1984
DOI: 10.1055/s-2007-1014870
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Effects of Hypophysectomy and Subsequent Growth Hormone Replacement in the Rat on the Ability of Serum to Stimulate Proliferation of Human and Mouse (BALB/c 3T3) Fibroblasts

Abstract: The ability of cultured human fibroblasts to synthesize and secrete a mitogenic, somatomedin C-like peptide suggests that human fibroblasts unlike certain other cell lines may not require exogenous somatomedin for cell proliferation. The aim of this study was to examine the effects of hypophysectomy and subsequent growth hormone (GH) replacement on the ability of rat serum to stimulate proliferation and DNA synthesis in cultured human fetal skin fibroblasts. For comparison we have also examined the effects of … Show more

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Cited by 3 publications
(1 citation statement)
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“…Serum from hypophysectomized animals stimulated fibroblast proliferation "in vitro," suggesting 54 CHAPTER 3 that hypophysectomy removes a specific inhibitor of fibroblast growth (Olsen et af.. 1979;Murphy and Lazarus, 1984). Supplementing primary cultures of rat S-V cells with sera from hypophysectomized pigs stimulated total cell proliferation but significantly reduced preadipocyte replication (Ramsay et al .. 1987a).…”
Section: Growth Hormonementioning
confidence: 99%
“…Serum from hypophysectomized animals stimulated fibroblast proliferation "in vitro," suggesting 54 CHAPTER 3 that hypophysectomy removes a specific inhibitor of fibroblast growth (Olsen et af.. 1979;Murphy and Lazarus, 1984). Supplementing primary cultures of rat S-V cells with sera from hypophysectomized pigs stimulated total cell proliferation but significantly reduced preadipocyte replication (Ramsay et al .. 1987a).…”
Section: Growth Hormonementioning
confidence: 99%