Effects of <i>Aronia melanocarpa</i> juice on plasma and liver phospholipid fatty acid composition in Wistar rats

Zec, Manja; Martačić, Jasmina Debeljak; Ranković, Slavica; Pokimica, Biljana; Tomić, Miloš; Ignjatović, Đurđica; Glibetić, Maria; Popović, Tamara

doi:10.1515/acve-2017-0010

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…Previous studies conducted with polyphenol containing juices have already indicated the occurrence of changes in the PPFA composition and thus, the daily consumption of a pomegranate juice rich in ANCs (among other polyphenols) for six weeks also increased the proportion of SFA and reduced the n-6 PUFA (AA) in the PPFA in women with metabolic syndrome [65], supporting our results. Nevertheless, other published reports give evidence of variability in the effects and, for example, the same chokeberry juices used in our study caused different changes in the PPFA composition in a rat model [19] and a similar chokeberry juice to the one used in our study (containing ~600 mg/100 mL of polyphenols) had an overall weak impact on the serum phospholipid composition of young sportive subjects [40]. Additionally, in humans, a polyphenol-rich chokeberry juice [21] and a glucomannan-enriched chokeberry drink [42] significantly altered the FA composition of the erythrocytes membranes.…”

Section: Discussionmentioning

confidence: 63%

“…An additional intervention drink was produced by dilution of the AMJ with the PLB (ratio 1:3) (AMJ d ). The final total polyphenol content of the drinks was determined by the Folin-Ciocalteu method and reported to be 1177.11 (AMJ, high-dose) and 294.28 (diluted AMJ d , low-dose) mg of GAE/100 mL [19]. The content of total cyanidin-3-glucoside equivalents as determined by the pH differential method [20] was 113.3 mg/100 mL and 28.3 mg/100 mL in the AMJ and AMJd, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk

et al. 2019

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Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the placebo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition.

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Section: Discussionmentioning

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk

et al. 2019

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“…The MJ was prepared as a 25% (v/v) solution of AJ in PLB. Total polyphenol contents of AJ and MJ were previously estimated by the Folin-Ciocalteu method and expressed as gallic acid equivalents [31]. A detailed composition of the AJ is available elsewhere [30].…”

Section: Ethical Clearance Study Design and Intervention Treatmentsmentioning

confidence: 99%

Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?

et al. 2021

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Dietary polyphenols promote cardiometabolic health and are linked with long-chain polyunsaturated fatty acids in plasma phospholipids (LC-PUFA). The FADS2 polymorphisms are associated with LC-PUFA metabolism and overweight/obesity. This 4-week study examined the link between polyphenol intake, FADS2 variants (rs174593, rs174616, rs174576) and obesity in 62 overweight adults (BMI ≥ 25), allocated to consume 100 mL daily of either: Aronia juice, a rich source of polyphenols, with 1177.11 mg polyphenols (expressed as gallic acid equivalents)/100 mL (AJ, n = 22), Aronia juice with 294.28 mg polyphenols/100 mL (MJ, n = 20), or nutritionally matched polyphenol-lacking placebo as a control (PLB, n = 20). We analyzed LC-PUFA (% of total pool) by gas chromatography and FADS2 variants by real-time PCR. Four-week changes in LC-PUFA, BMI, and body weight were included in statistical models, controlling for gender and PUFA intake. Only upon AJ and MJ, the presence of FADS2 variant alleles affected changes in linoleic, arachidonic, and eicosapentaenoic acid (EPA). Upon MJ treatment, changes in EPA were inversely linked with changes in BMI (β= −0.73, p = 0.029) and weight gain (β= −2.17, p = 0.024). Only in subjects drinking AJ, the link between changes in EPA and anthropometric indices was modified by the rs174576 variant allele. Our results indicate the interaction between FADS2, fatty acid metabolism, and polyphenol intake in overweight subjects.

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“…At this moment, there is still not enough scientific data to set recommendations for optimal dietary intake (Olas, 2018;Fraga, Croft, Kennedy & Tomás-Barberán, 2019). However, dose-dependent effects of polyphenols have been reported in numerous studies (Frejnagel & Juskiewicz, 2011;Murakami, 2014;Ounnas et al, 2017;Zec et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Lactate content, total polyphenols and antioxidant activity of selected commercial yogurts from the Serbian market

Pokimica¹,

Petrović-Oggiano²,

Šarac³

et al. 2022

Food & Feed Res

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One of the most popular dairy products worldwide is yogurt, which flavor is highly influenced by lactic acid content. Yogurts with fruit preparations contain polyphenols, secondary plant metabolites with proven antioxidant properties. As there is no data regarding neither lactate nor polyphenol content in commercial yogurts in Serbia, this study aimed to determine lactate and polyphenol levels, as well as antioxidant activity in selected yogurts. A total of 15 plain and 5 fruit yogurts with strawberry preparations were analyzed. Lactate contents were from 0.83 to 1.33%. Three plain yogurts in plastic containers differed in lactate content. There was no difference in lactate content among the same plain yogurts packed in plastic and Tetra Pack containers. Fruit yogurts with strawberry preparations differed in total polyphenol content in the range from 6.84 to 29.11mg GAE/100 g and antioxidant properties were determined by reducing power test (from 0.22 to 0.79) and DPPH assay (from 28.13 to 87.23%), while there was no difference regarding lactate. Our results provided new information about the levels of lactate, total polyphenols and antioxidant activity of selected commercial yogurts available on the Serbian market.

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Effects of Aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in Wistar rats

Cited by 7 publications

References 35 publications

Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk

Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk

Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?

Lactate content, total polyphenols and antioxidant activity of selected commercial yogurts from the Serbian market

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