Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levels

Molecular forms of natriuretic peptides in heart failure and their implications

“…Previous receptor occupation by endogenous active natriuretic peptides is expected to decrease the availability of the receptor for subsequent exogenous natriuretic peptides. Nakajima et al 38 infused ANP into two groups of patients with low and high iBNP levels. The low iBNP group had a much greater improvement in left ventricular contractility and reduction of arterial pressure when compared with the response of the high iBNP group.…”

Novel Diuretic Strategies for the Treatment of Heart Failure in Japan

“…We previously demonstrated that carperitide infusion increased cGMP generation, decreased afterload and preload, and improved left ventricular systolic and diastolic function in in patients with congestive HF. 61, 62 Although hypotension is a potential adverse effect of carperitide when administered at a high dose, the administration of low-dose carperitide in patients with ADHF has been demonstrated to improve the long-term (18-month) outcome. 15 Intermittent intravenous infusion of carperitide can be given in the outpatient setting and may decrease the length and number of rehospitalizations in patients with advanced HF.…”

Right Ventricle in Pulmonary Hypertension

“…ANP was infused in 20 patients with LV failure and high plasma BNP levels and improvement of LV diastolic dysfunction was documented (126), but no such data are available in patients with RV failure. A single case report showed a significant decrease of the pulmonary artery pressure in a patient with severe PAH following a short-term infusion of synthetic ANP (112).…”