Effects of<i>Houttuynia cordata</i>Extracts of Different Aerial Parts on Antioxidants and Anti-inflammatory

Lee, Sung‐Gyu; Kang, Hunseung

doi:10.15616/bsl.2018.24.2.87

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Since the collection in 2015, it has been planted and preserved in, with the same cultivation conditions and conventional water and fertilizer management as resource materials. In October 2018, the roots were dug out, and each material was planted in three repeated plots with an area of 4 × 2.5m 2…”

Section: Experimental Materialsmentioning

confidence: 99%

“…Decyl acetaldehyde, the main antibacterial active component of Houttuynia cordata Thunb, has an obvious antibacterial effect on a variety of bacteria, acid-fast bacilli and fungi, but its properties are unstable (1)(2)(3). The synthetic sodium bisulfite adduct of decanoylacetaldehyde in China is called synthetic houttuynin and has an obvious antibacterial effect on a variety of gram-positive and negative bacteria (4).…”

Section: Introductionmentioning

confidence: 99%

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Extraction and activity of chemical constituents from Houttuynia cordata Thunb by ultrasonic method

Song

Shen

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Polyphenols and flavonoids are phytochemicals that have essential roles in human nutrition. In this regard, the contents of polyphenols and flavonoids in Houttuynia cordata Thunb and their antioxidant activities were evaluated in the current study. Two Houttuynia cordata materials with the same chromosome number and chemical type were used to comprehensively assess the contents of total phenols and flavonoids in different parts of H. cordata. These chemical components were extracted by the ultrasonic method. The results showed that the total phenols and antioxidant capacity of different parts of H. cordata were significantly different. The content of polyphenols in roots and stems was low, the antioxidant capacity was weak, the total phenols in flowers and leaves were high, and the antioxidant capacity was strong. Therefore, different parts of H. cordata had different pharmacological and food effects. The whole herb can be used as Chinese herbal medicine, and its young leaves and roots can be used as vegetables. Flavonoids are the main phenolic components, and total phenols are the main components of antioxidant activity. It can explain a very significant positive correlation between total phenols and flavonoids. Therefore, in the further breeding work of H. cordata, the procedure can be simplified by determining one of the above indexes to predict the varieties with high total phenolic and antioxidant activity.

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Section: Experimental Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extraction and activity of chemical constituents from Houttuynia cordata Thunb by ultrasonic method

Song

Shen

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Antioxidant and Anti-Inflammatory Activities of Ethanol Extract of Clematis trichotoma Nakai

정재미

신미준

정나은

et al. 2021

Korean J Clin Lab Sci.

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Clematis trichotoma Nakai (CTN) is a broad-leaved vine plant belonging to the family Ranunculus, native to Korea. Young leaves are used as food, and the stem and roots are used as medicinal materials. Antioxidant studies have been reported on the stems of CTN, but no studies have been conducted on the leaves. In this study, a 70% ethanol extract of CTN was prepared and its antioxidant and anti-inflammatory activities were investigated. For measuring the antioxidant activity, five assays (polyphenol and flavonoid content, reducing power, 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity) were performed and CTN showed a concentration-dependent effect in all assays. To investigate the anti-inflammatory activity, we used RAW 264.7 cells. The concentrations (from 31.25 to 250 μg/mL) of CTN did not show cytotoxicity. CTN (250 μg/mL) inhibited dendritic transformation (34.4%) and also inhibited inflammation as seen by reduced levels of NO (77.4%), IL-6 (85.5%) and TNF-α (41.2%) compared to lipopolysaccharide (LPS). CTN (250 μg/mL) also suppressed the expression of the following genes: COX-2 (79.8%), iNOS2 (93.9%), IL-6 (87.6%), and TNF-α (77.3%) compared to LPS. These results demonstrated that CTN has excellent antioxidant and anti-inflammatory activities and can therefore be used as a natural biological resource.

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Houttuynia cordata Thunb. Attenuates Hepatic Lipid Accumulation in Diet-Induced Obese Mice

Cho

Kwon

2021

JKFN

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This study investigated the hepatic lipid-lowering effect of Houttuynia cordata Thunb. (HC) in high-fat diet-induced obese mice. Antioxidant activities were measured using ABTS and DPPH assays in 30% ethanol extract of HC. C57BL/6 mice were classified into five groups: Normal group; 60% high-fat diet group (Control); Control with garcinia cambogia 200 mg/kg/d group (GC200); Control with HC 100 mg/kg/d group (HC100); Control with HC 200 mg/kg/d group (HC200). The DPPH and ABTS free radical scavenging activities of HC extract were estimated to be high (27.90±0.39 and 60.35±1.65 µg/mL, respectively). The high-fat Control diet resulted in significantly increased body weight and liver and epididymal adipose tissue weights compared to Normal diet. Supplementation with GC200 or HC200 reduced body weight, and all three supplementations (GC200, HC100, and HC200) decreased liver weight. Moreover, HC200 lowered epididymal white adipose tissue weight. The three treatments significantly lowered serum triglyceride and total cholesterol (TC) levels. Especially, HC200 showed the strongest serum TC-lowering effect. HC200 also suppressed expression of hepatic lipogenesis proteins (NADPH oxidase 4 (NOX4), p47phox, p22phox, sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthesis (FAS), and stearoyl-CoA desaturase-1 (SCD-1)). As a result, hepatic lipids levels were lowered in the HC200 group. These results suggest that HC200 protects against hepatic lipid accumulation and has an anti-obesity effect.

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Effects ofHouttuynia cordataExtracts of Different Aerial Parts on Antioxidants and Anti-inflammatory

Cited by 3 publications

References 15 publications

Extraction and activity of chemical constituents from Houttuynia cordata Thunb by ultrasonic method

Extraction and activity of chemical constituents from Houttuynia cordata Thunb by ultrasonic method

Antioxidant and Anti-Inflammatory Activities of Ethanol Extract of Clematis trichotoma Nakai

Houttuynia cordata Thunb. Attenuates Hepatic Lipid Accumulation in Diet-Induced Obese Mice

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