Effects of <i>Rhus coriaria L.</i> hydroalcoholic extract on the lipid and antioxidant profile in high fat diet-induced hepatic steatosis in rats

Pasavei, Abdolmomen Ghaeni; Mohebbati, Reza; Jalili‐Nik, Mohammad; Mollazadeh, Hamid; Ghorbani, Ahmad; Tirkani, Abolfazl Nosrati; Jamshidi, Shirin Taraz; Hashemy, Seyed Isaac; Miri, Hamid Heidarian; Soukhtanloo, Mohammad

doi:10.1080/01480545.2018.1533024

Cited by 15 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, lipid and liver parameters were significantly decreased in morin treated diabetic rats compared to the untreated diabetic rat model that designated its protective activity against STZ induced effects. Reported literature [ 13 , 48 ] by other researchers also confirmed the antioxidant, hypoglycemic, hypolipidemic, and reduced lipid peroxidative effects using plant extracts in the STZ-induced diabetic rat.…”

Section: Discussionmentioning

confidence: 64%

Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

et al. 2021

View full text Add to dashboard Cite

The increase in resistance of microbes against conventional drugs is currently a hot issue, whereas diabetes is another main cause of mortalities encountered throughout the world after cancer and heart attacks. New drug sources in the form of plants are investigated to get effective drugs for the mentioned diseases with minimum side effects. Elaeagnus umbellata Thunb. is a medicinal plant used for the management of stress related disorders like diabetes and other health complications. The active constituents of the chloroform extract derived from E. umbellata berries was isolated by silica gel column chromatography which were identified as morin, phloroglucinol, and 1-hexyl benzene through various spectroscopic techniques (electron ionization mass spectrometry, 1H-NMR, and 13C-NMR spectroscopy). The possible protective effects (antioxidant, antibacterial, and antidiabetic activity) of isolated compounds were evaluated using reported methods. Morin exhibited strong in vitro antiradical potential against DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) radicals along with prominent antibacterial activities against selected bacterial strains (Escherichia coli, Bacillus cereus, Salmonella typhi, Klebsiella pneumonia, Pseudomonas aeruginosa and Proteus mirabilis). Among the isolated compounds the more potent one (morin) was assessed for its in vivo antidiabetic potential in streptozotocin-induced diabetic rat model. The in vivo effects observed were further confirmed in ex vivo experiments where the effect of isolated compound on antioxidant enzyme like glutathione peroxidase (GPx), total content of reduced glutathione (GSH), % DPPH inhibition, and the lipid peroxidation MDA (Malondialdehyde) level in pancreatic tissues homogenates were evaluated. In vivo morin at tested doses (2, 10, 15, 30 and 50 mg/kg body weight) significantly restored the alterations in the levels of fasting blood glucose level and body weight loss along with significant decrease in levels of cholesterol, triglycerides, low density lipoprotein, HbA1c level, and significantly increased the high-density lipoprotein in diabetic rats. Morin also effectively ameliorated the hepatic enzymes, and renal functions like serum creatinine. Morin significantly increased the antioxidant enzyme like GPx activity, GSH content, and % DPPH inhibition activity, while reduced the lipid peroxidation MDA (malondialdehyde) level in pancreatic tissues homogenates, and modification of histopathological changes in diabetic rats. Morin exhibited high antioxidant, antibacterial, and antidiabetic potentials as compared to phloroglucinol and 1-hexyl benzene, that could, therefore, be considered as a promising therapeutic agent to treat diabetes mellitus and bacterial infections.

show abstract

Section: Discussionmentioning

confidence: 64%

Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In rodent models of diabetes and dyslipidemia, dietary sumac powder and oral dosing with aqueous and alcoholic extracts were assessed 24–35 . In general, some improvements in measures of blood glucose homeostasis and lipid profiles were observed.…”

Section: Effects Of R Coriaria In Humansmentioning

confidence: 99%

“…In rodent models of diabetes and dyslipidemia, dietary sumac powder and oral dosing with aqueous and alcoholic extracts were assessed. [24][25][26][27][28][29][30][31][32][33][34][35] In general, some improvements in measures of blood glucose homeostasis and lipid profiles were observed. Potential mechanisms were essentially limited to enhanced antioxidant defenses, inhibition of α-glucosidase, maltase and sucrase activities, and suppression of production of proinflammatory mediators.…”

