1994
DOI: 10.1002/nbm.1940070103
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Effects of hyperoxia on T and resonance frequency weighted magnetic resonance images of rodent tumours

Abstract: Experiments were performed to determine whether T2* and resonance frequency weighted MR images are sensitive to effects of hyperoxia on model tumors. Hyperoxia can increase tumor oxygen tension and thus affect T2* and/or the average resonance frequency within each image voxel due to the paramagnetism of oxygen itself or through modulation of the oxidation state of hemoglobin. Alternatively, changes in T2* during hyperoxia may reflect changes in tumor water content due to changes in systemic blood pressure. Mam… Show more

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Cited by 67 publications
(42 citation statements)
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“…The positive DR 2 * carbogen suggests that the blood concentration of deoxyhemoglobin increased during carbogen breathing in both these models. Such a response has been previously reported and attributed to a vascular steal effect, which is a systemic redistribution of blood away from the tumor (7,25). Additionally, an increase in fractional blood volume during carbogen breathing has been reported, which could also induce a positive DR 2 * carbogen (26).…”
Section: Global Tumor Dr 2 * Carbogen and Fractional Blood Volumementioning
confidence: 66%
“…The positive DR 2 * carbogen suggests that the blood concentration of deoxyhemoglobin increased during carbogen breathing in both these models. Such a response has been previously reported and attributed to a vascular steal effect, which is a systemic redistribution of blood away from the tumor (7,25). Additionally, an increase in fractional blood volume during carbogen breathing has been reported, which could also induce a positive DR 2 * carbogen (26).…”
Section: Global Tumor Dr 2 * Carbogen and Fractional Blood Volumementioning
confidence: 66%
“…A previous report (11) speculated that the hyperoxia-induced MR signal increase observed in rat tumors may result from changes in vascular resistance and therefore flow. However, tumor vessels are in general different from normal tissue.…”
Section: Discussionmentioning
confidence: 98%
“…In the context of many tumour studies we prefer to designate this as flow and oxygenation dependent (FLOOD) contrast in order to acknowledge that there are underlying physiological changes in tumours that are different to those that cause BOLD effects in the brain, as well as to emphasize the contribution of the flow component to changes in GRE image intensity and blood oxygenation. The use of BOLD/FLOOD contrast in tumours is a more recent area of research [2][3][4][5][6][7][8][9][10] than BOLD contrast in brain and brings with it new challenges of understanding and interpretation. This topic is beginning to attract much interest, because it offers a potential method for non-invasively monitoring tumour oxygenation.…”
Section: Introductionmentioning
confidence: 99%