Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

Al-Waili, Noori S.; Butler, Glenn

doi:10.1100/tsw.2006.78

Cited by 117 publications

(89 citation statements)

References 118 publications

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“…Interestingly, like hypoxia, hyperoxia also induces the expression of angiogenic factors and supports wound angiogenesis and healing (2,(15)(16)(17). Oxygen therapy is commonly used in the wound clinics to treat wound hypoxia (20)(21)(22)(23)(24). Extreme hyperoxia, on the other hand, can cause oxygen toxicity and derail tissue repair (16,17,19).…”

mentioning

confidence: 99%

Wound angiogenesis as a function of tissue oxygen tension: A mathematical model

Schugart

Friedman

Zhao

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

165

188

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mentioning

confidence: 99%

Wound angiogenesis as a function of tissue oxygen tension: A mathematical model

Schugart

Friedman

Zhao

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

165

188

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“…HBO treatment is relatively safe (83,84), and some studies have shown it has anti-inflammatory activity (85)(86)(87). These features support further research into HBO treatment as an adjunctive therapy candidate for a wide range of diseases (88).…”

Section: Hyperbaric Oxygenmentioning

confidence: 89%

Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria

et al. 2016

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cOver 200 million people worldwide suffer from malaria every year, a disease that causes 584,000 deaths annually. In recent years, significant improvements have been achieved on the treatment of severe malaria, with intravenous artesunate proving superior to quinine. However, mortality remains high, at 8% in children and 15% in adults in clinical trials, and even worse in the case of cerebral malaria (18% and 30%, respectively). Moreover, some individuals who do not succumb to severe malaria present longterm cognitive deficits. These observations indicate that strategies focused only on parasite killing fail to prevent neurological complications and deaths associated with severe malaria, possibly because clinical complications are associated in part with a cerebrovascular dysfunction. Consequently, different adjunctive therapies aimed at modulating malaria pathophysiological processes are currently being tested. However, none of these therapies has shown unequivocal evidence in improving patient clinical status. Recently, key studies have shown that gaseous therapies based mainly on nitric oxide (NO), carbon monoxide (CO), and hyperbaric (pressurized) oxygen (HBO) alter vascular endothelium dysfunction and modulate the host immune response to infection. Considering gaseous administration as a promising adjunctive treatment against severe malaria cases, we review here the pathophysiological mechanisms and the immunological aspects of such therapies. Malaria exerts a heavy burden over human populations, with an estimated 124 to 283 million cases and 584,000 deaths in 2013 (1). Currently, intravenous (i.v.) artesunate is the treatment of choice in severe malaria cases in children and adults (2, 3). However, despite the efficacy of intravenous artesunate, mortality from severe malaria in general and from cerebral malaria (CM) in particular remains high, at 18% for African children and 30% for adults in Southeast Asia (2, 3). In addition, 11% of children who survive CM show severe neurological deficits, and up to 25% can maintain long-term cognitive deficits (4-8). Therefore, strategies focusing only on parasite killing may not be sufficient to prevent neurological complications and deaths related to severe malaria. Accordingly, adjunctive therapies-defined as therapies administered in combination with antiparasitic drugs that modify pathophysiological processes caused by malaria-are being sought in order to mitigate complications caused by severe malaria (9). Considering the fact that currently administered antimalarial drugs often take 12 to 18 h to kill parasites, adjunctive therapies could reduce the risk of neurocognitive sequelae and mortality, particularly in patients with CM (10).Different adjunctive therapies have been or are being tested, including treatments aimed at modulation of the immune response to infection (dexamethasone, intravenous immunoglobulin), reduction of iron burden, reduction of oxidative stress, modulation of the prothrombotic state, and reduction of parasitemia (blood transfusion), amon...

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“…In addition to cerebral hypoperfusion, a study published in 2005 shows at autopsy that children with autism have cerebral inflammation [14]. HBOT may be useful because of its anti-inflammatory effects [15]. The repetition of HBOT sessions also allows the stimulation of free radical scavengers, likely to block the initiation of pro-inflammatory state.…”

Section: Autismmentioning

confidence: 99%

Hyperbaric Oxygen Therapy: Focus

Oumri¹,

Badi²,

Khaloufi³

2018

OJEM

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Hyperbaric oxygen therapy is now an integral part of the current therapeutic arsenal, it is a treatment that has a large number of indications and which concerns several specialties. This development aims to summarize some main indications. KeywordsHyperbaric Oxygen Therapy DefinitionHyperbaric oxygen therapy is a mode of therapy that involves working at pressures three to four times higher than atmospheric pressure. These pressures are reached in a sealed chamber called hyperbaric therapeutic chamber. The treatment involves inhaling pure oxygen (100%) through a face mask into a patient placed in a hyperbaric chamber at a higher than normal atmospheric pressure (760 mm Hg or 1ATA). The pressure inside the box can reach 4 bars [1]. Mechanisms of ActionSeveral mechanisms are associated during the intermittent exposure of oxygen under pressure. The most important mechanisms are: "the Hyperpressionhyperbarie", the hyperventilation, "the anti-infective effect", the healing effect.

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Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

Cited by 117 publications

References 118 publications

Wound angiogenesis as a function of tissue oxygen tension: A mathematical model

Wound angiogenesis as a function of tissue oxygen tension: A mathematical model

Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria

Hyperbaric Oxygen Therapy: Focus

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