Effects of Human Growth Hormone in Man *

Henneman, Philip H.; Forbes, Alexander; Moldawer, Marc; Dempsey, Eleanor; Carroll, Evelyn L.

doi:10.1172/jci104138

Cited by 229 publications

(73 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Basal metabolic rate does rise in some subjects, but not in all [2,14,24]; some authors report slight increases in serum PBI, others no change [14,17,39]; radioiodine uptake in the thyroid does not change [14,39]. The subjects studied by Prader et al [24] had hypercalcuria in the absence of a rise in BMR, and we could not demonstrate a quantitative relationship between the rise in BMR and the rise in urine Ca in our subjects.…”

Section: Discussioncontrasting

confidence: 60%

“…Shepard et al [31] and Henneman et al [14] were among the first to claim that the hypercalcuria was due to increased gastrointestinal absorption. But there are conflicting reports in the subsequent literature.…”

Section: Discussionmentioning

confidence: 99%

“…A commonly held assumption, based largely on the early studies of Shepard et al [31] and Henneman et al [14] is that the hypercalcuria is secondary to increased gastrointestinal absorption. Fraser and Harrison's [11] work with rats suggests that it is mediated via the parathyroid glands.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

et al. 1972

View full text Add to dashboard Cite

ExtractThe effect of human growth hormone (GH) administration (5 mg daily) was studied in 12 children with short stature, in an attempt to elucidate the cause of the hypercalcuria which so commonly occurs at the initiation of GH therapy. Complete metabolic balances were determined for Ca, P, N, Na, K, and Cl; and urine was analyzed for hydroxyproline, stable Sr, Pb, Mg, 137 Cs, F, and creatinine. Some subjects had determinations of basal metabolic rate (BMR) and of ultrafiltrable serum Ca. In keeping with the reports of others, levels of N, P, K, Na, and Cl in urine all declined, as did that of 187 Cs; Mg excretion fell slightly. Ten of the 12 children with short stature (6 of whom had subnormal plasma GH responses to a variety of stimuli) had hypercalcuria; 3 of these had an increase in urine Ca in the face of a low Ca diet (170 mg/24 hr). Fecal Ca declined in some subjects and rose in others. Ultrafiltrable serum Ca did not change.A majority of the subjects showed an increase in the urinary excretion of F, Sr, Pb, and hydroxyproline.The effect of the hormone was also studied in three patients with idiopathic hypoparathyroidism; two of these responded with an increase in urine Ca.The magnitude of the rise in urine Ca could not be correlated with changes in BMR, changes in creatinine clearance, or changes in Na excretion; it was positively correlated with the increases in Sr and Pb in urine. SpeculationWe have evidence that the hypercalcuria accompanying GH administration is not due to increased gastrointestinal absorption, alterations in serum Ca, or changes in metabolic rate or renal function; nor is it mediated via parathyroid activity. These considations, plus the fact that the hypercalcuria is accompanied by hydroxyprolinuria and an increase in the urinary excretion of three "bone seekers" (Sr, Pb, and F), lead us to postulate that the hormone enhances bone resorption, either per se or via "sulfation factor."

show abstract

Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

et al. 1972

View full text Add to dashboard Cite

show abstract

“…The recognition that GH has antinatriuretic actions has been established for many years (24). The sodium retention and increased TBW observed in subjects with acromegaly (25) and in the early studies of GH replacement for longitudinal growth in childhood (26) demonstrated a clear pharmacological effect of GH on fluid homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Interdependence of lean body mass and total body water, but not quality of life measures, during low dose GH replacement in GH-deficient adults

Mukherjee

Adams²,

Smethurst³

et al. 2005

eur j endocrinol

View full text Add to dashboard Cite

Lean body mass (LBM) and total body water (TBW) are reduced in GH-deficient (GHD) adults and alter with GH replacement. Whether these parameters are interdependent and whether alterations in their homeostasis contribute to the perceived quality of life (QOL) deficit in GHD remains unclear. In this study, IGF-I, body composition by whole-body dual-energy X-ray absorptiometry, TBW by deuterium dilution (D 2 O) and two validated QOL instruments -psychological general well-being schedule (PGWB, generic, 6 domains; lower score worse QOL) and assessment of GH deficiency in adults (AGHDA, disease orientated; higher score worse QOL) were studied at baseline and after 3 and 6 months of GH replacement in thirty GHD adults. Patients with diabetes insipidus, and cardiac and renal failure were excluded. Median age-adjusted IGF-I standard deviation score increased from 2 3.40 (26.40 to 2 1.60) to 2 0.2 (2 1.88 to 0.78) (P , 0.0001) at a median daily GH dose of 0.4 mg. During treatment, LBM increased from 47.4^10.7 kg at baseline to 49.5^10.8 kg at 6 months (P ¼ 0.0008), and fat mass decreased from 28.0^12.1 kg at baseline to 27.2^12.6 kg at 6 months (P ¼ 0.0004). A non-significant trend towards an increase in TBW was observed (mean 1.7 kg, P ¼ 0.08). The PGWB score increased from 62.9^20.6 to 73.7^21.7 (P ¼ 0.0006). The AGHDA score decreased from 13.7^7.3 to 8.75^7.75 (P ¼ 0.0002). At each time point, a linear correlation between LBM and TBW was demonstrated, defined by TBW ¼ (0.972 £ LBM)-10.6. However, only a weakly positive correlation existed between the percentage changes in these variables (R ¼ 0.40, P ¼ 0.04). No correlations were demonstrated between QOL measures and body composition. The change in LBM with physiological GH replacement correlates weakly with change in TBW, therefore factors other than TBW may also contribute to the LBM changes. Improved QOL with GH replacement is not explained by favourable changes in body composition.European Journal of Endocrinology 153 661-668

show abstract

“…GH administration has been reported to exert no distinct alteration in thyroid function [1], but to induce decreased serum TSH responses to thyrotropin releasing hormone [2], increased serum triiodothyronine (T3) with no change in thyroxine (T4) levels [3], and enhanced peripheral conversion of T4 to T3 in GH-deficient patients [4]. In normal men there have been few reports on the effects of GH administration on thyroid function.…”

mentioning

confidence: 99%

Mild Serum Thyroid Hormone Increase during and after Five-Day Administration of Human Growth Hormone in Healthy Male Adults

1998

View full text Add to dashboard Cite

Effects of Human Growth Hormone in Man *

Cited by 229 publications

References 11 publications

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

Metabolic Response to Growth Hormone Administration, with Particular Reference to the Occurrence of Hypercalcuria

Interdependence of lean body mass and total body water, but not quality of life measures, during low dose GH replacement in GH-deficient adults

Mild Serum Thyroid Hormone Increase during and after Five-Day Administration of Human Growth Hormone in Healthy Male Adults

Contact Info

Product

Resources

About