Effects of household environmental exposure and ventilation in association with adverse birth outcomes: A prospective cohort study in rural China

Pan, Dongxiang; Liu, Shun; Huang, Dongping; Zeng, Xianmin; Zhang, Yuanxiao; Pang, Qiang; Wu, Haiming; Tan, Hui; Liang, Jun; Sheng, Yonghong; Qiu, Xiaoqiang

doi:10.1016/j.scitotenv.2022.153519

Cited by 15 publications

(10 citation statements)

References 50 publications

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“…Regarding household air pollution, a retrospective study found that paternal smoking exposure and home renovation exposure during pregnancy was significantly associated with PTB in boys but not in girls, while pet-keeping during gestation was significantly associated with LBW and term LBW in girls but not in boys [ 16 ]. In addition, a recent prospective birth cohort study indicated that the household use of wood as a primary cooking fuel was associated with SGA only among girls [ 33 ].These findings all suggest that child sex might moderate the associations between prenatal environmental exposure and pregnancy outcomes. Some studies have indicated that different placental lesions and adaptations between male and female infants might be the potential biological mechanisms underlying theses sex differences in birth outcomes [ 31 , 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since prior studies have reported that the different sex of the fetus might have different responses to environmental exposures [ 16 , 31 , 32 , 33 ], we conducted a stratification analysis to test whether our targeted associations varied by child sex. We also conducted a sensitivity analysis to assess whether above associations were robust among 61,226 participants with complete data in all the selected covariates.…”

Section: Methodsmentioning

confidence: 99%

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First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

Liu

Strodl

et al. 2022

IJERPH

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Mosquito coils are efficient mosquito repellents and mosquito coil smoke (MCS) contributes to indoor air pollution. However, no prior population-based study has investigated whether prenatal MCS exposure is a risk factor for preterm birth (PTB) and whether exposure to MCS in different trimesters of pregnancy is associated with different levels of risk. The sample involved 66,503 mother–child dyads. Logistic regression models were used to examine the relationships between prenatal MCS exposure during different trimesters of pregnancy and PTB. We found that prenatal MCS exposure was associated with a greater likelihood of PTB (OR = 1.12, 95%CI: 1.05–1.20). The prenatal MCS exposure during the first trimester was associated with 1.17 (95%CI: 1.09–1.25) times the odds of being PTB, which was higher than exposure during the second trimester (OR = 1.11, 95%CI: 1.03–1.19) and during the third trimester (OR = 1.08, 95%CI: 1.01–1.16). In the stratified analysis, prenatal MCS exposure significantly increased PTB risk among girls but not among boys. Our results indicated that maternal MCS exposure during pregnancy was associated with PTB and that the first trimester might be the sensitive period. In light of these findings, public health interventions are needed to reduce prenatal exposure to MCS, particularly during the first trimester of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

Liu

Strodl

et al. 2022

IJERPH

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“…However, there remains inadequate epidemiologic evidence linking perinatal exposure to air pollution with adverse birth outcomes and growth and development during childhood, especially based on pregnancy cohorts from low-income and middle-income countries (LMICs). In last 10 years, only eight cohort studies in LMICs investigated the effect of hazardous air pollutants from unclean cooking fuels on infant health outcomes 11 13–21. Moreover, in LMICs detailed exposure assessments are typically unavailable, which limits the capacity to produce robust evidence on the health effects of indoor air pollution 22…”

Section: Introductionmentioning

confidence: 99%

Cohort profile: Bangladesh Cook Stove Pregnancy Cohort Study (CSPCS)

et al. 2023

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PurposeThe Cook Stove Pregnancy Cohort Study (CSPCS) was designed to assess the effects of biomass fuel use on household air pollution (HAP) as well as the effects of HAP (fine particulate matter, PM2.5) on birth outcomes and acute lower respiratory infection (ALRI) among infants in Bangladesh.ParticipantsWe recruited 903 women within 18 weeks of pregnancy from rural and semiurban areas of Bangladesh between November 2016 and March 2017. All women and their infants (N=831 pairs) were followed until 12 months after delivery and a subset have undergone respiratory and gut microbiota analysis.MethodsQuestionnaires were administered to collect detailed sociodemographic, medical, nutritional and behavioural information on the mother–child dyads. Anthropometric measurements and biological samples were also collected, as well as household PM2.5concentrations.Findings to datePublished work in this cohort showed detrimental effects of biomass fuel and health inequity on birth outcomes. Current analysis indicates high levels of household PM2.5being associated with cooking fuel type and infant ALRI. Lastly, we identified distinct gut and respiratory microbial communities at 6 months of age.Future plansThis study provides an economical yet effective framework to conduct pregnancy cohort studies determining the health effects of adverse environmental exposures in low-resource countries. Future analyses in this cohort include assessing the effect of indoor PM2.5levels on (1) physical growth, (2) neurodevelopment, (3) age of first incidence and frequency of ALRI in infants and (4) the development of the respiratory and gut microbiome. Additional support has allowed us to investigate the effect of in utero exposure to metals on infant neurodevelopment in the first year of life.

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“…Recently, several studies reported that prenatal ETS exposure and solid/biomass fuel use were associated with PTB (Jaakkola et Younger et al 2021). Moreover, other studies also indicated that household renovation exposure within one year before pregnancy or during pregnancy may be a risk factor for PTB (Liu et al 2018, Liu et al 2019, Pan et al 2022). Furthermore, some harmful compositions commonly contained in household air pollutants, such as ne particular matters (PM 2.5 ), formaldehyde (FA) and polycyclic aromatic hydrocarbons (PAHs), have been reported to be associated with PTB and the length of gestation (Agarwal et al 2018, Amiri et al 2015, Shezi et al 2022.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, two prior studies found that household renovation during pregnancy was associated with the increased risk of PTB(Liu et al 2018, Liu et al 2019. A prospective cohort study in rural China found that housing renovation within one year before pregnancy was associated with PTB(Pan et al 2022).…”

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confidence: 99%

Joint effects of prenatal household air pollution exposure from multiple sources on preterm birth - A case-control study with propensity score matching

Liu

Strodl

Yang

et al. 2022

Preprint

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Prenatal exposure to household air pollution (HAP) has been suggested as a major risk factor for preterm birth (PTB). However, the effects of simultaneous prenatal exposure to multiple HAP sources on PTB have rarely been studied. We therefore conducted a case-control study on 21995 mother-child dyads after propensity score matching (PSM). After PSM, a series of logistic regression analysis on associations of environmental tobacco smoke (ETS), cooking oil fumes (COFs), burning mosquito coil (BMC), indoor burning incense (IBI) and household renovation (HR) with PTB were conducted to evaluate their independent and joint effects on PTB. Compared to mothers without exposure, prenatal exposure to each individual HAP source increased the PTB risk. Moreover, the accumulative effects of prenatal exposure to five sources of HAP on the risk of PTB were observed. Finally, we found synergistic effects between prenatal exposure to COFs and IBI, as well as between BMC and IBI, on PTB on both multiplicative and additive scales. Our results suggest that prenatal exposure to different sources of HAP might increase the risk of PTB and that accumulative effects, as well as synergistic interactions, between different HAP sources on PTB might exist.

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Effects of household environmental exposure and ventilation in association with adverse birth outcomes: A prospective cohort study in rural China

Cited by 15 publications

References 50 publications

First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

Cohort profile: Bangladesh Cook Stove Pregnancy Cohort Study (CSPCS)

Joint effects of prenatal household air pollution exposure from multiple sources on preterm birth - A case-control study with propensity score matching

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