Effects of hydroxychloroquine on proteinuria in membranous nephropathy

Cheng, Yan-Jiao; Cheng, Xuyang; Zhang, Yimiao; Wang, Fang; Wang, Xin; Meng, Liqiang; Liu, Gang; Cui, Zhao; Zhao, Ming‐Hui

doi:10.1007/s40620-021-01182-z

Cited by 6 publications

(3 citation statements)

References 51 publications

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“…Hydroxychloroquine can play a role in immunoregulation by suppressing the proliferation of T lymphocytes and reducing the production of cytokines [9]. It has been reported that hydroxychloroquine is helpful for the remission of patients with MN [5].…”

Section: Discussionmentioning

confidence: 99%

“…Hydroxychloroquine plays a key role in inhibiting the plasmodial heme polymerase and has been used in the treatment of some autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and antiphospholipid antibody syndrome. Furthermore, a new study suggested that hydroxychloroquine therapy was associated with higher rates of proteinuria and anti-phospholipase A2 receptor ( anti-PLA2R) reduction in patients with MN [5]. Herein, we first described the effect of RTX combined with hydroxychloroquine treatment in a patient with MN and DN.…”

Section: Introductionmentioning

confidence: 99%

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Treatment with rituximab and hydroxychloroquine in a patient with membranous nephropathy and diabetic nephropathy: A case report

Ning¹,

Xu²,

Chen³

et al. 2023

Diabetic Nephropathy

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Nephrotic syndrome (NS), which includes primary and secondary types, is one of the causes of end-stage kidney disease. Common causes in adults include diabetic nephropathy (DN), membranous nephropathy (MN), and focal segmental glomerulosclerosis. About 30%–40% of diabetics can develop into DN. The incidence of primary nephrotic syndrome in diabetic patients was not significantly different from that in the general population. Herein we present a windfall from the treatment of rituximab combined with hydroxychloroquine in a patient with primary MN and DN. A 51-year-old Chinese man, diagnosed with type 2 diabetes mellitus (T2DM) 12 years ago, was admitted to the hospital due to edema of bilateral lower limbs and severe proteinuria. Serology showed the obvious elevation of the anti-phospholipase A2 receptor (anti-PLA2R) level and renal biopsy showed MN concomitant with DN. After low dosage of prednisone and standard dosage of rituximab, the patient’s proteinuria decreased; however, the effect was unsatisfactory and proteinuria was elevated again in 8 months. Thus, treatment with rituximab and hydroxychloroquine was initiated, which resulted in proteinuria diminishing significantly and albumin returning to normal level. Therefore, even complicated with DN, patients diagnosed with primary MN still have a promising remission after being treated with rituximab and hydroxychloroquine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment with rituximab and hydroxychloroquine in a patient with membranous nephropathy and diabetic nephropathy: A case report

Ning¹,

Xu²,

Chen³

et al. 2023

Diabetic Nephropathy

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“…The different methods for the synthesis of nanoparticles are broadly categorized as physical, chemical, and biological methods [42–56]. The physical methods, based on the “top‐down” approach, involve techniques such as mechanical milling, thermal decomposition, sputtering, laser ablation, and lithography.…”

Section: Synthesis Of Nanoparticlesmentioning

confidence: 99%

Recent trends and advancements in synthesis and applications of plant‐based green metal nanoparticles: A critical review

Guleria

Sachdeva

Saini

et al. 2022

Applied Organom Chemis

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Metal nanoparticles have emerged as immensely desired materials because of their wide array of applications as antimicrobial agents, catalysts, nanomagnets, biosensors, environmental remediating agents, and so forth, but the problem lies with the traditional methods of their synthesis. These methods of synthesis are expensive, complex, less efficient, and hazardous to the environment. Thus, it calls for the development of greener and environmentally benign methods of their synthesis. Researchers worldwide have been vigorously trying to develop safer, simple, efficient, scalable, and eco-friendly methods to synthesize different metal nanoparticles. For this, various green protocols using diversified species of plants, algae, fungi, bacteria, and other microorganisms have been successfully developed.The purpose of this study is to give a detailed account of recent trends in synthesis and diverse applications of plant-based green metal nanoparticles. Plant-mediated synthesis of nanoparticles has emerged as the most soughtafter route since it is economical, convenient, rapid, reliable, stable, and can be used for large-scale productions. The plant-based nanoparticles have also exhibited a broad spectrum of applications in the fields of biomedicine, chemistry, physics, and environmental sciences. This study provides a comprehensive overview of the recent advances in plantmediated green synthesis of metal nanoparticles, their plausible synthetic mechanism, characterization techniques, and factors affecting their synthesis.This article also provides insights into the diverse applications exhibited by the nanoparticles covering their mechanistic aspects.

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Association of rheumatoid arthritis with mortality in chronic kidney disease: a cohort study

et al. 2022

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Effects of hydroxychloroquine on proteinuria in membranous nephropathy

Cited by 6 publications

References 51 publications

Treatment with rituximab and hydroxychloroquine in a patient with membranous nephropathy and diabetic nephropathy: A case report

Treatment with rituximab and hydroxychloroquine in a patient with membranous nephropathy and diabetic nephropathy: A case report

Recent trends and advancements in synthesis and applications of plant‐based green metal nanoparticles: A critical review

Association of rheumatoid arthritis with mortality in chronic kidney disease: a cohort study

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