Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women

Dedeoğlu, Emine Nihan; Erenus, Mithat; Yörük, Pınar

doi:10.1016/j.fertnstert.2007.11.061

Cited by 19 publications

(20 citation statements)

References 54 publications

(81 reference statements)

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“…Diseases such as obesity and metabolic syndrome are associated with chronically high leptin levels (Brennan and Mantzoros, 2006); conversely, following a low-fat diet decreases circulating leptin (Dubuc et al, 1998). Both pre- and post-menopausal women have higher leptin levels than men, which may be due to endogenous estrogen levels or adipose tissue distribution (Dedeoglu et al, 2009; Rosenbaum et al, 1996; Saad et al, 1997). In premenopausal women, leptin levels correlate with plasma levels of estrogen; this correlation disappears after menopause, when it is confounded by a rise in obesity (Hong et al, 2007).…”

Section: Estrogen Regulation Of Whole-body Metabolismmentioning

confidence: 99%

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Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg

Yao

Brinton

2014

Frontiers in Neuroendocrinology

407

299

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Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen protects against adiposity, insulin resistance, and type II diabetes, and regulates energy intake and expenditure. During menopause, decline in circulating estrogen is coincident with decline in brain bioenergetics and shift towards a metabolically compromised phenotype. Compensatory bioenergetic adaptations, or lack thereof, to estrogen loss could determine risk of late-onset Alzheimer’s disease. Estrogen coordinates brain and body metabolism, such that peripheral metabolic state can indicate bioenergetic status of the brain. By generating biomarker profiles that encompass peripheral metabolic changes occurring with menopause, individual risk profiles for decreased brain bioenergetics and cognitive decline can be created. Biomarker profiles could identify women at risk while also serving as indicators of efficacy of hormone therapy or other preventative interventions.

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Section: Estrogen Regulation Of Whole-body Metabolismmentioning

confidence: 99%

“…There is no consensus as to whether leptin levels increase, stay the same, or even decrease after menopause, and each of these has been reported by multiple clinical studies (reviewed by (Dedeoglu et al, 2009)). This is likely due to age differences between the populations studied in each trial.…”

Section: Estrogen Regulation Of Whole-body Metabolismmentioning

confidence: 99%

Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg

Yao

Brinton

2014

Frontiers in Neuroendocrinology

407

299

View full text Add to dashboard Cite

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“…Vaginal atrophy also was reflected in decreased vaginal weights (Balakrishnan et al 2014). Tibolone extensively used by Effect of placenta on menopausal symptoms postmenopausal women for the treatment of climacteric symptoms and prevention of osteoporosis has a suppressive effect on body weight (Dedeoglu et al 2009). Phytoestrogen-rich diet alleviates menopausal symptoms, increasing serum E 2 (Albertazzi et al 1999) and vaginal cell maturation, and preventing vaginal atrophy in postmenopausal women (Chiechi et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of porcine placenta in a menopausal ovariectomized mouse

et al. 2015

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Menopause is a significant physiological phase that occurs as women's ovaries stop producing ovum and the production of estrogen declines. Human placenta and some amino acids are known to improve menopausal symptoms. In this study, we investigated that porcine placenta extract (PPE) and arginine (Arg), a main amino acid of PPE, would have estrogenic activities in ovariectomized (OVX) mice as a menopause mouse model, human breast cancer cell line (MCF-7) cells, and human osteoblast cell line (MG-63) cells. PPE or Arg significantly inhibited the body weight and increased the vagina weight compared to the OVX mice. PPE or Arg ameliorated the vaginal atrophy in the OVX mice. The levels of 17b-estradiol and the activities of alkaline phosphatase (ALP) were significantly increased by PPE or Arg in the serum of OVX mice. Trabecular bone parameters such as bone mineral density and porosity were also improved by PPE or Arg in the OVX mice. In the MCF-7 and MG-63 cells, PPE or Arg significantly increased the cell proliferation, estrogen receptor b mRNA expression, and estrogen-response elements luciferase activity. Finally, PPE or Arg increased the activations of ALP and extracellular signalregulated kinase 1/2 in the MG-63 cells. These results indicate that PPE or Arg would have estrogenic and osteoblastic activity. Therefore, PPE or Arg may be useful as new pharmacological tools for treating menopausal symptoms including osteoporosis. Free Korean abstract: A Korean translation of this abstract is freely available at

