Effects of Hyaluronate Sodium on Pain and Physical Functioning in Osteoarthritis of the Knee

Petrella, Robert J.; DiSilvestro, Mathew Dennis; Hildebrand, Catherine

doi:10.1001/archinte.162.3.292

Cited by 132 publications

(50 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The procedure is associated with few local adverse events and decreases the need for concomitant analgesia/ therapeutic modalities. Activity related pain seems to respond better to HA injection which is similar to previous studies [36]. The need for long-term study cannot be over emphasized.…”

Section: Resultssupporting

confidence: 88%

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

Hussain¹,

Rather²,

Qayoom³

2014

J Trauma Treat

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 88%

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

Hussain¹,

Rather²,

Qayoom³

2014

J Trauma Treat

View full text Add to dashboard Cite

“…Only 4 trials reported concealment of allocation and blinding of the outcome observer, and presented data from an intention-to-treat analysis. 12,22,31,33 Seven trials reported allocation concealment. 12,22,29,[31][32][33][34] Eight trials reported an intention-to-treat analysis, but only 6 of these presented data that could be extracted from the intention-to-treat analysis.…”

Section: Trial Qualitymentioning

confidence: 99%

Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis

Arrich

Piribauer²,

Mad³

et al. 2005

Canadian Medical Association Journal

281

182

View full text Add to dashboard Cite

Review SynthèseO steoarthritis affects about 10% of the population over 55 years of age. Of those, one-quarter are severely disabled.1 The condition is characterized by degeneration of the articular cartilage and subsequent subchondral bone changes. The underlying mechanisms remain unknown, but the glycosaminoglycan-proteoglycan matrix may play a major role. 2 Hyaluronic acid, a glycosaminoglycan, is widely used for the treatment of osteoarthritis of the knee. A survey of 2 general practices in the United Kingdom showed that about 15% of patients with osteoarthritis received intraarticular treatment with glucosamine sulfates. 3 The costs of such treatment are significant. At present, 1 syringe of hyaluronic acid costs at least Can$130 (US$110). The treatment of knee osteoarthritis is covered by the US Medicare program but not by provincial formularies in Canada. In Austria (which has 8 million inhabitants) more than 10 million euros (approximately US$12 million or Can$15 million) is spent by social insurance programs annually for hyaluronic acid preparations (excluding the cost of application).Hyaluronic acid has beneficial effects in vitro. 4 Because of its viscoelastic quality, it may replace synovial fluid. Furthermore, it may reduce the perception of pain. Beneficial molecular and cellular effects have also been reported. 2,4Hyaluronic acid is frequently applied by intra-articular injection, but the evidence concerning its clinical relevance is conflicting. The European League against Rheumatism (EULAR) recommends the intra-articular application of hyaluronic acid as "category 2" evidence (at least 1 controlled study without randomization). 5 The American College of Rheumatology recommends intra-articular hyaluron therapy for patients with no response to nonpharmacologic therapy and simple analgesics. 6 In contrast, other specialists have concluded that "hyaluronate sodium is not efficacious" in the treatment of osteoarthritis. 7 The first state-of-the-art systematic review and meta-analysis was published recently, 8 and its authors concluded "that intra-articular hyaluronic acid, at best, has a small effect."We performed a systematic review and meta-analysis of Abstract Background: Osteoarthritis of the knee affects up to 10% of the elderly population. The condition is frequently treated by intra-articular injection of hyaluronic acid. We performed a systematic review and meta-analysis of randomized controlled trials to assess the effectiveness of this treatment. Methods: We searched MEDLINE, EMBASE, CINAHL, BIOSISand the Cochrane Controlled Trial Register from inception until April 2004 using a combination of search terms for knee osteoarthritis and hyaluronic acid and a filter for randomized controlled trials. We extracted data on pain at rest, pain during or immediately after movement, joint function and adverse events. Results: Twenty-two trials that reported usable quantitative information on any of the predefined end points were identified and included in the systematic review. Even though pain at res...

show abstract

“…55 Viscosupplementation with hyaluronan is as effective as NSAIDs for improving resting pain and may provide superior relief from pain with physical activity (recommendation strength A). 56 Intraarticular injections are usually completed as a series of 3 to 5 injections with benefits lasting 12 weeks or longer. 56 Two hyaluronan compounds (high molecular weight and low molecular weight) with no appreciable difference in efficacy are commercially available (recommendation strength A).…”

Section: Office Interventionsmentioning

confidence: 99%

“…56 Intraarticular injections are usually completed as a series of 3 to 5 injections with benefits lasting 12 weeks or longer. 56 Two hyaluronan compounds (high molecular weight and low molecular weight) with no appreciable difference in efficacy are commercially available (recommendation strength A). 57 Acupuncture has also been shown to have benefits in relieving chronic symptoms in limited studies (recommendation strength B).…”

Section: Office Interventionsmentioning

confidence: 99%

Managing Joint Pain in Primary Care

Palmer¹,

Toombs²

2004

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

Joint pain is a common problem seen by family physicians. Although many pain complaints arise from self-limited conditions, a substantial number require immediate and ongoing care. Prompt appropriate treatment can help limit symptoms, prevent disability, and improve outcomes. The differential diagnosis is varied, with both laboratory studies and diagnostic imaging available to help evaluate the joint. At the initial evaluation and at each subsequent re-evaluation, there should be efforts to identify dangerous conditions and distinguish conditions with a disease-specific pathogenesis. Treatment of joint pain consists of both pharmacologic and nonpharmacologic modalities. Pharmacologic therapies may include medications specific for pain, inflammation, and adjuncts specific to the diagnosis. Joint pain is a common complaint presented by patients to family physicians. Each year there are more than 315 million office visits for musculoskeletal complaints.

show abstract

Effects of Hyaluronate Sodium on Pain and Physical Functioning in Osteoarthritis of the Knee

Abstract: For resting pain relief, hyaluronate sodium seems to be as effective as NSAIDs. Further, for pain with physical activity and functional performance, hyaluronate sodium may be superior to placebo alone or NSAIDs alone.

Cited by 132 publications

References 24 publications

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis

Managing Joint Pain in Primary Care

Contact Info

Product

Resources

About