Effects of Homologous and Heterologous Neuraminidase Vaccines in Chickens Against H5N1 Highly Pathogenic Avian Influenza

Lee, Y. J.; Sung, Haan Woo; Choi, Jun‐Gu; Lee, E. K.; Jeong, Ok-Mi; Kwon, Yong-Kuk; Kwon, Jun-Hun; Song, Chanchan; Kim, J. H.

doi:10.1637/1933-5334(2007)2[e66:eohahn]2.0.co;2

Cited by 4 publications

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“…have shown that viral shedding was reduced and transmission was prevented with HI titres >4 log 2 [16]; and Lee et al . have shown that no shedding was observed for HI titres >5 log 2 [49]. Therefore experimental data confirm the threshold value of HI titres >4 log 2 , as defined by the OIE International Manual, to assess vaccine efficacy in terms of protection of the vaccinated animals [2].…”

Section: Avian Vaccinessupporting

confidence: 56%

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Avian influenza vaccines: a practical review in relation to their application in the field with a focus on the Asian experience

Peyre

Guo²,

Desvaux

et al. 2008

Epidemiol. Infect.

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Vaccination can be a useful tool for the control of avian influenza (AI) outbreaks, but its use is prohibited in most of the countries worldwide because of its interference with AI surveillance tests and its negative impact on poultry trade. AI vaccines currently in use in the field increase host resistance to the disease but have a limited impact on the virus transmission. To control or eradicate the disease, a carefully conceived vaccination strategy must be accompanied by strict biosecurity measures. Some countries have authorized vaccination under special circumstances with contradictory results, from control and disease eradication (Italy) to endemicity and antigenic drift of the viral strain (Mexico). Extensive vaccination programmes are ongoing in South East Asia to control the H5N1 epidemic. This review provides practical information on the available AI vaccines and associated diagnostic tests, the vaccination strategies applied in Asia and their impact on the disease epidemiology.

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Section: Avian Vaccinessupporting

confidence: 56%

“…Lee et al . have also demonstrated that fourfold more HI titres were required to protect vaccinated animals against challenge with heterologous virus [49]. Moreover, Liu et al .…”

Section: Avian Vaccinesmentioning

confidence: 99%

Avian influenza vaccines: a practical review in relation to their application in the field with a focus on the Asian experience

Peyre

Guo²,

Desvaux

et al. 2008

Epidemiol. Infect.

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“…Vaccination with the heterologous neuraminidase (N2) could be a useful tool for the control of H5N2 epidemic in poultry (Lee et. al., 2007).…”

Section: Resultsmentioning

confidence: 99%

Study of Incorporation Deae Dextran During Production of Local Avian Influenza (Ai) Inactivated Vaccine

Wanis

Tolba

2011

Egyptian Journal of Agricultural Research

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Two experiments have been conducted to study incorporation of di-ethyl amino ethyl dextran (DEAE Dextran) during production of avian influenza (AI) inactivated vaccine.The first was planned to study addition of DEAE Dextran with different concentrations (25g, 50g and 100g/0.1ml) to the virus inoculum seed before egg inoculation. Obtained results revealed selection of 25g DEAE Dextran/0.1 ml that resulted in increasing haemagglutinating activity (HA) with 2 log and virus titre (EID 50 ) with 3.2.In the second experiment, the same concentrations were added and tested separately during vaccine preparation with two different adjuvants. Serum of vaccinated chickens with the vaccine to which 100 g DEAE Dextran / 0.5 ml was added, developed satisfactory raise in antibody level in comparing to positive control groups which received the vaccine without any additives.

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“…There is much evidence of the direct relationship between HI titers and protection after inactivated vaccines. Kumar et al (2007) and van der Goot et al (2005) have shown that viral shedding was reduced and transmission was prevented with HI titers>4 log2; (Kumar et al, 2007;Van der Goot et al, 2005;Lee et al, 2007) have shown that no shedding was observed for HI titers>5 log2 (Lee et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Comparative Assessment of Seroconversion in Poultry Vaccinated with Two Avian Influenza Vaccines

Astemirov¹,

Mamadaliyev²,

Perfiliyeva³

et al. 2022

American Journal of Animal and Veterinary Sciences

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From August to December 2020, a new outbreak of H5 avian influenza caused another serious animal health emergency in Kazakhstan, leading to the deaths or culling of more than 500 000 chickens. This outbreak renewed interest in developing prevention strategies for this re-emerging infection. In this study, we evaluated poultry seroconversion levels after two H5 vaccines. Regardless of age, productivity, and scheme of vaccination Super Nick layers (a total of 368 heads) received a single dose of an inactivated whole H5 vaccine or a baculovirus-derived H5 vaccine, respectively. We assessed the seroconversion by Hemagglutination Inhibition (HI) and Enzyme-Linked Immunosorbent (ELISA) assays. Cloacal and tracheal swabs were tested for Influenza A Virus (AIV) by realtime PCR to monitor the field AIV circulation. The analysis of 368 serum samples showed that the inactivated vaccine provided a significantly higher humoral immune response when compared to the baculovirus-derived vaccine as evaluated by both ELISA and HI in 30, 60, and 120 Days Post-Vaccination (DPV). Thus, our study demonstrates that under farm conditions classical Inactivated Avian Influenza (AIV) vaccine induces a higher seroconversion level against the H5N1 virus predicting better protection against field infection, than a baculovirus-derived H5 vaccine.

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Effects of Homologous and Heterologous Neuraminidase Vaccines in Chickens Against H5N1 Highly Pathogenic Avian Influenza

Cited by 4 publications

References 0 publications

Avian influenza vaccines: a practical review in relation to their application in the field with a focus on the Asian experience

Avian influenza vaccines: a practical review in relation to their application in the field with a focus on the Asian experience

Study of Incorporation Deae Dextran During Production of Local Avian Influenza (Ai) Inactivated Vaccine

Comparative Assessment of Seroconversion in Poultry Vaccinated with Two Avian Influenza Vaccines

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