Effects of<i>Momordica charantia</i>L. on the Blood Rheological Properties in Diabetic Patients

França, Eduardo Luzía; Ribeiro, Elton Brito; Scherer, Edson Fredulin; Cantarini, D.; Pessoa, Rafael Souza; França, Fernando Luzia; Honório-França, Adenilda Cristina

doi:10.1155/2014/840379

Cited by 33 publications

(44 citation statements)

References 41 publications

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“…The study showed that regular consumption of these tablets associated with positive effects in glucose, cholesterol, HDL, LDL, triglyceride levels and had beneficial effects on glucose tolerance [55]. Furthermore, nanoparticles of extract of M. charantia and its adsorption on polyethylene glycol (PEG) microspheres are considered as an alternative treatment of diabetes [56]. Considering all these facts, it can be concluded that Momordica has potential anti-diabetic properties, which may suggest the inclusion of this plant in anti-diabetic regimens.…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Nagarani

Abirami

Siddhuraju

2014

Food Science and Human Wellness

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Plants with potential therapeutic values have been used from time immemorial to cure various ailments and infectious diseases. Of late, scientific evidences have been provided on the potential therapeutic agent exhibited by certain traditionally used vegetable extracts. The importance of wild edible plants may be traced to antiquity but systemic studies are recent. All the Momordica species have been consumed as vegetable and traditionally used for various disorders. The whole plant parts are ascribed to possess the anti-diabetic effect in traditional medicinal system. The active constituents of Momordica plant parts were cucurbitane type triterpenoids, phenolics, glycosides, and several kinds of peptides including Momordica anti-HIV protein (MAP 30). Recent reports revealed the presence of several kinds of cucurbitane type triterpenoids in leaf, stem and fruits of Momordica species having several pharmacological activities. There is lack of scientific information available on the wild species which also having several bioactive components with potential activities. So the present review compares and highlights the current knowledge of the nutritional value, phytochemistry and physiological effects of wild species with known variety.

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Section: Anti-diabetic Activitymentioning

confidence: 99%

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Nagarani

Abirami

Siddhuraju

2014

Food Science and Human Wellness

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“…As for instance, liquid and translucent emulsions with long-term stability and appropriate for different applications generally exhibit Newtonian behavior with constant viscosity for a wide range of shear rate (Rojas et al, 2009;Acharya and Hartley 2012;Ribeiro et al, 2015;Cotrim et al, 2016). According to the literature, viscosity is largely influenced by modified-release systems associated with change of temperature França et al, 2014). In this report, the prepared formulations of Brazil nut oil and LMS presented Newtonian profile and no change in the hysteresis area.…”

Section: Resultsmentioning

confidence: 58%

Development of Brazil nut oil microemulsion as vehicle for Levamisole

2017

J App Pharm Sci

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Brazil nut (Bertholletia excelsa H. B. K.) is one of the most valuable national Lecythidaceae from Brazil, collaborating with local economy. Besides being rich in nutrients, it has high content of unsaturated fatty acids, proteins and vitamins. On the other hand, levamisole (LMS) is a synthetic imidazothiazole derivative mostly used as agent in anthelmintic treatment; however it is reported to have issues in its oral bioavailability. Microemulsion (ME), immiscible liquids stabilized by surfactants, is a promising bioavailability enhancer nowadays by modifying the release of active ingredient at its site of action, reducing therapeutic dosage with consequent side effects, and increasing absorption of natural ingredients. So, the development of a stable ME containing Brazil nut oil to carry LMS can be a promising pharmaceutical form in this drug therapeutic efficiency behalf. For that, it was developed a stable oil-in-water ME which held pH, conductivity, and refractive index along the study, presenting satisfactory stability under long-term stress conditions. Its particle size is classified as nanostructure (33,35nm), and rheological parameters confirmed a Newtonian behavior, with constant viscosity. The Brazil nut oil ME can be an alternative as adjuvant in pharmaceutical forms and a promising upgrading tool to carry LMS, improving its therapy.

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“…Several candidate functional materials have been evaluated by assessing the biocompatibility and interaction with human cells. 14,26 The data suggest that the acid and cement treatments applied to the metal surfaces resulted in a material with low cellular toxicity, which can be used to improve the application of cemented implant prostheses.…”

Section: Discussionmentioning

confidence: 99%

“…The rheological parameters were measured using a Modular Compact Rheometer -MCR 102 (Anton Paar ® Germany GmbH, Ostfildern, Germany) according to França et al 14 In all of the experiments, the implant surfaces treated or untreated with phosphoric acid were placed in 600 µL human blood and put on the reading plate surface, and the excess sample was removed. Readings were taken with continuous control of the gap measurement with the supported TruGap™ of 0.099 mm.…”

Section: Rheological Characterization Of the Implant Surfacesmentioning

confidence: 99%

Dental implant surfaces treated with phosphoric acid can modulate cytokine production by blood MN cells

et al. 2019

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The study characterizes dental implant surfaces treated with phosphoric acid to assess the effects of acid treatment on blood cells and correlate them with cytokine levels. The implant surfaces examined were divided into untreated metal surface (US; n = 50), metal surface treated with phosphoric acid (ATS; n = 50) and cement surface (CS; n = 50) groups. The samples were characterized by scanning electron microscopy (SEM) and rheometry. The implants were incubated with human blood mononuclear cells for 24 h, with surface rinsing in the ATS treatment. Cell viability was determined by colorimetric methods and cytokines in the culture supernatant were quantified using flow cytometry. In the ATS group, the surface porosity and contact surface were increased and plaques were observed on the surface. The blood flow and viscosity curves were similar among the treatments, and the high cell viability rates indicate the biocompatibility of the materials used. An increase in the levels of IL-2, IL-4, IL-6, IL-10 and TNF-α was observed in the ATS and CS groups. There were positive correlations between IL-10 and IL-2 levels and between IL-10 and IL-4 levels in the culture supernatant of the ATS group. The results suggest that implant surface treatment with phosphoric acid activates the production of inflammatory cytokines. The increased cytokine levels can modulate the immune response, thereby improving biofunctional processes and promoting the success of dental implants.

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Effects ofMomordica charantiaL. on the Blood Rheological Properties in Diabetic Patients

Cited by 33 publications

References 41 publications

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Development of Brazil nut oil microemulsion as vehicle for Levamisole

Dental implant surfaces treated with phosphoric acid can modulate cytokine production by blood MN cells

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