Effects of Hyaluronic Acid on the Polymorphonuclear Leukocyte (PMN) Release of Active Oxygen and Protection of Bovine Corneal Endothelial Cells from Activated PMNs

Antioxidant activity of hyaluronic acid investigated by means of chemiluminescence of equine neutrophil bursts and electron paramagnetic resonance spectroscopy

“…The direct antiradical activity observed with EPR and ABTS • + radicals, and the LACL data with equine neutrophils are in line with the concept that hyaluronic acid mainly acts as a chemical ROS/RNS scavenger in extracellular space, as reported by other authors (Lym et al ., ; Krasinski et al ., ). The scavenger ability of hyaluronic acid towards ABTS, DPPH and hydroxyl radicals has also been confirmed by means of photometric methods using a hyaluronic acid from marine bivalve mollusc (Kanchana et al ., ).…”

Efficacy of barriers and hypoxia-inducible factor inhibitors to prevent CO2 pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model

“…49 On the other hand, HA can act as a reactive oxygen species scavenger. 50,51 It was recently demonstrated that HA increases the proliferation rate of human peritoneal mesothelial cells 52 and increases the fibrinolytic response. 53 Although some decrease in adhesion formation was observed with CMC 2% in our laparoscopic model, the differences were not statistically significant.…”

Adverse reactions to injectable soft tissue fillers

“…Here, it functions as a hygroscopic material because it is capable of capturing large amounts of water, as seen in wound healing 55,56 and in the lubrication of joints. 57 Hyaluronic acid also acts as an important free radical scavenger, 58 and it may indirectly stimulate some neocollagenogenesis after injection through mechanical stretching of the dermis and subsequent activation of dermal fibroblasts. 59 Injections of hyaluronic acid gel are used for filling out wrinkles of the face, for soft tissue augmentation, and for the correction of all types of defects, such as scars and facial lipoatrophy.…”