Effects of Hormone Replacement Therapy on Sarcopenia: Is It Real?

Abstract

See the Reply by https://doi.org/10.1111/jgs.15805.

Reply to Effects of Hormone Replacement Therapy on Sarcopenia: Is It Real?

“…Bea and colleagues found that lean body mass loss was lower in the HRT intervention arms compared to controls at year 3 follow-up; however, the association reversed between years 3 and 6 of follow-up, suggesting no long-term benefit to HRT use on lean body mass. 3 Additionally, this study found no significant association between HRT use and falls. Another WHI analysis on sarcopenia compared women currently using HRT to nonusers in a sensitivity analysis and found no significant difference in the association with risk of fractures across groups.…”

“…2 Another study by Sanders et al showed that the main concern in oral administration of vitamin D replacement is an increased risk of falls and fractures among the older population. 3 In this study the mean baseline vitamin D levels were higher than 20 ng/mL. Therefore, we would like to ask if falls were specifically evaluated in this study.…”

“…In summary, we thank Unsal and colleagues for their feedback. We agree with the authors that future large cohorts should collect strength measures to help develop a universal definition of sarcopenia.…”

“…We thank Unsal and colleagues for their interest in our research on sarcopenic obesity and falls in postmenopausal women and for the opportunity for constructive discourse …”

“…With respect to the second main point from Unsal and colleagues, we are aware that recent sarcopenia consensus definitions include a measure of muscle strength along with lean mass. As elaborated in our limitations section, although a small subset of the WHI cohort completed measures of physical function, there is limited overlap with those who completed dual‐energy X‐ray absorptiometry (DXA) scans.…”