Effects of<i>Glycyrrhizae Radix</i>on Repeated Restraint Stress-induced Neurochemical and Behavioral Responses

Park, Hyun-Jung; Shim, Hyun Soo; Kim, Sujeong; Kim, Kyung Soo; Lee, Hyejung; Hahm, Dae‐Hyun; Shim, Insop

doi:10.4196/kjpp.2010.14.6.371

Cited by 38 publications

(27 citation statements)

References 28 publications

(30 reference statements)

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“…increases in CRF immunoreactivity in the PVN but significantly decreased TH-like immunoreactivity in the LC. The TH enzyme is an important player in the stressinduced activation of the CNS and in stress-related psychopathological conditions, including anxiety (Park et al 2010). Therefore, the administration of EPT may regulate increases in anxiolytic-like behaviors in the EPM and OFT via the increased expression of TH in the LC, which is consistent with previous studies (Park et al 2010).…”

Section: Discussionsupporting

confidence: 84%

“…The TH enzyme is an important player in the stressinduced activation of the CNS and in stress-related psychopathological conditions, including anxiety (Park et al 2010). Therefore, the administration of EPT may regulate increases in anxiolytic-like behaviors in the EPM and OFT via the increased expression of TH in the LC, which is consistent with previous studies (Park et al 2010). Together, the present findings suggest that EPT attenuated the behaviors and neurochemical responses associated with anxiety by modulating the HPA axis and the central noradrenergic system.…”

Section: Discussionmentioning

confidence: 99%

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Polygala tenuifoliaprevents anxiety-like behaviors in mice exposed to repeated restraint stress

Lee

Sur

Shin

et al. 2014

Animal Cells and Systems

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The pathophysiology underlying anxiety disorders involves stress and associated increases in glucocorticoid levels in the blood. The present study investigated the effects of the administration of the crude extract of Polygala tenuifolia (EPT) on repeated restraint stress-induced anxiety-like behavioral responses in mice. Additionally, possible changes in the central noradrenergic and brain-derived neurotrophic factor (BDNF)-signaling systems were assessed in the hippocampus of these mice. For 14 consecutive days, mice were orally administrated EPT (50 or 250 mg/kg) 30 min prior to the restraint stress procedure (2 h/day). Dysregulation within the hypothalamic-pituitary-adrenal (HPA) axis in response to the repeated restraint stress was confirmed by measuring serum levels of corticosterone and the expression of corticotrophin-releasing factor in the hypothalamus. Compared with control subjects, the daily administration of higher doses of EPT (250 mg/kg) increased open-arm exploration in an elevated plus maze and the total number of line crossings in an open-field test. EPT also reversed the increased expression of tyrosine hydroxylase in the locus coeruleus and the decreased expression of BDNF mRNA in the hippocampus. Together, these findings demonstrate that the administration of EPT prior to repeated restraint stress significantly reduced anxiety-like behaviors in mice. These changes were associated with a modification of the central noradrenergic system and the upregulation of BDNF expression, which in turn attenuated activity in the HPA axis.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Polygala tenuifoliaprevents anxiety-like behaviors in mice exposed to repeated restraint stress

Lee

Sur

Shin

et al. 2014

Animal Cells and Systems

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“…This may have led to decrease in the number of arm entries in Y-maze test. This assumption is supported by published data (Park et al, 2010), although some studies showed an inverse relationship between avoidance and long-term spatial memory (He et al, 2011). The paradoxical stimulating effect of the irradiation on object recognition in 36Gy/6 group can also be associated with increased anxiety in this group.…”

Section: Discussionsupporting

confidence: 77%

Radiation-Induced Cognitive Dysfunction After Different Schemes of Fractionated Whole Brain Irradiation

Alexandrovna¹,

Andreevich²,

Maratovna³

et al. 2014

American Journal of Neuroscience

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Radiation-induced cognitive dysfunction is a serious complication of radiation therapy. In humans, numerous cases of radiation damage have been recorded after irradiation for therapeutic purposes. The degree of cognitive dysfunctions and its dependence on biological effective doses should be tested in animal preclinical models to minimize radiation side effects. Fractionated whole brain irradiation was performed according to the following schemes: 18 Fractions of 2 Gy each (36Gy/18), 9 fractions of 4 Gy each (36Gy/9), 6 fractions of 6 Gy each (36Gy/6), with the biological effective dose 36Gy, 50.4Gy, 64.8Gy correspondingly. Cognitive impairment was detected by a Novel object recognition test in 36Gy/18 and 36Gy/9 groups. Recognition memory impairment was increased in inverse proportion to the biological effective dose. In the 36Gy/6 group, increased anxiety and decreased research activity in Spontaneous alternation test in Y-shaped maze were observed. Reactions of astroglia and vascular reactions were evaluated using qPCR of Glial Fibrillar Acid Protein (GFAP) and Vascular Endothelial Growth Factor (VEGF) genes and immunohistochemical analyses of these proteins. Despite of various biological effective doses (and its subsequent increasing in chosen 3 fractionation schemes) a dose-depended effect in the expression of VEGF in the prefrontal cortex and GFAP in hippocampus and in cognitive impairment was not observed. Cognitive impairment after fractionated whole brain irradiation was clearly seen in our research. The described pathologic changes in healthy brain play an important role in development of radiation-induced cognitive dysfunction. Therefore, applicability of radiobiological models for evaluation of effects of fractionated whole brain irradiation on cognitive dysfunction put in question in our study. So we can suggest that it needs essential more researches about the choice an optimal fractionated scheme to minimize side effects of ionizing radiation.

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“…Activation of the LC produces intense anxiety, hypervigilance and inhibition of exploratory behavior [24,25]. It has been proposed that clinical anxiety or depression may be the result of alterations in the activity of the LC in central noradrenergic system [26]. Thus, our results suggest that the central adrenergic system is involved in the antidepressant effect of BER on despair-like behavior that persisted for 3 days in rats following withdrawal from repeated morphine administration.…”

Section: Discussionmentioning

confidence: 55%

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Lee

Sur

Yeom

et al. 2012

Korean J Physiol Pharmacol

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The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression-and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic morphine withdrawal in rats. Male rats were exposed to chronic, intermittent, escalating morphine (10∼ 50 mg/kg) for 10 days. After the last morphine injection, depression-and anxiety-like beahvior associated with morphine discontinuation persisted for at least three days during withdrawal without any change in ambulatory activity. Daily BER administration significantly decreased immobility in the forced swimming test and increased open-arm exploration in the elevated plus maze test. BER administration also significantly blocked the increase in hypothalamic CRF expression and TH expression in the locus coeruleus (LC) and the decrease in hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression. Taken together, these findings demonstrated that BER administration significantly reduced morphine withdrawal-associated behaviors following discontinuation of repeated morphine administration in rats, possibly through modulation of hypothalamic CRF and the central noradrenergic system. BER may be a useful agent for treating or alleviating complex withdrawal symptoms and preventing morphine use relapses.

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Effects ofGlycyrrhizae Radixon Repeated Restraint Stress-induced Neurochemical and Behavioral Responses

Cited by 38 publications

References 28 publications

Polygala tenuifoliaprevents anxiety-like behaviors in mice exposed to repeated restraint stress

Polygala tenuifoliaprevents anxiety-like behaviors in mice exposed to repeated restraint stress

Radiation-Induced Cognitive Dysfunction After Different Schemes of Fractionated Whole Brain Irradiation

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

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