Effects of "hormonogen" forms of neurohypophysial peptides in hemorrhagic shock in dogs

Cort, J. H.; Jeanjean, Michel; Thomson, A E; Nickerson, Mark

doi:10.1152/ajplegacy.1968.214.3.455

Cited by 23 publications

(7 citation statements)

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“…TGLVP (Ferring Ltd, Malmö, Sweden) [Kasafirek et al, 1966;Cort et al, 1968] was used because of its long duration of action and hemodynamic properties similar to those of lysine-vasopressin (LVP) [Cort et al, 1975]. 253 male and female NMRI mice, body weight 25-27 g, were burned and divid ed into three groups.…”

Section: Methodsmentioning

confidence: 99%

Survival in Burned Mice after Treatment with Triglycylvasopressin

Wetterlin¹,

Ericsson²,

Aronsen³

1976

Eur Surg Res

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Standardized skin burn injuries were induced in 253 NMRI mice. The burned surface corresponded to 15% of the total surface of a 25-gram mouse. All animals received intraperitoneal injection of an isotonic saline solution in a dose of 20% of body weight/day for 5 days. The material was divided into three groups, i.e. group A (controls) which received no further treatment, groups B and C which, in addition, received triglycylvasopressin (a vasopressin with prolonged effect) 100 and 200 µg/kg body weight, respectively, subcutaneously twice a day. The highest survival rate was registered in group B (61%), while the controls had a survival of 36%.

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Section: Methodsmentioning

confidence: 99%

Survival in Burned Mice after Treatment with Triglycylvasopressin

Wetterlin¹,

Ericsson²,

Aronsen³

1976

Eur Surg Res

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“…This substance was reported by Cort et al (1968) to have a pressor effect of several hours duration, while lysinevasopressin (LVP) has a response half-life of only 5--10 minutes. The haemodynamic effects seem to be equivalent to those of LVP.…”

Section: Ratsmentioning

confidence: 99%

Haemostatic effect of triglycylvasopressin on bleeding from gastric mucosal lesions in the rat

et al. 1978

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“…organ systems varies, the restriction in blood flow being greatest in skeletal muscle, skin and splanchnic circulation, whereas the blood supply to the brain and the kidneys seems little affected (Nakano, 1974;Reid & Schwartz, 1984). Certain effects of the drug have been proven beneficial in haemorrhagic shock in dogs (Cort et al, 1968). The constricting effect on splanchnic arterioles has been utilized to limit loss of blood in patients with bleeding oesophageal varices (Vosmik et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

“…The present study is concerned with certain cardiovascular effects of a synthetic analogue to vasopressin, triglycyl-lysine-vasopressin (TGLVP or Glypressin@, Ferring) which after conversion to LVP exerts powerful constriction of resistance vessels (Cort et al, 1968;Blei et al, 1980;Forsling ef al., 1980). Important determinants of the cardiovascular tolerance to orthostasis are total peripheral resistance to blood flow and cardiac output (Gauer & Thron, 1965).…”

Section: Introductionmentioning

confidence: 99%

Effects of triglycyl‐lysine‐vasopressin on cardiovascular responses to orthostatic stress

Baer

Eiken

Balldin

1987

Clinical Physiology

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The influence of triglycyl-lysine-vasopressin (TGLVP) on cardiovascular responses to orthostatic stress was studied. Arterial pressures, heart rate (HR) and stroke volume (SV) were measured in eight healthy males subjected to 20 min 70 degrees head-up tilt. On different days they received either 0.01 mg/kg b.w. of TGLVP or a corresponding volume of 0.9% saline i.v. after 15 min supine rest. After the drug injection, in supine subjects, HR had decreased from 58 to 50 beats min-1, total peripheral resistance (TPR) was elevated by 29%, systolic (SAP) and diastolic pressure (DAP) had increased by 7 and 8 mmHg, respectively. During tilt, values for HR and SAP were similar with and without TGLVP whereas DAP and MAP were elevated 8 and 7 mmHg, respectively, by the drug. 4-8 min into the tilt, TGLVP caused an 8% sustained curtailment of SV. Both with and without the drug TPR increased by about 30% in response to head-up tilt. Thus, the marked peripheral arteriolar constriction after vasopressin in the supine position was not affected by head-up tilt. Tilting also abolished the drug-induced elevation in SAP, most likely explained by the reduction in SV. Although TPR was markedly increased by TGLVP during head-up tilt, reflected in the behaviour of DAP, the response of SV speaks against any beneficial effect of this drug on orthostatic tolerance in healthy subjects.

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Effects of "hormonogen" forms of neurohypophysial peptides in hemorrhagic shock in dogs

Cited by 23 publications

References 0 publications

Survival in Burned Mice after Treatment with Triglycylvasopressin

Survival in Burned Mice after Treatment with Triglycylvasopressin

Haemostatic effect of triglycylvasopressin on bleeding from gastric mucosal lesions in the rat

Effects of triglycyl‐lysine‐vasopressin on cardiovascular responses to orthostatic stress

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