Effects of Housing Conditions on the Development of Wet Skin Lesions in the NOA Mouse

Development of Dry Skin in the NOA Mouse Under Individual Housing Conditions: A Potentially Useful Animal Model for Evaluating Moisturizing Effects

“…All of the NOA mice used were bred at our facility. The breeding conditions were described in our previous report [14]. SAS software (SAS Institute Japan, Ltd., Tokyo, Japan) was used for statistical analysis.…”

“…This mouse strain spontaneously develops ulcerative and erosive wet skin lesions at a high rate [13]. In a previous study, we investigated the effects of housing conditions on the onset and prevalence of such wet skin lesions, and the results suggested the involvement of socio-psychological factors in the etiology of these lesions [14]. In addition, we noted new grossly observable characteristics with special regard to the development of dry skin in all of the NOA mice under individual housing conditions.…”

“…In addition, we noted new grossly observable characteristics with special regard to the development of dry skin in all of the NOA mice under individual housing conditions. Therefore, based on the observation that dry skin develops in individually housed NOA mice, this strain may be expected to serve as a useful animal model for evaluating the efficacy of topical moisturizers [14]. In the present study, dermal physiological function tests were carried out in order to more clearly characterize this dry skin model.…”

Increased Susceptibility to Staphylococcus aureus Colonization of the Skin of the NOA mouse: A Potentially Useful Animal Model for Evaluating Antiseptic Effects

“…Since psychosocial factors are thought to be involved in the development and aggravation of such skin lesions, the NOA mouse can be expected to serve as a useful animal model for analyzing the relationships between dermatopathy and psychological conditions [10]. 3) When NOA mice were housed individually, dry skin developed in all animals [10], and a marked decrease was observed in the water content of the stratum corneum [11]. Applying ointment to the dry skin restored the water content in proportion to the oil content of the ointment.…”

Pathology of Spontaneous Dermatitis in CBy.ALY-aly Mice

“…IgE has been proposed to play a key role in AD, because most AD patients have high levels of IgE, mainly directed to environmental antigens [10]. Spontaneous mouse models of dermatitis such as NC/Nga [7], DS-Nh [12] and NOA [3] also show high levels of IgE in the blood. Other studies, however, have shown that IgE levels are not correlated with the course of clinical development [2] and that some AD patients do not show elevated IgE levels [13].…”