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“…Em contrapartida, outros estudos têm atribuído discreta redução no ganho ponderal 22,23 . Pesquisas atribuem o aumento do nível sérico de leptina (normalmente diminuído do período da pós-menopausa) ao uso de TH, o que contribui para a manutenção do peso e distribuição da gordura corporal 24 . Outros estudos descrevem interferência do uso isolado de estrogênio com ganho de peso mais sensível do que nos casos da sua utilização associada com progestativos 10 .…”

Section: Discussionunclassified

Sintomas climatéricos e estado nutricional de mulheres na pós-menopausa usuárias e não usuárias de terapia hormonal

Gravena¹,

Rocha²,

Romeiro³

et al. 2013

Rev. Bras. Ginecol. Obstet.

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ResumoOBJETIVO: Analisar os sintomas climatéricos e estado nutricional em mulheres na pós-menopausa, usuárias e não usuárias de terapia hormonal (TH). MÉTODOS: Estudo analítico, exploratório, tipo inquérito populacional domiciliar, realizado na área urbana do município de Maringá, Paraná, incluindo 456 mulheres com idade entre 45 e 69 anos, no período pós-menopausa. A coleta teve como base de referência os setores censitários urbanizados (368) do município, de acordo com o Censo Demográfico Brasileiro. Foi utilizada amostra aleatória simples proporcional às mulheres residentes em cada setor censitário e, por meio de visita domiciliar, aplicou-se um questionário e verificaramse as medidas antropométricas e pressão arterial. Para avaliação dos sintomas climatéricos, foi utilizado o Índice Menopausal de Blatt e Kupperman. A variável desfecho foi o uso de TH. RESULTADOS: A média de idade foi de 58,7 anos. O excesso de peso esteve presente em 72,6% das mulheres e a obesidade abdominal em 81,4% delas. Sintomas climatéricos de intensidade leve foram evidenciados em 69,5% das mulheres. Apenas 18,4% das mulheres faziam uso de TH e eram, na sua maioria, brancas, não fumantes, sem comorbidades e sem companheiro. Usuárias de TH apresentaram menor frequência de excesso de peso e obesidade abdominal e tiveram menor prevalência de sintomas climatéricos de intensidade severa. CONCLUSÃO: O excesso de peso e a obesidade abdominal foram prevalentes na amostra estudada. Embora em menor número, as usuárias de TH apresentaram uma frequência menor de excesso de peso e sintomas climatéricos leves e intensos na pós-menopausa. Abstract PURPOSE:To analyze the climacteric symptoms, nutritional status and distribution of abdominal fat in postmenopausal women using or not hormone therapy. METHODS: exploratory analytical study of the population survey type in the urban area of Maringa, Parana, conducted on 456 postmenopausal women aged 45 to 69 years. Data collection was based on the urbanized census sector (368) of the municipality, according to the Brazilian Demographic Census. A simple random sample proportional to women residing in each census sector was used, and a questionnaire was applied during a home visit, when anthropometric measurements were performed and blood pressure was determined. The Blatt and Kupperman Menopausal Index was used for the evaluation of climacteric symptoms. The outcome variable was the use of hormone therapy. RESULTS: Mean subject age was 58.7 years. Overweight was present in 72.6% of the women and abdominal obesity in 81.4% of them. Mild climacteric symptoms were observed in 69.5% of the women. Only 18.4% of the women studied were using hormone therapy and they were white, non-smokers, had no comorbidities, and had a partner. Users of hormone therapy had a lower frequency of overweight and obesity and had a lower prevalence of severe climacteric symptoms. CONCLUSION: Overweight and obesity were prevalent in this sample. Although fewer in number, the hormone therapy users had a lower frequency of overweight an...

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Effects of hormone therapy and tibolone on body composition and serum leptin levels in postmenopausal women

Cited by 19 publications

References 54 publications

Estrogen: A master regulator of bioenergetic systems in the brain and body

Estrogen: A master regulator of bioenergetic systems in the brain and body

Protective effect of porcine placenta in a menopausal ovariectomized mouse

Sintomas climatéricos e estado nutricional de mulheres na pós-menopausa usuárias e não usuárias de terapia hormonal

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