Effects of <i>Lonicera japonica</i>
 Thunb. on Type 2 Diabetes via PPAR-<i>γ</i>
 Activation in Rats

Han, Jae Min; Kim, Mi Hye; Choi, You Yeon; Lee, Haesu; Ji, Hong

doi:10.1002/ptr.5413

Cited by 32 publications

(13 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, PPARc agonists, such as pioglitazone and rosiglitazone, have been widely used as insulin sensitizers in the diabetes treatment [28]. In the current studies, plantderived compound extracts have been described to improve insulin sensitivity and promote adipocyte differentiation by activating PPARc [29][30][31]. Herein, we demonstrated for the first time that HEPa/EtOAc treatment increased the expression of PPARc in liver and with more intensity in adipose tissue.…”

Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 78%

“…HEPa/EtOAc treatment was able to improve the physiological parameters from obese mice, through the activation of PPARc per si, as well as the enhancement of antioxidant mechanism by an increase in PPARc/CuZn-SOD axis expression in liver and adipose tissue scientific community [24,25,31]. In this way, it has been demonstrated that compounds from plant sources can modulate nuclear receptors such as PPARs [29][30][31]47]. Additionally, several studies have suggested that the large fraction of flavonoids could be responsible for PPARc activation and consequently the cellular effects observed [47,48].…”

Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 93%

See 1 more Smart Citation

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

et al. 2016

View full text Add to dashboard Cite

Parkinsonia aculeata L. (Caesalpiniaceae) is a traditional ethnomedicine and has been used for the empiric treatment of hyperglycemia, without scientific background. Mechanistic analyses at molecular level from the antioxidant mechanism observed by P. aculeata are required. Herein the effects of the treatment by hydroethanolic extract partitioned with ethyl acetate of P. aculeata aerial parts (HEPa/EtOAc) in mice fed a high-fat diet that share many obesity phenotypes with humans were evaluated. The animals were treated orally with HEPa/EtOAc (125 and 250 mg/kg/day) and pioglitazone (5 mg/kg/day), for 16 days. After the treatment, HEPa/EtOAc reduced fasting serum glucose and insulin levels, as well as homeostasis model assessment for insulin resistance. In addition, an improvement in glucose intolerance was also observed. Indeed, a reduction in the circulating levels of TNF-α and IL-6 was also observed. Furthermore, at molecular level, it was demonstrated that the HEPa/EtOAc treatment was able to improve these physiological parameters, through the activation of peroxisome proliferator-activated receptor γ (PPARγ) per si, as well as the enhancement of antioxidant mechanism by an increase in PPARγ/Cu(2+), Zn(2+)-superoxide dismutase (CuZn-SOD) axis expression in liver and adipose tissue. In sum, P. aculeata is effective to improve insulin resistance in a mouse model of obesity and this effect seems to involve the antioxidant and anti-inflammatory mechanisms through the increase in PPARγ/CuZn-SOD axis expression.

show abstract

Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 78%

Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 93%

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The use of plants that contain these metabolites for the treatment of T2D has been reported in folk medicine [36,[45][46][47]. However, to the best of our knowledge, this is the first report regarding antidiabetic properties of compounds 26 and 29.…”

Section: Isolation and Pharmacological Evaluation Of The α-Glucosidasmentioning

confidence: 99%

High-Resolution α-Glucosidase Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of Antidiabetic Compounds in Eremanthus crotonoides (Asteraceae)

et al. 2016

View full text Add to dashboard Cite

α-Glucosidase inhibitors decrease the cleavage-and absorption rate of monosaccharides from complex dietary carbohydrates, and represent therefore an important class of drugs for management of type 2 diabetes. In this study, a defatted ethyl acetate extract of Eremanthus crotonoides leaves with an inhibitory concentration (IC 50 ) of 34.5 µg/mL towards α-glucosidase was investigated by high-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR. This led to identification of six α-glucosidase inhibitors, namely quercetin (16), trans-tiliroside (17), luteolin (19), quercetin-3-methyl ether (20), 3,5-di-O-caffeoylquinic acid n-butyl ester (26) and 4,5-di-O-caffeoylquinic acid n-butyl ester (29). In addition, nineteen other metabolites were identified. The most active compounds were the two regioisomeric di-O-caffeoylquinic acid derivatives 26 and 29, with IC 50 values of 5.93 and 5.20 µM, respectively. This is the first report of the α-glucosidase inhibitory activity of compounds 20, 26, and 29, and the findings support the important role of Eremanthus species as novel sources of new drugs and/or herbal remedies for treatment of type 2 diabetes.

show abstract

“…The regioisomers 3,5-di-O-caffeoylquinic acid n-butyl ester (26) and 4,5-di-O-caffeoylquinic acid n-butyl ester (29) showed the highest inhibitory effects in the α-glucosidase assay. The use of plants that contain these metabolites for the treatment of T2D has been reported in folk medicine [36,[45][46][47]. However, to the best of our knowledge, this is the first report regarding antidiabetic properties of compounds 26 and 29.…”

Section: Isolation and Pharmacological Evaluation Of The α-Glucosidasmentioning

confidence: 99%

High-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-diabetic compounds in Eremanthus crotonoides (Asteraceae)

et al. 2016

View full text Add to dashboard Cite

α-Glucosidase inhibitors decrease the cleavage-and absorption rate of monosaccharides from complex dietary carbohydrates, and represent therefore an important class of drugs for management of type 2 diabetes. In this study, a defatted ethyl acetate extract of Eremanthus crotonoides leaves with an inhibitory concentration (IC 50) of 34.5 µg/mL towards α-glucosidase was investigated by high-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR. This led to identification of six α-glucosidase inhibitors, namely quercetin (16), trans-tiliroside (17), luteolin (19), quercetin-3-methyl ether (20), 3,5-di-O-caffeoylquinic acid n-butyl ester (26) and 4,5-di-O-caffeoylquinic acid n-butyl ester (29). In addition, nineteen other metabolites were identified. The most active compounds were the two regioisomeric di-O-caffeoylquinic acid derivatives 26 and 29, with IC 50 values of 5.93 and 5.20 µM, respectively. This is the first report of the α-glucosidase inhibitory activity of compounds 20, 26, and 29, and the findings support the important role of Eremanthus species as novel sources of new drugs and/or herbal remedies for treatment of type 2 diabetes.

show abstract

Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-γ Activation in Rats

Cited by 32 publications

References 31 publications

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

High-Resolution α-Glucosidase Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of Antidiabetic Compounds in Eremanthus crotonoides (Asteraceae)

High-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-diabetic compounds in Eremanthus crotonoides (Asteraceae)

Contact Info

Product

Resources

About