Section: Effects Of R Coriaria In Humansmentioning

confidence: 99%

Sumac

Singletary¹

2023

Nutr Today

View full text Add to dashboard Cite

The spice sumac is prepared from the fruit of the small deciduous tree Rhus coriaria L. (family Anacardiaceae), cultivated mainly in the Mediterranean region, North Africa, and the Middle East. The genus Rhus contains well over a hundred individual species of flowering plants, some varieties of which are edible, including not only R. coriaria but also R. glabra L. (or smooth sumac) used by the indigenous peoples of North America, Rhus typhina L. (staghorn sumac), and R. aromatica Aiton (fragrant sumac), among others. In the Middle East and Turkey, sumac is commonly included in food preparations to impart a tangy, citruslike flavor. Primarily in the Middle East, sumac is used extensively in traditional medicine. Sumac extracts may be used to treat diarrhea, diseases of the mouth and throat, gastrointestinal distress, inflammatory conditions of the skin, and pain, to name a few. Recent human studies examining the potential health benefits of sumac are limited and mainly explore the actions of R. coriaria toward cardiometabolic risk factors. This narrative overview summarizes these clinical trials, as well as relevant, associated animal experiments, and suggests opportunities for future research. Nutr Today 2023;58:77-83 T he spice sumac is prepared from the fruit of the shrub or small deciduous tree R. coriaria L. (family Anacardiaceae) that grows mainly in the Mediterranean region, North Africa, and the Middle East. The word sumac is derived from the Arabic word sumaq, which means red or dark red, a term that aptly describes the col-ored fruit of this flowering plant (Figure 1). R. coriaria is also known as Sicilian sumac and tanner's sumac due to the use of its tannin-rich leaves and bark in leather tanneries. 1,2 Moreover, black and yellow dyes are prepared from these leaves and bark. A relative of this plant, Rhus vernix or Toxicodendron vernix Kuntze (R. vernix L.) also called poison sumac, is not edible and is well known to produce an allergic skin reaction upon contact. However, the genus Rhus contains well over a hundred individual species of flowering plants, some varieties of which are edible. Besides R. coriaria, other examples are R. glabra L. (or smooth sumac) used by the indigenous people of North America, R. typhina L. (staghorn sumac), R. integrifolia (Nutt.) Benth. & Hock. f. ex. Rothr (lemonade berry), R. aromatica Aiton (fragrant sumac), R. ovata S. Watson (sugar bush), and R. trilobata Nutt. (skunkbush sumac, sourberry, three-leaf sumac, squawbush). [3][4][5] In the Middle East and Turkey, sumac is widely added to diverse food preparations. The fruits of this plant are composed of compact clusters of red berries that are dried and ground to yield the dark red/purple spice, the taste of which has been described as tangy, astringent, and lemony. The Arabic spice blend Za'atar has sesame seeds, thyme, and sumac as core ingredients, with other possible components such as oregano, marjoram, coriander, and cumin as additions. In Turkish piyaz salad, the sumac fruit is ground with salt, mixed with oliv...

show abstract

“…The desirable effect of sumac supplementation on metabolic markers has been investigated by both experimental investigations on animals and randomized clinical trials (RCTs) on human subjects (Ahangarpour et al, 2017; Asgary et al, 2018; Doğan & Çelik, 2016; Ghaeni Pasavei et al, 2021; Ghafouri et al, 2021; Hariri et al, 2020; Rahideh et al, 2014; Shidfar et al, 2014). Previous evidence illustrated that sumac supplementation had a favorable effect on lipid profile, in patients with mild to moderate hyperlipidemia (Asgary et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The effect of sumac supplementation on insulin resistance, inflammation, oxidative stress, and antioxidant capacity in adults with metabolic syndrome: A randomized crossover clinical trial

Hajhashemy

Mirenayat

Siavash

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

The impact of sumac supplementation was not previously examined in patients with metabolic syndrome (MetS). So, we investigated the influence of sumac supplementation on insulin resistance, inflammation, oxidative stress, and antioxidant markers in adults with MetS. The current study was a single-center, triple-blind, randomized, placebo-controlled crossover clinical trial that was conducted on 47 patients with MetS. Participants were randomly divided into two groups of intervention and control in the first phase. They received capsules containing 500 mg sumac or placebo (lactose) twice a day, after lunch and dinner, for 6 weeks. After a 2-week washout period, the subjects crossed over to the alternate arm. In both arms, fasting venous blood samples were obtained at baseline and at the sixth week of the intervention to determine glycemic status, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), total antioxidant capacity (TAC), and antioxidant enzymes activity. The mean (±SD) age, weight, and body mass index of participants were respectively 58.7 ± 5.83 years, 79.9 ± 14.35 kg, and 31.6 ± 4.6 kg/m 2 ; 80.9% of subjects were females (n = 38). Based on per-protocol analyses, the serum fasting insulin concentration was unexpectedly decreased in the placebo group (change in sumac vs. control: 0.95 ± 3.9 vs. À1.17 ± 3.9 mU/L; p = 0.04). Sumac supplementation, compared to control, has marginally enhanced catalase activity (change in sumac vs. control: 2.91 ± 9.5 vs. À1.07 ± 9.1 nmol/min/ml; p = 0.06). This supplementation has also increased serum TAC and the activity of superoxide dismutase, but these changes were not significant. This intervention did not affect other insulin resistance, inflammatory, or oxidative stress markers. We found that 1 g/day sumac consumption for 6 weeks, as

show abstract

Effects of Rhus coriaria L. hydroalcoholic extract on the lipid and antioxidant profile in high fat diet-induced hepatic steatosis in rats

Cited by 15 publications

References 48 publications

Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

Sumac

The effect of sumac supplementation on insulin resistance, inflammation, oxidative stress, and antioxidant capacity in adults with metabolic syndrome: A randomized crossover clinical trial

Contact Info

Product

Resources

About