Effects of hyperprolactinemia on osteoporotic fracture in premenopausal women

Vartej, Petrache; Poiană, Cătălina; Vartej, I.

doi:10.1080/713602650

Cited by 14 publications

(5 citation statements)

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“…Elevated risk for glucose dysregulation, weight gain and new onset diabetes has been observed with the use of antipsychotic and antidepressants medications [46-48]. Both typical and atypical antipsychotic medications are known to induce hyperprolactinemia [49] which leads to bone loss, a major risk factor for osteoporosis [50]. We tested this by additionally including psychotropic medication use in the complementary log-log regression models.…”

Section: Resultsmentioning

confidence: 99%

Excess risk of chronic physical conditions associated with depression and anxiety

2014

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BackgroundDepression and anxiety have been reported to be associated with chronic physical conditions. We examined the excess risk of chronic physical conditions associated with depression and/or anxiety within a multivariate framework controlling for demographic and modifiable lifestyle risk factors.MethodsWe used a retrospective cross-sectional study design. Study participants were adults aged 22–64 years from 2007 and 2009 Medical Expenditure Panel Survey. We defined presence of depression-anxiety based on self-reported depression and anxiety and classified adults into 4 groups: 1) depression only; 2) anxiety only; 3) comorbid depression and anxiety 4) no depression and no anxiety. We included presence/absence of arthritis, asthma, chronic obstructive pulmonary disorder, diabetes, heart disease, hypertension, and osteoporosis as dependent variables. Complementary log-log regressions were used to examine the excess risk associated with depression and/or anxiety for chronic physical conditions using a multivariate framework that controlled for demographic (gender, age, race/ethnicity) and modifiable lifestyle (obesity, lack of physical activity, smoking) risk factors. Bonferroni correction for multiple comparisons was applied and p ≤0.007 was considered statistically significant.ResultsOverall, 7% had only depression, 5.2% had only anxiety and 2.5% had comorbid depression and anxiety. Results from multivariable regressions indicated that compared to individuals with no depression and no anxiety, individuals with comorbid depression and anxiety, with depression only and with anxiety only, all had higher risk of all the chronic physical conditions. ARRs for comorbid depression and anxiety ranged from 2.47 (95% CI: 1.47, 4.15; P = 0.0007) for osteoporosis to 1.64 (95% CI: 1.33, 2.04; P < 0.0001) for diabetes. Presence of depression only was also found to be significantly associated with all chronic conditions except for osteoporosis. Individuals with anxiety only were found to have a higher risk for arthritis, COPD, heart disease and hypertension.ConclusionPresence of depression and/or anxiety conferred an independent risk for having chronic physical conditions after adjusting for demographic and modifiable lifestyle risk factors.

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Section: Resultsmentioning

confidence: 99%

Excess risk of chronic physical conditions associated with depression and anxiety

2014

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“…Studies in patients with hyperprolactinaemia secondary to prolactinomas have found high rates of osteopenia and osteoporosis (Vartej et al , ; Colao et al , ; Kayath et al , ). Prolactin regulates the secretion of gonadotrophins and hence influences the levels of the gonadal hormones oestradiol and testosterone.…”

Section: Introductionmentioning

confidence: 99%

Is antipsychotic treatment linked to low bone mineral density and osteoporosis? A review of the evidence and the clinical implications

Crews

Howes

2012

Human Psychopharmacology

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Objective-Osteoporosis is increasingly common worldwide and there is growing concern that the long-term use of antipsychotic medications increases the risk of this disorder. In this review we consider whether antipsychotics may contribute to the development of osteoporosis through reductions in bone mineral density (BMD), discuss the possible mechanisms involved and consider the clinical implications of such a relationship. Methods-We searched the literature for studies in this area published between 1966 and 2010 using the Medline and PubMed databases and the following search terms: (schizophrenia OR antipsychotic OR neuroleptic) AND (osteoporosis OR hyperprolactinaemia OR bone mineral density).Results-The available data indicates that statistically significant reductions in bone mineral density are frequently seen in patients prescribed antipsychotic medications and suggests that there is a higher incidence of clinically significant reductions compared with the normal population.Conclusions-Clinicians should be aware for the potential negative effects of antipsychotic medications on bone mineral density, particularly in patients with additional risk factors for osteoporosis. Recommendations regarding routine monitoring of bone mineral density for patients prescribed antipsychotic medications cannot be made on the basis of existing evidence and more research is required. Is antipsychotic treatment linked to low bone mineral density and osteoporosis? A review of the evidence and the clinical implications

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“…Hypogonadism assessment showed that six out of ten patients with craniopharyngioma were accompanied with hypogonadism. Vartej et al found that the document of fracture history and conventional roentgenograms indicated that hypogonadism was associated with significant bone loss [13]. Another possibility is insufficient sex steroid supplementation.…”

Section: Discussionmentioning

confidence: 98%