Effects of <i>Hippeastrum reticulatum</i> on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease

Hoang, Trang Huyen Xuan; Ho, Duc Viet; Phan, Kiem Van; Le, Quan Van; Raal, Ain; Nguyen, Hoai Thi

doi:10.1080/13880209.2020.1841810

Cited by 17 publications

(16 citation statements)

References 21 publications

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“…In this review, seventeen articles were found to contain the alkaloid profile of twenty-three Hippeastrum extracts (Table S1 ) published between 2012 and 2021 (de Andrade et al 2014 ; Carvalho et al 2015 ; Cortes et al 2015a , b ; Sebben et al 2015 ; Guo et al 2016 ; Ortiz et al 2016 ; Bessa et al 2017 ; Tallini et al 2017 ; Shammari et al 2019 ; Gasca et al 2020 ; Hoang et al 2020 ; Lianza et al 2020 ; Feu et al 2021 ; Paiva et al 2021 ; Shammari et al 2021 ; Souza et al 2021 ). Twelve species were collected in Brazil, two in Colombia, one in Argentina, one in Vietnam, and all the Hippeastrum cultivars were from the Czech Republic (Table S2 ).…”

Section: Discussionmentioning

confidence: 99%

Structural Diversity and Biological Potential of Alkaloids from the Genus Hippeastrum, Amaryllidaceae: an Update

Tallini

Giordani

Andrade

et al. 2021

Rev. Bras. Farmacogn.

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Graphical abstract The subfamily Amaryllidoideae, Amaryllidaceae, presents an exclusive group of structures known as Amaryllidaceae alkaloids, which have a broad spectrum of biological activities. These plants are classified into 59 genera, including Hippeastrum Herb., which comprises approximately 60 species distributed mainly in South America, being widely used as ornamental plants due to the beauty of its flowers. This review presents an update about the alkaloid profiling of Hippeastrum extracts published between 2012 and 2021, as well as an approach to the biological potential of these compounds. Supplementary Information The online version contains supplementary material available at 10.1007/s43450-021-00211-z.

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Section: Discussionmentioning

confidence: 99%

Structural Diversity and Biological Potential of Alkaloids from the Genus Hippeastrum, Amaryllidaceae: an Update

Tallini

Giordani

Andrade

et al. 2021

Rev. Bras. Farmacogn.

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“…Consistent with our ndings, some previous investigations have also reported the cognition-impairing effects of scopolamine using behavioral tests (Marefati et al 2019;Brinza et al 2021). Accordingly, Hoang showed that the mean latencies and swimming distances increased by the administration of scopolamine (Hoang et al 2020). Additionally, scopolamine reduced the latency to enter the darkness after shock (Ishola et al 2020).…”

Section: Discussionmentioning

confidence: 99%

“…30 min before administrating scopolamine (i.p.). In groups II-VI, a single dose of scopolamine was administered 30 min before conducting each trial in the behavioral tests (Ghasemi et al 2019;Marefati et al 2019;Brinza et al 2021;Hoang et al 2020).…”

Section: Drug Administration and Experimental Designmentioning

confidence: 99%

Effect of Sanguisorba Minor on Scopolamine-induced Memory Loss in Rat: Involvement of Oxidative Stress and Acetylcholinesterase

Hosseini¹,

Mansouritorghabeh²,

Kakhki³

et al. 2021

Preprint

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Sanguisorba minor (S. minor) has neuroprotective and antioxidant activities; nevertheless, its potential benefits in ameliorating learning and memory functions have not been explored yet. So, in this study, rats were treated with S. minor hydro-ethanolic extract (50, 100, and 200 mg/kg, intraperitoneal (i.p.)) as well as rivastigmine (0.5 mg/kg, i.p.) for 21 consecutive days. Thereafter, their behavioral performance was assessed using Morris water maze (MWM) and passive avoidance (PA) tasks. Scopolamine was also injected 30 min before conducting the tasks. Finally, oxidative stress biomarkers and acetyl cholinesterase (AChE) activity were determined in the brain. The extract characterization was presented using liquid chromatography-mass spectrometry (LC-MS), which confirmed the presence of quercetin, myricetin, kaempferol, catechin, ellagic acid, and gallic acid derivatives. According to the results, the extract at all doses could significantly recover the impairment of cognitive performance of the scopolamine-treated rats. In the MWM test, the extract and rivastigmine reduced escape latency and travelled distance, compared to the scopolamine group. Moreover, in the PA test, the latency to enter the dark chamber was significantly increased by the extract and rivastigmine, compared to the scopolamine group (p<0.05-p<0.001). Similar to rivastigmine, the extract attenuated both AChE activity and oxidative injury in the brain as evidenced by the increased antioxidant enzymes and total thiol content, but it decreased malondialdehyde level (p<0.05-p<0.001). In conclusion, the results suggested the effectiveness of S. minor on preventing cognitive dysfunction induced by scopolamine. Accordingly, these protective effects might be produced through the regulation of cholinergic activity and oxidative stress.

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“…The alkaloidal extract of Hippeastrum reticulatum bulbs (AHR) has been studied for its ameliorating effects on memory and cognitive dysfunction in a scopolamine-induced rodent model of AD using a Y-maze, the novel object recognition test (NORT), and the Morris water maze (MWM) test [ 90 ]. Sixty Swiss male mice, divided into six groups, received samples for 15 days.…”

Section: Amaryllidaceae Alkaloidsmentioning

confidence: 99%

“…The results of in vivo studies showed that AHR (15 mg/kg) significantly increased spontaneous alternation performance in the Y-maze test, and significantly increased the time spent exploring the novel object compared with the scopolamine-treated group. In the MWM test, the administration of AHR at doses of 10 and 15 mg/kg significantly decreased escape latency and swimming distance to the platform, which indicates learning and spatial memory abilities of the mice [ 90 ].…”

Section: Amaryllidaceae Alkaloidsmentioning

confidence: 99%

Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease

et al. 2021

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Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is only symptomatic and available drugs are not able to modify AD progression. Considering the increase in life expectancy worldwide, AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. Due to their complex nitrogen-containing structures, alkaloids are considered to be promising candidates for use in the treatment of AD. Since the introduction of galanthamine as an antidementia drug in 2001, Amaryllidaceae alkaloids (AAs) and further isoquinoline alkaloids (IAs) have been one of the most studied groups of alkaloids. In the last few years, several compounds of new structure types have been isolated and evaluated for their biological activity connected with AD. The present review aims to comprehensively summarize recent progress on AAs and IAs since 2010 up to June 2021 as potential drugs for the treatment of AD.

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Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease

Cited by 17 publications

References 21 publications

Structural Diversity and Biological Potential of Alkaloids from the Genus Hippeastrum, Amaryllidaceae: an Update

Structural Diversity and Biological Potential of Alkaloids from the Genus Hippeastrum, Amaryllidaceae: an Update

Effect of Sanguisorba Minor on Scopolamine-induced Memory Loss in Rat: Involvement of Oxidative Stress and Acetylcholinesterase

Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease

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