibition are accompanied by a bilateral increased binding of GABAA-receptor agonist [3H]muscimol in the fascia dentata [14,18,22] and a decreased binding in CA1 [22].…”

Section: Gabaa R-132mentioning

confidence: 98%

“…In CA1 area, a reduction of the inhibition takes place as evidenced by a reduced paired-pulse inhibition of local evoked field potentials [7,9,27], a decreased sensitivity of the pyramidal neurons for iontophoretically applied GABA [6], and a reduced binding of the GABAA receptor agonist [3H]muscimol [22]. In contrast to the decreased inhibiton in CA1, in the fascia dentata pairedpulse inhibition is strengthened [7,23,28], together with a robust increase in [3H]muscimol binding in this area [14,18,22].…”

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confidence: 99%

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GABAA receptor β1–3 subunit gene expression in the hippocampus of kindled rats

Kamphuis¹,

Rijk²,

Silva³

1994

Neuroscience Letters

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Section: Gabaa R-132mentioning

confidence: 98%

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confidence: 99%

GABAA receptor β1–3 subunit gene expression in the hippocampus of kindled rats

Kamphuis¹,

Rijk²,

Silva³

1994

Neuroscience Letters

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“…changes in GABAAR binding [29,51,62,67,69], in synaptic GABAergic inhibition [7,21,24,70,75,[77][78][79], in sensitivity for iontophoretically applied GABA [19] and in GABAAR mediated C1-uptake in synaptoneurosomes [66]. In this respect, it is of particular interest to compare the opposite changes in CA1-3 area, where a reduced GABAergic inhibition is manifested, with the changes in fascia dentata region where inhibition is strengthened [21,26,66,67,69,79].…”

Section: Relation Of the Observed Mrna Changes And Alterations Of Gabmentioning

confidence: 99%

“…In CA1 area of the hippocampus, experimental evidence has been found in support of this hypothesis; a reduction of inhibitory synaptic transmission takes place in the course of kindling as shown by a reduced pairedpulse inhibition of local evoked field potentials [22,24,26,77,78], a diminished sensitivity of the pyramidal neurons for iontophoretically applied GABA [20] and a reduced binding of the GABA A receptor agonist [3H]muscimol [69] and of benzodiazepines [29,67]. In sharp contrast to the decreased inhibition in CA1, in the fascia dentata paired pulse inhibition is enhanced [7,21,26,70,79], together with an increase in the amplitude of miniature inhibitory postsynaptic currents [53], and a robust increase in both [3H]muscimol and [3H]flunitrazepam binding in this area [51,62,67,69].…”

Section: Introductionmentioning

confidence: 99%

Expression of GABAA receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridization study

Kamphuis

Rijk

Silva

1995

Molecular Brain Research

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Expression of GABA-A receptor subunit in mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridization study. Kamphuis, W.; de Rijk, T.C.; Lopes da Silva, F.H. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Accepted 24 January 1995 AbstractTo investigate the molecular changes underlying kindling epileptogenesis in the rat hippocampus, the expression levels of the genes encoding for 13 different y-aminobutyric acid type-A receptor (GABAAR) subunits were measured in hippocampal principal neurons using in situ hybridization techniques and semi-quantitative analysis of the autoradiograms. Schaffer collateral-commissural pathway kindled rats were investigated at three different stages of kindling acquisition, at 24 h after the last seizure and at long-term (28 days) after termination of kindling stimulations. Changes were distinct for the different subunits in the three analyzed regions (CA1, CA3, fascia dentata) and also different for the various kindling stages. In all hippocampal areas at the early phases of kindling epileptogenesis, before the appearance of generalized seizures, an increase was found of those transcripts that constituted the majority of the expressed variants in control animals (al, a2, a4, /31, /32, /33, y2/y2L mRNA). In these stages, the increased levels of different variants in the granular neurons of the fascia dentata were more pronounced when compared to the pattern of changes in pyramidal cells of CA1 and CA3. In fully kindled animals, the expression levels of several subunits returned to control levels, whereas/33 and y2/y2L mRNA expression was still significantly enhanced in all areas. At long-term, few changes were encountered. The long-splice variant of 3,2 was decreased within pyramidal and granular neurons while the total level of y2 mRNA was not different from controls. The increased GABAAR subunit expression in the fascia dentata may underly the reported increased GABAAR ligand binding and the increased GABA mediated inhibition. However, the decreased GABAAR binding and the attenuation of GABAergic inhibition in CA1, could not be explained by a decrement of receptor subunit expression.

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“…The acquisition of the kindled state by Schaffer collateral/commissural fibre pathway stimulation is accompanied by a substantial increase in excitability of the local hippocampal CA1 network which is manifested by a re-duction of paired-pulse inhibition of local evoked field potentials [13,36] and a diminished sensitivity of the pyramidal neurons for the inhibitory action of y-aminobutyric acid (GABA) [11]. However, the reduction of GABAergic inhibition is associated with only a small reduction in the binding of GABAA-receptor ligands [32], and is even paralleled by an unexpected increase of the expression levels of genes that encode for the subunits of the GABAA-receptor [9].…”

Section: Introductionmentioning

confidence: 99%

Isozyme specific changes in the expression of protein kinase C isozyme (α-ζ) genes in the hippocampus of rats induced by kindling epileptogenesis

1995

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Isozyme specific changes in the expression of protein kinase C isozyme (alpha -) genes in the hippocampus of rats induced by kindling epileptogenesis Kamphuis, W.; Hendriksen, E.; Lopes da Silva, F.H. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. AbstractThe transcript levels of the protein kinase C (PKC) isoform genes during the development of a kindled epileptogenic focus, elicited by stimulation of Schaffer collateral/commissural fibres in the CA1 area of the rat hippocampus, were compared with the expression levels in control animals using a semi-quantitative in situ hybridization approach. In the hippocampus of control animals, the levels of PKC-o~-s r transcripts showed a gene-specific expression pattern and significant differences in expression level were observed between the neurons of CA1, CA3 and fascia dentata. In the early stages of kindling epileptogenesis, i.e. following 6 and 14 afterdischarges, specific changes in the expression levels of PKC-/3, -e, and -5 but not of PKC-a, -Y, and -6 were found. PKC-/3 expression was decreased in CA1, while the PKC-e and _r specific hybridization signals were increased in CAI, CA3 and fascia dentata. In fully kindled animals, that had experienced 10 generalized seizures, most expression levels tended to return to control values. One month after the last seizure no significant alterations were encountered. These results indicate an involvement of specific PKC-isoform gene expression in the induction of an epileptogenic focus, but not in the maintenance of the long-lasting kindled state.

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Effects of hippocampal kindling on paired-pulse response in CA1 in vitro

Cited by 60 publications

References 37 publications

GABAA receptor β1–3 subunit gene expression in the hippocampus of kindled rats

GABAA receptor β1–3 subunit gene expression in the hippocampus of kindled rats

Expression of GABAA receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridization study

Isozyme specific changes in the expression of protein kinase C isozyme (α-ζ) genes in the hippocampus of rats induced by kindling epileptogenesis

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