Effects of <i>Hypericum montbretti</i> Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity

Can, Özgür Devrim; Özkay, Ümide Demir

doi:10.1002/ptr.4629

Cited by 20 publications

(16 citation statements)

References 42 publications

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“…Exploratory behavior of mice was screened using hole‐board tests (Ugo Basile, no. 6650, Varese, Italy), as described previously (Can et al ., ; Can and Ozkay, ). The total number of head‐dipping behavior was recorded for 5 min.…”

Section: Methodsmentioning

confidence: 97%

“…As well as Hypericum perforatum , the most well‐known medicinal plant belonging to this family, some other species such as Hypericum canariense , Hypericum glandulosum (Sánchez‐Mateo et al ., ), Hypericum caprifoliatum (Viana et al ., ), Hypericum enshiense (Wang et al ., ), and Hypericum montbretii (Can et al ., ), have been previously reported for their antidepressant activities. Furthermore, some Hypericum species, such H. montbretii (Can and Ozkay, ), H. perforatum , and Hypericum hircinum (Diana et al ., ), have been reported to have sedative activity in relation to the CNS. Another CNS‐related activity, centrally mediated antinociception, has been reported in rodents after administration of extracts of Hypericum grandifolium (Bonkanka et al ., ), H. caprifoliatum , Hypericum polyanthemum (Viana et al ., ), H. canariense , H. glandulosum (Rabanal et al ., ), and Hypericum reflexum (Sánchez‐Mateo et al ., ).…”

Section: Introductionmentioning

confidence: 99%

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Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Yaşar

Can

Öztürk

et al. 2012

Phytotherapy Research

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Pharmacological effects of hydroalcoholic extract prepared from Hypericum origanifolium Willd. (Guttiferae) on behavioral parameters and pain perceptions of mice were investigated in this study. Depression, anxiety, spontaneous locomotor activity, and motor coordination parameters of mice were assessed by modified forced swimming, hole board, activity cage, and rota-rod tests, respectively. In addition, antinociceptive effect was evaluated by performing hot-plate, tail-clip, and formalin tests. Reboxetine (20 mg/kg), diazepam (1 mg/kg), and morphine (10 mg/kg) were used as reference antidepressant, anxiolytic, and analgesic drugs, respectively. Phytochemical analyses exhibited that chlorogenic acid (2317.12 ppm) and rutin (2108.79 ppm) were the main phenolic compounds in the H. origanifolium extract. The extract (50, 100, and 250 mg/kg) induced significant antidepressant, anxiolytic, and antinociceptive activities following the acute administrations. Anxiolytic effect was antagonized by flumazenil (a benzodiazepine receptor antagonist, 2.5 mg/kg, i.p.) pre-treatment, which indicated the participation of GABA(A)-benzodiazepine receptor complex in the activity. Moreover, centrally and peripherally mediated antinociception reversed by naloxone (a non-selective opioid receptor antagonist, 5 mg/kg, i.p.) pre-treatment, indicating the involvement of opioid system in the pharmacological action. These findings are the first to indicate the pharmacological effects of the H. origanifolium extract on the emotional state and pain perceptions of mice.

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Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Yaşar

Can

Öztürk

et al. 2012

Phytotherapy Research

Self Cite

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“…Hypericum perforatum (HP), or St John's wort, is a plant whose extract, one of the best-characterised herbal medicines, is widely sold in health food stores and pharmacies in Europe and the USA (annual US sales increased from $20m in 1995 to $200m in 1997) for the treatment of depression (Lecrubier et al, 2002;Kasper et al, 2006). Preclinical studies on the central nervous system activity of HP extracts suggest that it also displays anxiolytic, sedative, nootropic, antischizophrenic, anticonvulsant, antidiabetic, and analgesic activities and that it may be beneficial in the treatment of alcohol, nicotine, and caffeine addiction in experimental animals (Can et al, 2011;Can and Ozkay, 2012).…”

Section: Introductionmentioning

confidence: 99%

Hypericum perforatum : Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug-Drug Interactions

et al. 2013

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Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest used and most extensively investigated medicinal herbs. The medicinal form comprises the leaves and flowering tops of which the primary ingredients of interest are naphthodianthrones, xanthones, flavonoids, phloroglucinols (e.g. hyperforin), and hypericin. Although several constituents elicit pharmacological effects that are consistent with HP's antidepressant activity, no single mechanism of action underlying these effects has thus far been found. Various clinical trials have shown that HP has a comparable antidepressant efficacy as some currently used antidepressant drugs in the treatment of mild/moderate depression. Interestingly, low-hyperforin-content preparations are effective in the treatment of depression. Moreover, HP is also used to treat certain forms of anxiety. However, HP can induce various cytochrome P450s isozymes and/or P-glycoprotein, of which many drugs are substrates and which are the main origin of HP-drug interactions. Here, we analyse the existing evidence describing the clinical consequence of HP-drug interactions. Although some of the reported interactions are based on findings from in vitro studies, the clinical importance of which remain to be demonstrated, others are based on case reports where causality can, in some cases, be determined to reveal clinically significant interactions that suggest caution, consideration, and disclosure of potential interactions prior to informed use of HP.

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“…used different behavioral methods, including the activity cage test and Hxb-induced sleep, to investigate the sedative activity of a methanol extract of H. montbretii containing rutin (1519 ppm) and quercitrin (784 ppm). This H. montbretii extract possessed sedative and anticonvulsant activities mediated via the GABA A -benzodiazepine (GABA A -BZD) receptor complex in the CNS of mice [27]. E. Ernst et al .…”

Section: Resultsmentioning

confidence: 99%

Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence

Shi¹,

Dong²,

Zhao³

et al. 2014

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Insomnia is a common sleep disorder which is prevalent in women and the elderly. Current insomnia drugs mainly target the γ-aminobutyric acid (GABA) receptor, melatonin receptor, histamine receptor, orexin, and serotonin receptor. GABAA receptor modulators are ordinarily used to manage insomnia, but they are known to affect sleep maintenance, including residual effects, tolerance, and dependence. In an effort to discover new drugs that relieve insomnia symptoms while avoiding side effects, numerous studies focusing on the neurotransmitter GABA and herbal medicines have been conducted. Traditional herbal medicines, such as Piper methysticum and the seed of Zizyphus jujuba Mill var. spinosa, have been widely reported to improve sleep and other mental disorders. These herbal medicines have been applied for many years in folk medicine, and extracts of these medicines have been used to study their pharmacological actions and mechanisms. Although effective and relatively safe, natural plant products have some side effects, such as hepatotoxicity and skin reactions effects of Piper methysticum. In addition, there are insufficient evidences to certify the safety of most traditional herbal medicine. In this review, we provide an overview of the current state of knowledge regarding a variety of natural plant products that are commonly used to treat insomnia to facilitate future studies.

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Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity

Cited by 20 publications

References 42 publications

Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

Hypericum perforatum : Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug-Drug Interactions

Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence

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