Effects of <i>Bifidobacterium Lactis</i> BS01 and <i>Lactobacillus Acidophilus</i> LA02 on cognitive functioning in healthy women

Czajeczny, Dominik; Kabzińska, Karolina; Wójciak, R.W.

doi:10.1080/23279095.2021.1967155

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…In our review of the literature, we found that probiotic/prebiotic/symbiotic supplementation, administered for a minimum of 4 weeks (up to a maximum of 6 months), resulted in a significant improvement ( p < 0.05) in cognitive performance among healthy aging individuals (over 60 years old) (see Table 2 ). This improvement was observed in various domains, including memory, attention, and visuospatial/constructional abilities [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. However, one study [ 27 ] did not find a significant improvement in cognitive performance due to probiotic supplementation, specifically in seniors (average age 64.3 years) who were physically active and met recommended exercise guidelines.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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Recent research exploring the relationship between the gut and the brain suggests that the condition of the gut microbiota can influence cognitive health. A well-balanced gut microbiota may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, and symbiotics are nutritional supplements and functional food components associated with gastrointestinal well-being. The bidirectional communication of the gut–brain axis is essential for maintaining homeostasis, with pre-, pro-, and symbiotics potentially affecting various cognitive functions such as attention, perception, and memory. Numerous studies have consistently shown that incorporating pre-, pro-, and symbiotics into a healthy diet can lead to improvements in cognitive functions and mood. Maintaining a healthy gut microbiota can support optimal cognitive function, which is crucial for disease prevention in our fast-paced, Westernized society. Our results indicate cognitive benefits in healthy older individuals with probiotic supplementation but not in healthy older individuals who have good and adequate levels of physical activity. Additionally, it appears that there are cognitive benefits in patients with mild cognitive impairment and Alzheimer’s disease, while mixed results seem to arise in younger and healthier individuals. However, it is important to acknowledge that individual responses may vary, and the use of these dietary supplements should be tailored to each individual’s unique health circumstances and needs.

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Section: Resultsmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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“…Both the probiotic and the placebo will be administered after breakfast for ten weeks under identical conditions. The probiotic strains selected have shown to be effective in similar populations or in cognitive function (Agahi et al, 2018; Czajeczny et al, 2021; Kelly et al, 2017; Mehrabadi & Sadr, 2020; Oh et al, 2020; Patel et al, 2020; Sanborn et al, 2020; Yang et al, 2020), and the time duration has been predicted based on previous studies exploring the influence of probiotics on cognitive and emotional functions (Ruiz‐Gonzalez et al, 2021). Assessments will be conducted in three stages: at the start of the trial, following the intervention (10 weeks), and at study end (20 weeks).…”

Section: Methodsmentioning

confidence: 99%

Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial

Ruiz‐González

Cardona

Rodriguez‐Arrastia

et al. 2022

Research in Nursing & Health

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Ageing is a process that includes changes in cognitive and emotional functions, as well as changes in the diversity and integrity of gut microbiota. Probiotic treatments have recently been studied as a potential new therapeutic approach to alleviate a wide range of problems in other populations; however, clinical studies in older adults remain insufficient and limited. Thus, the aim of this project is to evaluate the efficacy of a multispecies probiotic formulation as a therapeutic strategy for attenuating the emotional and cognitive decline associated with ageing in adults over the age of 55. This is a doubleblind randomised placebo-controlled crossover trial involving at least 32 older adults and comparing two conditions: (a) probiotic, providing a multi-species probiotic for 10 weeks (Lactobacillus rhamnosus and Bifidobacterium lactis); and (b) placebo, receiving a harmless substance (potato starch). Despite the increasing use of probiotics for the treatment of cognitive and emotional problems, no study has yet focused on this group, to the best of our knowledge. Therapeutic strategies of the kind outlined in this protocol will help to shed light on the current state of knowledge about this topic, as well as promote health programs tailored to this population, which would encourage active ageing and healthy lifestyles. Not only do we expect improvements in the emotional dimension in terms of anxiety, stress, depression, and sleep quality, we also expect improvements in the cognitive dimension in terms of attention, memory, and decreased impulsivity.

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Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double‐Blind Randomized Placebo‐Controlled Crossover Trial

Ruiz-Gonzalez,

Cardona,

Rueda-Ruzafa

et al. 2024

Probiotics & Antimicro. Prot.

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As the population ages, cognitive decline becomes more common. Strategies targeting the gut-brain axis using probiotics are emerging to achieve improvements in neuropsychiatric and neurological disorders. However, the beneficial role of probiotics on brain function in healthy older adults remains unclear. Our aim was to evaluate a multi-species probiotic formulation as a therapeutic approach to reduce emotional and cognitive decline associated with aging in healthy adults. A randomized double-blind placebo-controlled crossover trial was conducted. The study involved a 10-week intervention where participants consumed the assigned probiotic product daily, followed by a 4-week washout period before the second condition started. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Psychological Experiments Construction Language Test Battery. At the emotional level, the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) were used. Thirty-three participants, recruited between July 2020 and April 2022, ingested a multispecies probiotic (Lactobacillus rhamnosus and Bifidobacterium lactis). After the intervention, noticeable enhancements were observed in cognitive function (mean difference 1.90, 95% CI 1.09 to 2.70, p < 0.005), memory (mean difference 4.60, 95% CI 2.91 to 6.29, p < 0.005) by MMSE and digit task, and depressive symptoms (mean difference 4.09, 95% CI 1.70 to 6.48, p < 0.005) by BDI. Furthermore, there were significant improvements observed in planning and problem-solving skills, selective attention, cognitive flexibility, impulsivity, and inhibitory ability. Probiotics administration improved cognitive and emotional function in older adults. Limited research supports this, requiring more scientific evidence for probiotics as an effective therapy for cognitive decline. This study has been prospectively registered at ClinicalTrials.gov (NCT04828421; 2020/July/17).

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Effects of Bifidobacterium Lactis BS01 and Lactobacillus Acidophilus LA02 on cognitive functioning in healthy women

Cited by 5 publications

References 42 publications

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial

Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double‐Blind Randomized Placebo‐Controlled Crossover Trial

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