2017
DOI: 10.1007/s00464-017-5519-8
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Effects of hypercapnia on postoperative nausea and vomiting after laparoscopic surgery: a double-blind randomized controlled study

Abstract: Our data suggest that mild to moderate intraoperative hypercapnia did not decrease the incidence and severity of PONV or the requirement for rescue antiemetics after gynecologic laparoscopic surgery.

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Cited by 22 publications
(33 citation statements)
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“…10 Intraabdominal pressure and hypercapnia, induced by CO 2 pneumoperitoneum, is suggested as a cause of postoperative nausea vomiting (PONV) by gastrointestinal mucosa irritation and decreased blood flow in the gastrointestinal tract, which, in turn, induces serotonin release, although the exact cause is still not fully understood. 11,12 To overcome shoulder pain, PONV and decrease of cardiopulmonary function arising from CO 2 pneumoperitoneum, many trials of medications and low-pressure pneumoperitoneum have been conducted. Improvements have been shown, but they have been limited.…”
Section: Introductionmentioning
confidence: 99%
“…10 Intraabdominal pressure and hypercapnia, induced by CO 2 pneumoperitoneum, is suggested as a cause of postoperative nausea vomiting (PONV) by gastrointestinal mucosa irritation and decreased blood flow in the gastrointestinal tract, which, in turn, induces serotonin release, although the exact cause is still not fully understood. 11,12 To overcome shoulder pain, PONV and decrease of cardiopulmonary function arising from CO 2 pneumoperitoneum, many trials of medications and low-pressure pneumoperitoneum have been conducted. Improvements have been shown, but they have been limited.…”
Section: Introductionmentioning
confidence: 99%
“…In that trial, PaCO2 was measured indirectly by corrected EtCO2 (EtCO2 plus the difference between PaCO2 and EtCO2) during surgery. The incidence of nausea during a period of 24 hours after the operation was not significantly different among the three groups (54%, 48%, and 50%, respectively, p=0.59) [15].…”
Section: Comparison With Previous Studiesmentioning
confidence: 73%
“…The authors did not find an effect of different levels of PaCO 2 on the incidence of PONV. [ 23 ] The trend of lower incidence of PONV in our intervention group is likely due to the lower incidence and severity of pain in this group, a factor well-known for causing PONV. [ 24 ]…”
Section: Discussionmentioning
confidence: 99%