Effects of Hypertension on Abdominal Wall Healing: Experimental Study in Rats

Tostes, Jair Morais; Watanabe, André Luís Conde; Watanabe, Luís Massaro

doi:10.1007/s00595-006-3368-5

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…The abdominal wound healing has not been influenced The pressure level of hypertensive rats in this experiment was lower than that observed in the literature 14,17,20 . This difference in value was probably due to the fact that they were obtained in anesthetized rats rather other authors that had obtained it with the conscious rats.…”

Section: Discussioncontrasting

confidence: 60%

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Influence of arterial hypertension on colonic healing in rats

Ortolan¹,

Biondo-Simões

Fávero³

et al. 2012

Acta Cir. Bras.

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PURPOSE: Evaluation of colonic healing in spontaneously hypertensive rats. METHODS:Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group. Colotomy and bowel suture at 2.5 cm from the peritoneal reflection were performed. All animals were allocated randomly into sub-groups for review at the third, seventh and fourteenth days after surgery.We evaluated the concentration of angiotensin II, the burst pressure, epithelialization, the organization of the tunics of the bowel wall, inflammatory response and collagen deposition. RESULTS:The burst pressure, epithelialization, organization of the tunics and collagen deposition was not significant between groups.The inflammatory reaction was more intense in the control group on the third postoperative day (p=0.023) as the experimental group on the remaining time.CONCLUSION: Systemic arterial hypertension in rats did not influence significantly the healing process of colonic anastomoses.Key words: Wound Healing. Colon. Hypertension. Rats, Inbred SHR. RESUMO OBJETIVO:Avaliar a cicatrização colônica em ratos espontaneamente hipertensos. MÉTODOS:Cinquenta ratos machos, jovens e isogênicos. Vinte e cinco ratos da linhagem Wistar Kyoto (WKY) como controle e vinte e cinco ratos espontaneamente hipertensos (SHR) como grupo experimento. Realizou-se colotomia e colorrafia a 2,5 cm da reflexão peritoneal. Alocaram-se os animais aleatoriamente em sub-grupos para avaliação no terceiro, sétimo e décimo quarto dias de pós-operatório. Foram avaliados a concentração de angiotensina II, a resistência da anastomose à insuflação, a epitelização, a organização das túnicas da parede intestinal, a reação inflamatória e a deposição de colágeno. RESULTADOS:A avaliação da resistência da anastomose, epitelização, organização das túnicas e deposição de colágeno não foi significativa entre os grupos. A reação inflamatória foi mais intensa no grupo controle na avaliação do terceiro dia de pós-operatório (p=0,023) igualando-se ao grupo experimento nos demais tempos. CONCLUSÃO:A hipertensão arterial sistêmica, em ratos, não influenciou de forma significante no processo cicatricial de anastomoses do cólon.Descritores: Cicatrização. Cólon. Hipertensão. Ratos Endogâmicos SHR.

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Section: Discussioncontrasting

confidence: 60%

“…Tostes et al 17 measured the concentration of hydroxyproline in the abdominal wall of SHR rats subjected to laparotomy, obtaining the progressive concentration of hydroxyproline, which is a good marker of the amount of collagen in tissue 36 , on the seventh and fourteenth day after surgery.…”

mentioning

confidence: 99%

Influence of arterial hypertension on colonic healing in rats

Ortolan¹,

Biondo-Simões

Fávero³

et al. 2012

Acta Cir. Bras.

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“…Enalapril (40 mg/kg/day) or nifedipine (30 mg/kg/day) were administered orally every day for 3 weeks. The dosage and duration of administration were calculated considering the maximum therapeutic dose in humans and based on previous studies (8,9).…”

Section: Administration Of Antihypertensive Drugs In Wky and Shrmentioning

confidence: 99%

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

Lee

Kang

et al. 2012

International Journal of Molecular Medicine

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Enalapril and nifedipine are used as antihypertensive drugs; however, the therapeutic target molecules regulated by enalapril and nifedipine have yet to be fully identified. The aim of this study was to identify novel target genes that are specifically regulated by enalapril and nifedipine in tissues from spontaneously hypertensive rats (SHR) using DNA microarray analysis. We found that administration of SHR with enalapril and nifedipine differentially regulated 33 genes involved in the pathogenesis of cardiovascular diseases. Furthermore, we identified 16 genes that have not previously been implicated in cardiovascular diseases, including interleukin-24 (IL-24). Among them, exogenous administration of IL-24 attenuated the expression of vascular inflammation and hypertension-related genes induced by H2O2 treatment in mouse vascular smooth muscle (MOVAS) cells. This study provides valuable information for the development of novel antihypertensive drugs. In addition, the genes identified may be of use as biomarkers and therapeutic targets for cardiovascular diseases, including hypertension.

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“…The effect of hypertension on wound healing outcomes has been observed in clinical settings, where non-responsive wounds were more likely to be hypertensive compared to responsive wounds [ 16 ]. Furthermore, the effects of hypertension on abdominal wall healing have been studied, with untreated hypertension surprisingly not impairing indicators of wound healing in abdominal wounds [ 17 ]. In the context of chronic wounds, such as venous leg ulcers, hypertension plays a role in the healing process.…”

Section: Introductionmentioning

confidence: 99%

One Molecule, Many Faces: Repositioning Cardiovascular Agents for Advanced Wound Healing

Gościniak,

Stasiłowicz-Krzemień,

Michniak-Kohn

et al. 2024

Molecules

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Chronic wound treatments pose a challenge for healthcare worldwide, particularly for the people in developed countries. Chronic wounds significantly impair quality of life, especially among the elderly. Current research is devoted to novel approaches to wound care by repositioning cardiovascular agents for topical wound treatment. The emerging field of medicinal products’ repurposing, which involves redirecting existing pharmaceuticals to new therapeutic uses, is a promising strategy. Recent studies suggest that medicinal products such as sartans, beta-blockers, and statins have unexplored potential, exhibiting multifaceted pharmacological properties that extend beyond their primary indications. The purpose of this review is to analyze the current state of knowledge on the repositioning of cardiovascular agents’ use and their molecular mechanisms in the context of wound healing.

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Effects of Hypertension on Abdominal Wall Healing: Experimental Study in Rats

Abstract: Untreated hypertension had no effect on the abdominal wall healing of rats. Hypertensive animals treated with enalapril showed a significant decrease in abdominal wound-breaking strength on the 7th postoperative day.

Cited by 4 publications

References 26 publications

Influence of arterial hypertension on colonic healing in rats

Influence of arterial hypertension on colonic healing in rats

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

One Molecule, Many Faces: Repositioning Cardiovascular Agents for Advanced Wound Healing

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