Effects of hormonal contraceptives and pregnancy on serum protein pattern

Gleichmann, W.; Bachmann, G. W.; Dengler, H. J.; Dudeck, J

doi:10.1007/bf00567007

Cited by 32 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…␤2GPI levels are also significantly reduced in pregnant women at 36 weeks of pregnancy when compared to those found in non-pregnant women or in eight-week pregnant women. This is in line with previous reports, 45,64 although this reduction does not reach 50% as reported by Ganrot. 65 It is possible that the decrease of ␤2GPI levels is at least partly explained by the dilution or redistribution of plasma proteins, which may be found in pregnant women.…”

Section: Discussionsupporting

confidence: 94%

Circulating levels of β2-glycoprotein I in thrombotic disorders and in inflammation

Lin

Murphy

White

et al. 2006

Lupus

View full text Add to dashboard Cite

Beta2-glycoprotein I (beta2GPI) is a plasma protein suspected to have a role in inhibition of thrombosis. This suspicion is reinforced by the observation that beta2GPI is the major target for autoantibodies in the antiphospholipid syndrome. However, little is known about its circulating levels in common thrombotic diseases or inflammation. We measured beta2GPI levels in 344 healthy controls, 58 normal pregnancies, 102 patients with non-haemorrhagic stroke, 121 patients with acute coronary syndrome and 200 patients with elevated C-reactive protein (CRP). In healthy individuals, we found a strong positive correlation between age and beta2GPI concentration (r = 0.274, P < 0.001) and that beta2GPI levels fall significantly after the eighth week of pregnancy (P = 0.002). We also found significantly reduced levels of beta2GPI in patients with stroke and in elderly patients with myocardial syndrome (P = 0.013 and 0.043). However, in neither group did beta2GPI levels change in the following six months, suggesting that the reduced levels were not a transient post-event phenomenon. In patients with inflammation, beta2GPI levels showed a significant negative correlation with CRP (r = -0.284, P < 0.001) and positively correlated with albumin and transferrin (r = 0.372 and 0.453, respectively with P < 0.001 for both). Furthermore, the largest reduction in beta2GPI levels occurred in patients with the highest CRP values (P < 0.001).

show abstract

Section: Discussionsupporting

confidence: 94%

Circulating levels of β2-glycoprotein I in thrombotic disorders and in inflammation

Lin

Murphy

White

et al. 2006

Lupus

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that the AAG concentration in plasma is the major determinant of lignocaine binding. It has been reported that oestrogen containing oral contraceptives reduce the circulating plasma AAG concentration by as much as 35% (Laurell, Kullander & Thorell, 1969 Bachmann, Dengler & Dudeck, 1973). It is therefore not surprising that the mean free percentage of lignocaine in the females taking oral contraceptives was 11% higher than in contraceptive free females.…”

Section: Discussionmentioning

confidence: 99%

Sex‐related differences in the plasma protein binding of lignocaine and diazepam.

Routledge¹,

Stargel²,

Kitchell³

et al. 1981

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 The percentage of lignocaine free in the plasma of ten females receiving oral contraceptive medication was significantly greater than in 17 males of similar age (18-42 years). 2 In the same subjects the percentage of diazepam free in plasma was significantly greater in the contraceptive treated group than in 11 contraceptive-free females and significantly greater in contraceptive-free females than in males.3 The differences in lignocaine binding were almost completely attributable to changes in a,-acid glycoprotein concentration, which is reduced by oestrogens. The binding of diazepam was significantly related to albumin, a,-acid glycoprotein and non-esterified fatty acid concentrations which together were related to 55% of the variation in the binding of this basic compound.

show abstract

“…In contrast, there was a significant, albeit nonenantioselective diminution of the binding of propranolol after treatment with the synthetic oestrogen ethinyl oestradiol. The administration of ethinyl oestradiol, with or without a progestin, has been shown to decrease plasma concentrations of AGP in some studies [15][16][17][18] but not in others [19]. There are few studies reporting both plasma drug binding and AGP concentrations during oral contraceptive use and the results have not been consistent [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers.

Walle

Fagan

Topmiller

et al. 1994

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 Plasma binding of tritium-labelled racemic propranolol (P) was measured by equilibrium dialysis. The unbound enantiomers were separated by h.p.l.c after chiral derivatization. The binding of (-)-P was higher than that of (+)-P. 2 Contrary to previous suggestions, a sex difference in the plasma binding of the P enantiomers (9 young women, 12 young men) was not observed. The unbound percentage of (-)-P was 9.2 ± 1.8 (mean ± s.d.) in women vs 9.1 ± 1.7 in men; for (+)-P it was 10.8 ± 1.8 vs 10.8 ± 2.1. 3 In the nine women, the binding did not change with fluctuating plasma oestradiol concentrations during the menstrual cycle. Testosterone cypionate doubled the circulating concentrations of testosterone in eight men but had no effect on P binding. 4 Ethinyl oestradiol (50 ,ug day-') alone or together with norethindrone (OCD) in eight of the women produced an increase in the unbound percentage of both (-)-P (11.4 + 2.6 vs 9.5 ± 1.6 for control; P < 0.001) and (+)-P (13.2 ± 2.5 vs 11.2 ± 1.5 for control; P < 0.001). This was due to a decrease in the plasma concentrations of ao-acid glycoprotein from 0.54 ± 0.11 mg ml-' in control to 0.37 ± 0.08 mg ml-' (P < 0.001) during ethinyl oestradiol treatment. 5 Enantioselectivity in the unbound fraction of P increased with increasing total binding from a (-)/(+)-ratio of 0.93 at 84% binding to a (-)/(+)-ratio of 0.78 at 94% binding (P < 0.001).

show abstract

Effects of hormonal contraceptives and pregnancy on serum protein pattern

Cited by 32 publications

References 36 publications

Circulating levels of β2-glycoprotein I in thrombotic disorders and in inflammation

Circulating levels of β2-glycoprotein I in thrombotic disorders and in inflammation

Sex‐related differences in the plasma protein binding of lignocaine and diazepam.

The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers.

Contact Info

Product

Resources

About