Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia

Tsumuraya, Tomoyuki; Ishikawa, Chie; Machijima, Yoshiaki; Nakachi, Sawako; Senba, Masachika; Tanaka, Junichi; Mori, Nozomu

doi:10.1016/j.bcp.2010.12.025

Cited by 75 publications

(57 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Sun et al [27] have demonstrated that it blocks eIF4A1 helicase activity by locking it into a 'closed' conformation. Hippuristanol has not only been shown to suppress tumour growth in a mouse model of Tcell leukaemia, but also chemosensitizes Myc-driven tumours to DNA damaging agents in the Eμ-Myc mouse model [28,29].…”

Section: Hippuristanolmentioning

confidence: 99%

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

Raza

Waldron

Quesne

2015

Biochemical Society Transactions

View full text Add to dashboard Cite

The malignant phenotype is largely the consequence of dysregulated gene expression. Transformed cells depend upon not just a global increase in protein synthesis but an altered translational landscape in which pro-oncogenic mRNAs are translationally up-regulated. Such mRNAs have been shown to possess longer and more structured 5'-UTRs requiring high levels of eukaryotic initiation factor 4A (eIF4A) helicase activity for efficient translation. As such there is a developing focus on targeting eIF4A as a cancer therapy. In order for such treatments to be successful, we must develop a detailed understanding of the mechanisms which make specific mRNAs more dependent on eIF4A activity than others. It is also crucial to fully characterize the potentially distinct roles of eIF4A1 and eIF4A2, which until recently were thought to be functionally interchangeable. This review will highlight the recent advances made in this field that address these issues.

show abstract

Section: Hippuristanolmentioning

confidence: 99%

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

Raza

Waldron

Quesne

2015

Biochemical Society Transactions

View full text Add to dashboard Cite

show abstract

“…A pre-clinical study assessing the potential of hippuristanol as a therapeutic agent against adult T-cell leukemia (ATL) found it to arrest cells in G 1 [117]. Hippuristanol also induced apoptosis of ATL cells but not peripheral blood mononuclear cells [117].…”

Section: Hippuristanolmentioning

confidence: 99%

Targeting the eIF4A RNA helicase as an anti-neoplastic approach

Chu

Pelletier

2015

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

View full text Add to dashboard Cite

“…These mice lack mature B-and T-cells allowing xenogeneic engraftment. Different ATLL cell lines have been transplanted into SCID mice (Tables S1 and 3) often to test therapeutic strategies [69][70][71][72]. Engraftment and tumor growth even occurred in formerly (in vitro) IL2-dependent lines with the cytokine source becoming the murine host [73].…”

Section: Xenograft Mouse Models For Mtclmentioning

confidence: 99%