Effects of cis -Dichlorodiammineplatinum (II) and Related Transition Metal Complexes on Escherichia coli

Abstract

A number of transition metal complexes, including the cis and trans isomers of dichlorodiammineplatinum (II), six complexes of rhodium (I), two of iridium (I), and one of ruthenium (II) have been tested for their ability to induce lambda prophage, to produce filamentous growth of Escherichia coli , and to be selectively toxic for strains with defects in the deoxyribonucleic acid repair system. Dichlorotetrakis(dimethylsulfoxide)ruthenium II [RuCl 2 (DMSO) 4 ] was strictly similar to cis -dichlorodiammineplatinum II [ cis PtCl 2 (NH 3 ) 2 ] in the test for lambda induction, filamentous growth production, and selective toxicity for a recA − strain. [Rh COD 1,10-phenanthroline] + Cl − , though more toxic for recA − than for rec + E. coli , was scarcely effective in the test for filamentous growth and did not induce prophage. None of the other tested compounds showed any similarity with cis -PtCl 2 (NH 3 ) 2 . Due to the interesting results obtained with cis -PtCl 2 (NH 3 ) 2 as an antitumor agent, it seems reasonable to propose RuCl 2 (DMSO) 4 as a potential antitumor substance.

Metal Complexes with Aromatic N-Containing Ligands as Potential Agents in Cancer Treatment

“…Figure (14) shows the structures of NAMI-A and other Ru(III) antitumor complexes with N-donor heterocycle ligands. These Ru(III) compounds exhibit the best antitumor and antimetastatic activity in all tested ruthenium complexes [12,98]. Since metastatic cancer is particularly difficult to treat, the antimetastatic activity of the ruthenium DMSO complexes particularly NAMI-A represents an important development.…”

Kinetics and mechanism of the reaction of hydroxopentaaquarhodium(III) ion with l-Arginine in aqueous solution

“…Other platinum metals also show similar properties [3,4] of which ruthenium complexes can be an order of magnitude less toxic than Cis-platin [5,6]. The biological activities of a series of complexes of ruthenium, osmium, rhodium, and iridium bearing the ligands Cl -, H 2 O, and Cl -, NH 3 and Cl -, Me 2 SO and Cl -, pyridine and Cl -have been reported [7][8][9].…”

Kinetic and mechanistic studies on the interaction of thymidine with the hydroxopentaaquarhodium(III) ion

“…In general, ruthenium complexes are an order of magnitude less toxic than cis-platin [10,11]. The biological activity of a series of rare platinum complexes of ruthenium, osmium, rhodium and iridium bearing the ligands Cl ) , H 2 O and Cl ) , NH 3 and Cl ) , Me 2 SO and Cl ) , pyridine and Cl ) has also been reported [12][13][14].…”