Effects of hydroxyapatite dosage on mechanical and biological behaviors of polylactic acid composite materials

Lin, Po Liang; Fang, Hsu Wei; Tseng, Tiffany; Lee, Wun Hsing

doi:10.1016/j.matlet.2006.10.064

Cited by 79 publications

(70 citation statements)

References 11 publications

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“…This anti-inflammatory property, which was expected from this formulation, is in accordance with other studies. 28,29 After 20 days, while the PLGA formulation was extensively degraded (Figure 9A), PLGA-HA was only partially disrupted ( Figure 9B). Slower degradation of PLGA-HA is due to the presence of HA.…”

Section: Prediction Optimization and Characterizationmentioning

confidence: 99%

“…In addition, HA degradation in pH , 4.2 has been investigated previously. 29 This biodegradation releases Ca 2+ and the result is pH buffering capacity. This can be combined with the anti-inflammatory properties of TR for better control of inflammation due to PLGA hydrolysis at the injection site, using this optimized formulation.…”

Section: Prediction Optimization and Characterizationmentioning

confidence: 99%

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Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide

Koocheki

Madaeni²,

Niroomandi³

2011

IJN

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We report an analysis of in vitro and in vivo drug release from an in situ formulation consisting of triamcinolone acetonide (TR) and poly( d , l -lactide-co-glycolide) (PLGA) and the additives glycofurol (GL) and hydroxyapatite nanoparticles (HA). We found that these additives enhanced drug release rate. We used the Taguchi method to predict optimum formulation variables to minimize the initial burst. This method decreased the burst rate from 8% to 1.3%. PLGA-HA acted as a strong buffer, thereby preventing tissue inflammation at the injection site caused by the acidic degradation products of PLGA. Characterization of the optimized formulation by a variety of techniques, including scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and Fourier transform near infrared spectroscopy, revealed that the crystalline structure of TR was converted to an amorphous form. Therefore, this hydrophobic agent can serve as an additive to modify drug release rates. Data generated by in vitro and in vivo experiments were in good agreement.

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Section: Prediction Optimization and Characterizationmentioning

confidence: 99%

Section: Prediction Optimization and Characterizationmentioning

confidence: 99%

Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide

Koocheki

Madaeni²,

Niroomandi³

2011

IJN

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“…Assim, muitos estudos têm se dedicado à modificação dos biopolímeros na viabilização do processamento e utilização dos mesmos em diversas aplicações. [49] Para isso, foram desenvolvidas blendas poliméricas [50] , compósitos poliméricos [51,52] e nanocompósitos poliméricos [53,54] , que apresentam melhorias nas propriedades de processabilidade, resistência térmica, propriedades mecânicas, propriedades reológicas, permeabilidade a gases e taxa de degradação.…”

Section: Biopolímeros E Polímeros Biodegradáveisunclassified

Obtenção e caracterização de PLA reforçado com nanocelulose.

Correia¹

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AGRADECIMENTOSAos meus pais, simplesmente por tudo! Pelo amor incondicional, carinho, dedicação e por terem me apoiado em todas minhas decisões. Ao meu irmão Augusto e meu namorado Bruno pelo companheirismo, toda compreensão e força nos momentos difíceis. Sem vocês nada disso faria sentido! Amo muito vocês! À Prof.ª Dra. Ticiane Sanches Valera pela orientação, atenção e apoio ao longo de todo este trabalho. Obrigada por ter me acolhido, por me apresentar este tema com o qual adorei trabalhar e, acima de tudo, obrigada pelo exemplo e pelos conhecimentos compartilhados! Ao meu coorientador Prof. Dr. Marcio Yee, Universidade Federal de São Paulo (UNIFESP), pela disponibilidade, mesmo trabalhando em outra cidade! Obrigada por ter me apresentado à Prof.ª Ticiane, pela paciência, compreensão e o enorme suporte que me proporcionou! Sem você tudo seria muito mais difícil!! Aos meus queridos amigos e colegas do Laboratório de Polímeros! Obrigada a todos por me ajudarem a fazer tudo isso dar certo! Obrigada a Fernanda, Nati e Kleber pelas conversas, pelas risadas, pelos chocolates (Kleber, nem um caminhão da Lacta poderia pagar por eles...), enfim, obrigada pela amizade única!! Às alunas mais novas Anita e Suellen. Su, obrigada por toda a ajuda no trabalho, espero que continuemos firmes e fortes para prosseguir com os trabalhos futuros! Obrigada Camila pela enorme ajuda em tudo que parecia que não ia dar certo, sua experiência no Laboratório é única e fez (e ainda faz) a diferença, muito Obrigada Palavras-chave: celulose, nanopartículas, biopolímeros, nanocompósitos, reologia. ABSTRACTCellulose is the renewable natural polymer currently available in greatest abundance. Cellulose is a semicrystalline polymer, and it is possible to extract its crystalline domains through a procedure that destroys its amorphous phase, such as acid etching, so obtaining crystalline cellulose particles called cellulose nanoparticles (NC). These nanoparticles have attracted great scientific interest because they have mechanical properties similar to those of many inorganic types of filler used in polymer matrix composites, like elastic modulus and tensile strength. Moreover, they have nanometric dimensions, which contribute to lower filler contents in the polymer matrix, due to its increased surface area when compared to the one of micrometric fillers. Nanocomposites formed by adding these fillers into polymeric matrices can present attractive commercial properties such as gas barrier, improved thermal properties, and low density, when compared to traditional composites. As NC are nanometric scale fillers, obtained from renewable sources, there is a great interest in their application into biodegradable biopolymer matrixes. Poly (lactic acid), PLA, is an example of biopolymer that presents improved thermal, mechanical and processing properties, when compared to the ones of other commercial biopolymers. In this work, cellulose nanoparticles (NC) were obtained, via acid hydrolysis, using three different methods, in order to study the most efficie...

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“…[238] [239,240] patite can ticles has on. [241][242][243] materials, particularly ceramics, surgeons are increasingly demanding for instructive biomaterials with improved mouldability. Such materials should allow surgeons to easily and quickly fit them in the defect with the guarantee of their instructive characteristics and initial stability in the site.…”

Section: Instructive Factors In Tissuesmentioning

confidence: 99%

“…[241] Further, the presence of hydroxyapatite particles increased protein adsorption and enhanced osteoblast adhesion. [241][242][243] So far, only one composite of polyester and ceramic has been reported to be osteoinductive [235] and, to our best knowledge, no literature about the effects of ceramic filler content on composite-related osteoinduction is available. In the current study we present an approach to produce instructive composites by introducing different amounts of nano-sized apatite into poly(D,L-lactic acid).…”

Section: Introductionmentioning

confidence: 99%

Instructive composites for bone regeneration

Barbieri¹

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Effects of hydroxyapatite dosage on mechanical and biological behaviors of polylactic acid composite materials

Cited by 79 publications

References 11 publications

Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide

Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide

Obtenção e caracterização de PLA reforçado com nanocelulose.

Instructive composites for bone regeneration

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